Development-related effects of recombinant activin on steroid synthesis in rat granulosa cells.

abstract：:Somatostatin has been demonstrated to negatively regulate pancreatic growth in vivo. In this study we used the AR4-2J rat pancreatic acinar tumor cell line to investigate the effect of a stable somatostatin analog, SMS 201-995 (SMS) on cell proliferation. SMS induced an antiproliferative effect on both serum or epider...

journal_title：Endocrinology

authors： Viguerie N,Tahiri-Jouti N,Ayral AM,Cambillau C,Scemama JL,Bastié MJ,Knuhtsen S,Estève JP,Pradayrol L,Susini C

更新日期：1989-02-01 00:00:00

abstract：:In the present study the effects of stimulus deprivation on vasoactive intestinal peptide (VIP)- and alpha 1-adrenergically mediated amplification of VIP-stimulated cAMP and cGMP accumulation were examined. Dispersed pinealocytes were prepared from either Sprague-Dawley rats maintained for 2 weeks in a normal lighting...

journal_title：Endocrinology

authors： Chik CL,Ho AK

更新日期：1991-02-01 00:00:00

abstract：:We previously examined the segregation patterns of two polymorphic restriction enzyme sites for EcoRI and HindIII in the 3'-flanking region of human CG-alpha gene in placenta and choriocarcinoma. We observed that a unique combination of restriction sites predominates in choriocarcinoma while this pattern was rare in p...

journal_title：Endocrinology

authors： Otani T,Boime I

更新日期：1986-11-01 00:00:00

abstract：:Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...

journal_title：Endocrinology

authors： Lecomte MJ,Bertolus C,Ramanantsoa N,Saurini F,Callebert J,Sénamaud-Beaufort C,Ringot M,Bourgeois T,Matrot B,Collet C,Nardelli J,Mallet J,Vodjdani G,Gallego J,Launay JM,Berrard S

更新日期：2018-04-01 00:00:00

abstract：:We have previously shown that in reaggregate cell cultures of 14-day-old female rat pituitary, LHRH is capable of stimulating lactotrophs to enter the S-phase of the cell cycle, and that this effect is mediated by paracrine growth factors secreted from gonadotrophs. In the present report we describe the isolation, pur...

journal_title：Endocrinology

authors： Tilemans D,Andries M,Proost P,Devreese B,Van Beeumen J,Denef C

更新日期：1994-07-01 00:00:00

abstract：:Using a sensitive method for the simultaneous measurement of TSH subunit mRNAs, we have investigated their hormonal regulation in the pituitary glands of normal and hypothyroid rats. Oligodeoxyribonucleotides (probes) complementary to coding regions of rat alpha- and TSH beta-subunit mRNAs were synthesized. These prob...

journal_title：Endocrinology

authors： Carr FE,Ridgway EC,Chin WW

更新日期：1985-09-01 00:00:00

abstract：:Although many studies have investigated the complex interrelationships between thyroid hormone levels and insulin-glucose secretion and action, there is at present a lack of information concerning the effects of various thyroid hormone levels on insulin receptors. In the present study, rat liver membranes were prepare...

journal_title：Endocrinology

authors： DeRuyter H,Burman KD,Wartofsky L,Taylor SI

更新日期：1982-06-01 00:00:00

abstract：:Cushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamin...

journal_title：Endocrinology

authors： Occhi G,Regazzo D,Albiger NM,Ceccato F,Ferasin S,Scanarini M,Denaro L,Cosma C,Plebani M,Cassarino MF,Mantovani G,Stalla GK,Pecori Giraldi F,Paez-Pareda M,Scaroni C

更新日期：2014-09-01 00:00:00

abstract：:The control of ACTH secretion by opiates seems to involve stimulatory and inhibitory pathways, since opiate agonists and antagonists are capable of releasing ACTH in conscious rats. To elucidate the role of different opiate receptors in the control of ACTH release, rats were treated with receptor-selective opiate agon...

journal_title：Endocrinology

authors： Pfeiffer A,Herz A,Loriaux DL,Pfeiffer DG

更新日期：1985-06-01 00:00:00

abstract：:The hypoxic growth plate cartilage requires hypoxia-inducible factor (HIF)-mediated pathways to maintain chondrocyte survival and differentiation. HIF proteins are tightly regulated by prolyl hydroxylase domain-containing protein 2 (Phd2)-mediated proteosomal degradation. We conditionally disrupted the Phd2 gene in ch...

journal_title：Endocrinology

authors： Cheng S,Xing W,Pourteymoor S,Schulte J,Mohan S

更新日期：2016-01-01 00:00:00

abstract：:The present study examined the effects of FSH and insulin (IN) on 17 beta-estradiol (E2) secretion and granulosa cell proliferation. For these studies, immature rat ovaries were maintained in perifusion culture and continuously exposed to FSH (0-800 ng RP-1 eq/ml) and /or IN (0.2 U/ml). At specific times, the ovaries ...

journal_title：Endocrinology

authors： Peluso JJ,Delidow BC,Lynch J,White BA

更新日期：1991-01-01 00:00:00

abstract：UNLABELLED:The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of action for the anorectic effects produced by peripheral administration of these GLP-1R agonists are not known. Experiments addressed whether food intak...

journal_title：Endocrinology

authors： Kanoski SE,Fortin SM,Arnold M,Grill HJ,Hayes MR

更新日期：2011-08-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:This is an obituary for Gregory Goodwin Pincus whose death in August, 1967, terminated a distinguished career in the biological sciences. His major work was in reproductive biology. This work, in collaboration with Dr. John Rock, led to the development and field testing in Puerto Rico of the 1st OC (oral contracepti...

journal_title：Endocrinology

authors： White A

更新日期：1968-04-01 00:00:00

abstract：:Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...

journal_title：Endocrinology

authors： Wira CR,Roche MA,Rossoll RM

更新日期：2002-08-01 00:00:00

abstract：:The GnRH neurosecretory system undergoes marked structural and functional changes throughout life. The initial goal of this study was to examine the neuroanatomical relationship between GnRH neurons and a glycoprotein implicated in neuroplasticity, the polysialylated form of neural cell adhesion molecule (PSA-NCAM). U...

journal_title：Endocrinology

authors： Viguié C,Jansen HT,Glass JD,Watanabe M,Billings HJ,Coolen L,Lehman MN,Karsch FJ

更新日期：2001-03-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:Gonadotropin (GTH)-inhibitory hormone (GnIH) is a novel hypothalamic neuropeptide that inhibits GTH secretion in mammals and birds by acting on gonadotropes and GnRH neurons within the hypothalamic-pituitary-gonadal axis. GnIH and its orthologs that have an LPXRFamide (X = L or Q) motif at the C terminus (LPXRFamide p...

journal_title：Endocrinology

authors： Osugi T,Daukss D,Gazda K,Ubuka T,Kosugi T,Nozaki M,Sower SA,Tsutsui K

更新日期：2012-05-01 00:00:00

abstract：:To determine the relationship between the concentrations of serum T3 and hepatic nuclear T3 receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results...

journal_title：Endocrinology

authors： Las MS,Surks MI

更新日期：1981-10-01 00:00:00

abstract：:The mammalian suprachiasmatic nucleus is the site of the circadian rhythm generator. The degrees of expression there of several neuropeptides, including vasopressin and vasoactive intestinal polypeptide, follow a diurnal rhythm. The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and m...

journal_title：Endocrinology

authors： Young WS 3rd,Kovács K,Lolait SJ

更新日期：1993-08-01 00:00:00

abstract：:This study was conducted to determine the feasibility of using replication-defective adenovirus vectors to express receptors for LH. Two vectors were constructed, one that directs the expression of wild-type human LH receptor (LHr; AdRSVLHrwt) and another that directs the expression of the constitutively activated D57...

journal_title：Endocrinology

authors： Bebia Z,Somers JP,Liu G,Ihrig L,Shenker A,Zeleznik AJ

更新日期：2001-06-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:The dose-dependent displacement characteristics of a biologically active 20,000 molecular weight human pituitary growth hormone variant (20K) and of human growth hormone (hGH) were compared using hGH liver plasma membrane receptors both from 20-30 day pregnant rabbits and from normal female rats and also using mammary...

journal_title：Endocrinology

authors： Sigel MB,Thorpe NA,Kobrin MS,Lewis UJ,Vanderlaan WP

更新日期：1981-04-01 00:00:00

abstract：:The molecular forms of GnRH in amphibia have not been characterized structurally. An antiserum to mammalian GnRH that shows appreciable cross-reactivity with chicken GnRH-I ([Gln8]GnRH), chicken GnRH-II ([His5,Trp7,Tyr8]GnRH), and salmon GnRH ([Trp7, Leu8]GnRH) was used in a RIA to detect GnRH-related peptides in an e...

journal_title：Endocrinology

authors： Conlon JM,Collin F,Chiang YC,Sower SA,Vaudry H

更新日期：1993-05-01 00:00:00

abstract：:PTH-related protein (PTHrP), the major mediator of hypercalcemia of malignancy, reduces tubular phosphate (Pi) reabsorption through its PTH-like renotropic actions. Another peptide detected in tumoral cells, transforming growth factor-beta (TGF beta), has been shown to considerably suppress the sodium-dependent Pi tra...

journal_title：Endocrinology

authors： Law F,Rizzoli R,Bonjour JP

更新日期：1993-07-01 00:00:00

abstract：:Monoclonal antibodies that bind to the TSH receptor were obtained by an autoantiidiotypic approach in which immunization of BALB/c mice was performed with mixtures of bovine (b) and human (h) TSH. Two of 28 positive wells were selected for cloning and characterization: D2 and 4G11. Their antiidiotypic character was ev...

journal_title：Endocrinology

authors： Hill BL,Erlanger BF

更新日期：1988-06-01 00:00:00

abstract：:The effects of continuous high GH levels on GH signal transduction through the GH receptor (GHR)/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway as well as the desensitization of this pathway by suppressors of cytokine signaling (SOCS) were studied in transgenic mice overexpres...

journal_title：Endocrinology

authors： González L,Miquet JG,Sotelo AI,Bartke A,Turyn D

更新日期：2002-02-01 00:00:00

abstract：:We studied the effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation on serum concentrations and tissue expression of resistin, adiponectin, and adiponectin receptor-1 and -2 (AdipoR1 and AdipoR2) mRNA in normal mice and mice with insulin resistance induced by lipogenic, simple-carbohydrat...

journal_title：Endocrinology

authors： Haluzik MM,Lacinova Z,Dolinkova M,Haluzikova D,Housa D,Horinek A,Vernerova Z,Kumstyrova T,Haluzik M

更新日期：2006-09-01 00:00:00

abstract：:The effects of pineal indole compounds on the response of the neonatal rat anterior pituitary gland to LH-releasing hormone (LHRH) were studied in organ culture. After 24 h of culture under control conditions, pituitary glands from 5-day-old female rats were routinely incubated for an additional 24 h with the test com...

journal_title：Endocrinology

authors： Martin JE,Engel JN,Klein DC

更新日期：1977-03-01 00:00:00

abstract：:Insulin-like growth factor (IGF) I, a polypeptide synthesized by skeletal cells, and its amino terminus truncated derivative desamino-(1-3)-IGF I (des-IGF I) were compared for their effects on bone formation in vitro. Des-IGF I and IGF I were studied for their effects on DNA and collagen synthesis in cultures of intac...

journal_title：Endocrinology

authors： Canalis E,McCarthy TL,Centrella M

更新日期：1991-07-01 00:00:00