Abstract:
:Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant treatment poses additional challenges in athletes, as these individuals usually wish to return to sporting activities without delay. In addition, those athletes who engage in contact sports may have bleeding complications with extended anticoagulation. In this paper, we discuss VTE risk factors in athletes, the impact of exertion on haemostasis, measures which could be adopted to mitigate VTE risks in these highly active individuals and options to deal with bleeding risks from anticoagulation during injury-prone sporting activities.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Swan D,Carter-Brzezinski L,Thachil Jdoi
10.1016/j.blre.2020.100780subject
Has Abstractpub_date
2020-11-15 00:00:00pages
100780eissn
0268-960Xissn
1532-1681pii
S0268-960X(20)30130-2pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract::The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(87)90032-4
更新日期:1987-09-01 00:00:00
abstract::Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of th...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2014.03.001
更新日期:2014-05-01 00:00:00
abstract::Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulop...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2012.06.004
更新日期:2012-09-01 00:00:00
abstract::Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are c...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.03.001
更新日期:2013-05-01 00:00:00
abstract::Each cell in our body contains a set of tens of thousands of genes, out of which a set of several thousands determines the cell's characteristics. The deciphering of the sequence of the human genome combined with the technical feasibility to simultaneously measure the gene expression levels of thousands of genes had r...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2004.11.003
更新日期:2005-07-01 00:00:00
abstract::This relatively rare group of disorders may cause quite marked morbidity and occasionally be life-threatening. As their inheritance is largely known accurate information in one family member has obvious benefits to other family members as well as the patient. The identification of the defect is dependent on an accurat...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(90)90042-q
更新日期:1990-09-01 00:00:00
abstract::Early reports would suggest that closely matched UD BMT is an adequate substitute for MSD BMT in children with relapsed ALL. Protagonists of BMT might suggest that UD BMT be used in the absence of a MSD in all cases of BM relapse of ALL. However, recent improvements in chemoradiotherapy schedules have reduced the bene...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(96)90006-5
更新日期:1996-12-01 00:00:00
abstract::Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(03)00002-x
更新日期:2003-06-01 00:00:00
abstract::The myelodysplastic syndromes (MDS) are characterized by cytopenias and acute myeloid leukemia risk. Most MDS patients eventually require transfusion of red blood cells for anemia, placing them at risk of iron overload (IOL). In beta-thalassemia major, transfusional IOL leads to organ dysfunction and death, however, w...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2010.09.003
更新日期:2011-01-01 00:00:00
abstract::Advances in molecular genetic understanding of disease processes has been extended to a number of phagocytic disorders. Most of these disorders were extensively characterized at the functional and protein level prior to cloning of the relevant genes. Nucleotide sequence data has been essential for establishing the mec...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(89)90004-0
更新日期:1989-06-01 00:00:00
abstract::The clinical relevance of flow cytometry (FC)-based bone marrow involvement (BMI) in B cell non-Hodgkin lymphoma (B-NHL) is not well established. We conducted a systematic review of MEDLINE regarding the use of FC to establish BMI in B-NHL to determine the prevalence of BMI by FC, to understand the interrelation betwe...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100778
更新日期:2020-11-08 00:00:00
abstract::The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under crit...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2000.0136
更新日期:2000-12-01 00:00:00
abstract::Childhood immune thrombocytopenic purpura (ITP) is acute and generally seasonal in nature, suggesting that infectious or environmental agents may trigger the immune response to produce platelet-reactive autoantibodies 4 to 8 weeks following an infection. In general, the patient is well apart from the diffuse bruising ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2001.0177
更新日期:2002-03-01 00:00:00
abstract::The binding of haemopoietic growth factors and cytokines to specific receptors triggers a cascade of intracellular events which results in cell proliferation and differentiation. The knowledge of ligand-receptor-signal pathways is not only important in understanding the pathophysiology of malignant disease but also es...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(91)90036-c
更新日期:1991-09-01 00:00:00
abstract::Immune checkpoint inhibitors (ICI) have yielded mixed but largely underwhelming results in clinical trials in patients with acute myeloid leukemia and myelodysplastic syndromes to date. However, increasing understanding of the immunologic landscape, potential biomarkers for benefits, and mechanisms of resistance, as w...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100709
更新日期:2020-05-23 00:00:00
abstract::Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) represent a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. Biochemical markers include elevated ferritin and triglyce...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2007.05.001
更新日期:2007-09-01 00:00:00
abstract::Notch signaling can regulate both hematopoietic progenitors and alloimmune T cells in the setting of allogeneic bone marrow or hematopoietic cell transplantation (allo-HCT). Ex vivo culture of multipotent blood progenitors with immobilized Delta-like ligands induces supraphysiological Notch signals and can markedly en...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.08.001
更新日期:2013-11-01 00:00:00
abstract::The anaemia of chronic disease (ACD) is a common haematologic syndrome characterized by hypoferraemia with adequate reticuloendothelial iron stores. Frequently, serum ferritin concentration in these patients is elevated. The pathogenesis of ACD involves abnormalities in red cell survival, the erythropoietic response t...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/S0268-960X(03)00066-3
更新日期:2004-12-01 00:00:00
abstract::The term epigenetics defines a heritable alteration in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that foster epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and post-translational histone modifications. Disruption of the balanced epi...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.01.006
更新日期:2006-01-01 00:00:00
abstract::Platelet transfusions are widely used. Prophylactic transfusions are employed in severely thrombocytopenic patients without evidence of bleeding, but no randomized trial data prove the safety or efficacy of this approach. Randomized trials have demonstrated the equivalence of transfusion triggers of 10,000 and 20,000/...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/S0268-960X(03)00057-2
更新日期:2004-09-01 00:00:00
abstract::Myelodysplastic syndromes (MDS) are a set of oligoclonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis that manifest clinically as anemia, neutropenia, and/or thrombocytopenia of variable severity. The result often is transfusion-dependent anemia, an increased risk of infection or he...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.01.004
更新日期:2005-11-01 00:00:00
abstract::Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow mic...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100786
更新日期:2020-12-09 00:00:00
abstract::Transfusion-associated graft-versus-host disease is a rare but usually fatal complication of transfusion of cellular blood components, caused by multiorgan engraftment and proliferation of donor T lymphocytes. The classical features of skin rash, diarrhoea and hepatitis, along with striking bone-marrow failure, are se...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(95)90016-0
更新日期:1995-12-01 00:00:00
abstract::A strong association was found to exist between patterns of lymphoid malignancies and socioeconomic status. B-cell lymphomas and T-acute lymphoblastic leukemia are much more prevalent in developing countries where the chances of acquiring infections especially at a younger age are high. B-cell precursor acute lymphati...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(96)90037-5
更新日期:1996-06-01 00:00:00
abstract::The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2016.02.003
更新日期:2016-07-01 00:00:00
abstract::A moderate reduction of plasma antithrombin activity is an uncommon but clinically important cause of severe thromboembolic disease. In recent years the molecule responsible for the major part of this activity (antithrombin III) has been extensively characterised and the mode of inheritance of familial deficiencies wo...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(88)90013-6
更新日期:1988-12-01 00:00:00
abstract::Red blood cell (RBC) alloimmunization is a serious complication of blood transfusions, challenging selection of compatible units for future transfusions. Genetic characteristics may be associated with the risk of RBC alloimmunization and may therefore serve to identify high-risk patients. The aim of this systematic re...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100794
更新日期:2021-01-05 00:00:00
abstract::In this review, salient molecular, biochemical and functional features of human interleukin 2 (IL-2), its membrane receptor, and its clinical relevance are outlined. We also describe experimental systems, where observed biological or pharmacological effects of IL-2 could be applied to corresponding clinical situations...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(87)90027-0
更新日期:1987-12-01 00:00:00
abstract::Patients with myelodysplastic syndrome (MDS) who have more than 10% blasts in their bone marrow have a very short survival. Treatment has not improved for these patients for the past 10 years and supportive care alone is still the gold standard. Intensive chemotherapy for poor prognosis MDS has been little tried, but ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(92)90017-k
更新日期:1992-12-01 00:00:00
abstract::Laboratory and clinical data relating to the use of 2'-deoxycoformycin in human disease are reviewed. Pentostatin is an inhibitor of adenosine deaminase, an enzyme that is important for purine metabolism, but more than one mechanism may be involved in its cytotoxic action. Early studies with dCF employed large doses a...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(87)90004-x
更新日期:1987-06-01 00:00:00