Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8.

abstract：:Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities. Furthermore, interactions between PTH and gp130 signaling have suggested that gp130 signaling might influence calcium homeostasis. We, therefore, examined th...

journal_title：Endocrinology

authors： Shin HI,Divieti P,Sims NA,Kobayashi T,Miao D,Karaplis AC,Baron R,Bringhurst R,Kronenberg HM

更新日期：2004-03-01 00:00:00

abstract：:The present experiments were devoted to analyzing the hypothesis that somatostatin (SS) could modulate glomerular filtration rate by interacting with mesangial cells. Studies were performed in cultured human mesangial cells, passages 3-5. Radioligand experiments demonstrated the presence in the cells of two kinds of r...

journal_title：Endocrinology

authors： Díez-Marqués ML,García-Escribano C,Medina J,Boyano-Adanez MC,Arilla E,Torrecilla G,Rodríguez-Puyol D,Rodríguez-Puyol M

更新日期：1995-08-01 00:00:00

abstract：:Studies on hormone-receptor interactions generally assume that the formation of a hormone-receptor complex is a reversible process. This assumption has been examined directly in three experiments using liver membrane receptor preparations from pregnant rats and ovine PRL (oPRL). In Exp 1, Receptors were preincubated w...

journal_title：Endocrinology

authors： van der Gugten AA,Waters MJ,Murthy GS,Friesen HG

更新日期：1980-01-01 00:00:00

abstract：:Treatment of inflammation is often accomplished through the use of glucocorticoids. However, their use is limited by side effects. We have examined the activity of a novel glucocorticoid receptor ligand that binds the receptor efficiently and strongly represses inflammatory gene expression. This compound has potent an...

journal_title：Endocrinology

authors： López FJ,Ardecky RJ,Bebo B,Benbatoul K,De Grandpre L,Liu S,Leibowitz MD,Marschke K,Rosen J,Rungta D,Viveros HO,Yen WC,Zhi L,Negro-Vilar A,Miner JN

更新日期：2008-05-01 00:00:00

abstract：:The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate...

journal_title：Endocrinology

authors： Liu Y,Yan C,Wang Y,Nakagawa Y,Nerio N,Anghel A,Lutfy K,Friedman TC

更新日期：2006-11-01 00:00:00

abstract：:Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...

journal_title：Endocrinology

authors： Castroneves LA,Jugo RH,Maynard MA,Lee JS,Wassner AJ,Dorfman D,Bronson RT,Ukomadu C,Agoston AT,Ding L,Luongo C,Guo C,Song H,Demchev V,Lee NY,Feldman HA,Vella KR,Peake RW,Hartigan C,Kellogg MD,Desai A,Salvatore D

更新日期：2014-10-01 00:00:00

abstract：:In muscle, physiologic hyperinsulinemia, presumably acting on endothelial cells (ECs), dilates arterioles and regulates both total blood flow and capillary recruitment, which in turn influences glucose disposal. In cultured ECs, however, supraphysiological (e.g. >or=10 nM) insulin concentrations are typically used to ...

journal_title：Endocrinology

authors： Li G,Barrett EJ,Wang H,Chai W,Liu Z

更新日期：2005-11-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00

abstract：:FSH has been shown to stimulate the uptake of calcium in cultured rat Sertoli cells, resulting in an increase in cytosolic calcium concentrations. One possibility which has been put forth is that the FSH receptor per se may act as a calcium channel. This is all the more tantalizing given the proposed structure of this...

journal_title：Endocrinology

authors： Shibata EF,Matsuda JJ,Volk KA,Collison KA,Segaloff DL

更新日期：1992-08-01 00:00:00

abstract：:The effects of retinoic acids (RAs) on development of seminal vesicles (SVs) of neonatal mice were investigated in vitro. SVs from 0-day-old male mice were cultured for 2-6 days in serum-free, chemically defined medium containing transferrin and BSA supplemented with 5alpha-dihydrotestosterone (DHT; 10(-8) M) and insu...

journal_title：Endocrinology

authors： Tanji N,Yokoyama M,Takeuchi M,Terada N,Dahiya R,Cunha GR

更新日期：1996-07-01 00:00:00

abstract：:[125I]-[D-Ser(TBU)6]LHRH-EA binds to a single class of high affinity sites in rat anterior pituitary cells in culture at an apparent dissociation constant of 0.25 nM at 0-4C. The order of potency of a representative group of LHRH agonists and antagonists to displace the labeled ligand is similar to their LH-releasing ...

journal_title：Endocrinology

authors： Giguere V,Lefebvre FA,Labrie F

更新日期：1981-01-01 00:00:00

abstract：:The enzyme glutamate decarboxylase-65 (GAD65) is a major autoantigen in autoimmune diabetes. The mechanism whereby autoreactivity to GAD65, an intracellular protein, is triggered is unknown, and it is possible that immunoreactive GAD65 is released by injured pancreatic islet beta-cells. There is a great need for metho...

journal_title：Endocrinology

authors： Waldrop MA,Suckow AT,Marcovina SM,Chessler SD

更新日期：2007-10-01 00:00:00

abstract：:Progesterone has the capacity to suppress hypothalamic dopaminergic neuronal activity on proestrous afternoon and prolong or amplify the preovulatory prolactin surge in rats. In the present study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling...

journal_title：Endocrinology

authors： Liu B,Arbogast LA

更新日期：2008-04-01 00:00:00

abstract：:The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low le...

journal_title：Endocrinology

authors： Kogai T,Hershman JM,Motomura K,Endo T,Onaya T,Brent GA

更新日期：2001-08-01 00:00:00

abstract：:The GnRH neurosecretory system undergoes marked structural and functional changes throughout life. The initial goal of this study was to examine the neuroanatomical relationship between GnRH neurons and a glycoprotein implicated in neuroplasticity, the polysialylated form of neural cell adhesion molecule (PSA-NCAM). U...

journal_title：Endocrinology

authors： Viguié C,Jansen HT,Glass JD,Watanabe M,Billings HJ,Coolen L,Lehman MN,Karsch FJ

更新日期：2001-03-01 00:00:00

abstract：:Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh ...

journal_title：Endocrinology

authors： Kassis JA,Walent JH,Gorski J

更新日期：1984-08-01 00:00:00

abstract：:The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well understood. To help define the role of this isoform in bone, we developed a transgenic mouse in which targeted expression of human mCSF-1 in osteoblasts was achieved under the control of t...

journal_title：Endocrinology

authors： Yao GQ,Wu JJ,Sun BH,Troiano N,Mitnick MA,Insogna K

更新日期：2003-08-01 00:00:00

abstract：:Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues. In addition to the binding of these hormones to their receptors, formation and metabolism are important in the action of steroids. Metabolism of the potent steroid hormones includes glucuroni...

journal_title：Endocrinology

authors： Turgeon D,Carrier JS,Lévesque E,Hum DW,Bélanger A

更新日期：2001-02-01 00:00:00

abstract：:The human estrogen receptor alpha (ERalpha) and the recently identified ERbeta share a high degree of amino acid homology; however, there are significant differences in regions of these receptors that would be expected to influence transcriptional activity. Consequently, we compared the mechanism(s) by which these rec...

journal_title：Endocrinology

authors： Hall JM,McDonnell DP

更新日期：1999-12-01 00:00:00

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:Fibrosis (extracellular matrix accumulation) is the final end point in diabetic cardiomyopathy. The current study evaluated the therapeutic effects of the antifibrotic hormone relaxin (RLX) in streptozotocin-treated transgenic mRen-2 rats, which undergo pathological and functional features similar to human diabetes. T...

journal_title：Endocrinology

authors： Samuel CS,Hewitson TD,Zhang Y,Kelly DJ

更新日期：2008-07-01 00:00:00

abstract：:Recent evidence has suggested that a circadian rhythm exists for plasma beta-endorphin-like immunoreactivity. The purpose of the present study was to examine the long term effects of surgical trauma on plasma beta-endorphin dynamics. Blood samples for RIA were obtained from female baboons every 4 h for three 48-h peri...

journal_title：Endocrinology

authors： McIntosh TK

更新日期：1987-05-01 00:00:00

abstract：:To address the role of the GH-binding protein (GHBP) in GH physiology, two forms of recombinant human GHBP (rhGHBP) were given alone or in combination with rhGH to hypophysectomized rats or GH-deficient dwarf rats. Hypophysectomized rats were given daily sc injections of excipient, hGH, rhGHBP, or rhGH plus rhGHBP (pr...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Spencer SA,McKay P,Mulkerrin M,Moore J,Cunningham BC

更新日期：1996-10-01 00:00:00

abstract：:GH has physiological functions in many tissues, but the cellular targets for direct effects of GH remain ill defined in complex tissues such as the growth plate in which the contribution of direct vs. indirect actions of GH remains controversial. The Janus kinase (Jak)-signal transducer and activator of transcription ...

journal_title：Endocrinology

authors： Gevers EF,Hannah MJ,Waters MJ,Robinson IC

更新日期：2009-08-01 00:00:00

abstract：:The injection of chlorpropamide into Brattleboro homozygous rats (di/di) has previously been shown to result in enhanced activation of renal medullary adenylate cyclase activity and increased renal medullary content of cAMP in response to 1-desamino-8-D-arginine vasopressin (dDAVP). In contrast, in vivo chlorpropamide...

journal_title：Endocrinology

authors： Moses AM,Fenner R,Schroeder ET,Coulson R

更新日期：1982-12-01 00:00:00

abstract：:In mammals, adrenal medulla chromaffin cells constitute a fundamental component of the sympathetic nervous system outflow, producing most of the circulating adrenaline. We recently found that the rhesus monkey adrenal gland expresses several genes in a 24-h rhythmic pattern, including TH (the rate-limiting enzyme in c...

journal_title：Endocrinology

authors： Lemos DR,Goodspeed L,Tonelli L,Antoch MP,Ojeda SR,Urbanski HF

更新日期：2007-12-01 00:00:00

abstract：:The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable therapeutic potential in the treatment of cancer. We previously reported that the 16-kilodalton N-terminal fragment of ra...

journal_title：Endocrinology

authors： Clapp C,Martial JA,Guzman RC,Rentier-Delure F,Weiner RI

更新日期：1993-09-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:The recently discovered estrogen receptor-beta (ERbeta) is expressed in rodent and human testes. To obtain insight in the physiological role of ERbeta we have investigated the cell type-specific expression pattern of ERbeta messenger RNA (mRNA) and protein in the testis of rats of various ages by in situ hybridization...

journal_title：Endocrinology

authors： van Pelt AM,de Rooij DG,van der Burg B,van der Saag PT,Gustafsson JA,Kuiper GG

更新日期：1999-01-01 00:00:00

abstract：:By the use of sucrose density gradient and protamine sulfate analyses, the cytosol fraction of rat lung has been found to contain binding activities for both androgenic and estrogenic steroids. These activities are present in lungs of rats of both sexes and at all ages examined. Both activities interacted stereospecif...

journal_title：Endocrinology

authors： Morishige WK,Uetake CA

更新日期：1978-06-01 00:00:00