Abstract：
:Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such as hemiparesis and coma. Therefore, it can present to various specialists including general physicians, obstetricians and neurologists. In recent years, more widespread use of cerebral imaging has led to the diagnosis being made more often. Since thrombosis is the key component, haematologists are consulted in the management of these patients including for identification of a causative factor for CVT. In this regard, the pivotal International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) has shed more light on its epidemiology and management options. This review aims to provide guidance to haematologists when faced with a patient with CVT, based on the currently available evidence.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Thorell SE,Parry-Jones AR,Punter M,Hurford R,Thachil Jdoi
10.1016/j.blre.2014.09.006subject
Has Abstractpub_date
2015-01-01 00:00:00pages
45-50issue
1eissn
0268-960Xissn
1532-1681pii
S0268-960X(14)00075-7journal_volume
29pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract：:Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation. Further advances in understanding thrombocytopenias now...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(88)90004-5
更新日期：1988-03-01 00:00:00
abstract：:The advent of highly active antiretroviral therapy (HAART) and its co-administration with chemotherapy in patients with human immunodeficiency virus (HIV)-related lymphoma has lead to the exploration of potentially curative combination chemotherapy and myeloablative therapy followed by autologous haematopoietic stem c...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(03)00026-2
更新日期：2003-12-01 00:00:00
abstract：:MicroRNAs (miRNAs) have become one of the hottest topics in biology over recent years, but remarkably have only been formally recognized for just over 10 years. These endogenously produced short (19-24 nt) non-coding RNAs have introduced an entirely new paradigm in our understanding of gene control and it is now evide...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.04.002
更新日期：2013-05-01 00:00:00
abstract：:For the majority of patients presenting with early Hodgkin's disease, the chance of death due to their disease is related to prognostic factors, e.g. age, systemic symptoms, ESR bulk, number of sites of disease, histology, haemoglobin, lymphocyte count etc. More than 50% of those with Stage I and IIA disease fall into...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(91)90011-z
更新日期：1991-12-01 00:00:00
abstract：:The transfusion approach to massive hemorrhage has continually evolved since it began in the early 1900s. It started with fresh whole blood and currently consists of virtually exclusive use of component and crystalloid therapy. Recent US military experience has reinvigorated the debate on what the most optimal transfu...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2009.07.003
更新日期：2009-11-01 00:00:00
abstract：:Invasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this comp...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2009.11.003
更新日期：2010-03-01 00:00:00
abstract：:Each cell in our body contains a set of tens of thousands of genes, out of which a set of several thousands determines the cell's characteristics. The deciphering of the sequence of the human genome combined with the technical feasibility to simultaneously measure the gene expression levels of thousands of genes had r...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2004.11.003
更新日期：2005-07-01 00:00:00
abstract：:Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation thrombopoietic agents were recombinant forms of human TPO, and their developme...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2010.04.002
更新日期：2010-07-01 00:00:00
abstract：:This relatively rare group of disorders may cause quite marked morbidity and occasionally be life-threatening. As their inheritance is largely known accurate information in one family member has obvious benefits to other family members as well as the patient. The identification of the defect is dependent on an accurat...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(90)90042-q
更新日期：1990-09-01 00:00:00
abstract：:After many unsuccessful years of searching, the first pathogenic human retrovirus, the human T-cell leukaemia lymphoma virus (HTLV-I), was reported as recently as 1980 and since that time has been causally linked to the adult T-cell leukaemia lymphoma syndrome. A second HTLV (HTLV-II) isolated shortly afterwards is le...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(88)90010-0
更新日期：1988-12-01 00:00:00
abstract：:A strong association was found to exist between patterns of lymphoid malignancies and socioeconomic status. B-cell lymphomas and T-acute lymphoblastic leukemia are much more prevalent in developing countries where the chances of acquiring infections especially at a younger age are high. B-cell precursor acute lymphati...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(96)90037-5
更新日期：1996-06-01 00:00:00
abstract：:Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk during early adulthood. The median lifespan for FA patients is approximately 33years. The proteins encoded by the FA genes function together i...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2016.10.002
更新日期：2017-05-01 00:00:00
abstract：:Methaemoglobinaemia arises from the production of non-functional haemoglobin containing oxidised Fe(3+) which results in reduced oxygen supply to the tissues and manifests as cyanosis in the patient. It can develop by three distinct mechanisms: genetic mutation resulting in the presence of abnormal haemoglobin, a defi...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2004.02.001
更新日期：2005-03-01 00:00:00
abstract：:Recurrent fetal loss and other placental vascular pathologies of pregnancy have long been associated with antiphospholipid syndrome-an acquired autoimmune thrombophilic state. The number of known heritable thrombophilic disorders has grown rapidly in recent years with the identification of activated protein C resistan...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(97)90013-8
更新日期：1997-06-01 00:00:00
abstract：:Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields. This review examines the aetiology of splenomegaly in the developed world, and describes a logical approach to the patient with splenomegaly. In some patients, extensive radiological and laboratory investigations will fa...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2008.10.001
更新日期：2009-05-01 00:00:00
abstract：:The myeloproliferative neoplasms (MPNs) encompass a heterogenous set of diseases that have variable survival, but in the setting of treatment refractory and progressive disease, prognosis has been characteristically poor. JAK inhibition with ruxolitinib or fedratinib therapy has become the first line treatment for sym...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2020.100716
更新日期：2020-07-01 00:00:00
abstract：:Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(03)00002-x
更新日期：2003-06-01 00:00:00
abstract：:Platelet transfusions are widely used. Prophylactic transfusions are employed in severely thrombocytopenic patients without evidence of bleeding, but no randomized trial data prove the safety or efficacy of this approach. Randomized trials have demonstrated the equivalence of transfusion triggers of 10,000 and 20,000/...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/S0268-960X(03)00057-2
更新日期：2004-09-01 00:00:00
abstract：:Drug-induced agranulocytosis is a highly individualized and unexpected reaction to specific drugs. It may be due to immunogenic or cytotoxic factors. Most instances are produced by a poorly understood immune response to immunogenic drugs. Others are associated with direct suppression of marrow committed stem cells by ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(90)90002-a
更新日期：1990-12-01 00:00:00
abstract：:It is the conventional opinion that acquired aplastic anaemia is a heterogenous disease including basically different conditions, such as idiopathic or virus induced pancytopenia, toxic-allergic marrow damage or autoimmunity. Here, an alternative concept is proposed, according to which aplastic anaemia is one disease,...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(90)90032-n
更新日期：1990-06-01 00:00:00
abstract：:Notch signaling can regulate both hematopoietic progenitors and alloimmune T cells in the setting of allogeneic bone marrow or hematopoietic cell transplantation (allo-HCT). Ex vivo culture of multipotent blood progenitors with immobilized Delta-like ligands induces supraphysiological Notch signals and can markedly en...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.08.001
更新日期：2013-11-01 00:00:00
abstract：:Hemophilia A is an X-linked hereditary bleeding disorder due to the deficiency of coagulation factor VIII (FVIII). According to the degree of FVIII deficiency, mild, moderate or severe forms are recognized. Although patients with mild hemophilia A usually bleed excessively only after trauma or surgery, those with seve...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.06.002
更新日期：2013-07-01 00:00:00
abstract：:The term epigenetics defines a heritable alteration in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that foster epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and post-translational histone modifications. Disruption of the balanced epi...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2005.01.006
更新日期：2006-01-01 00:00:00
abstract：:Lymphomas cause significant morbidity and mortality worldwide. A substantial number of patients ultimately relapse after standard treatment. However, the efficacy of these therapies can be counteracted by the patients' immune system, more specifically by myeloid-derived suppressor cells (MDSC). MDSC are a heterogeneou...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2018.04.006
更新日期：2018-11-01 00:00:00
abstract：:A working diagnosis of essential thrombocythemia (ET) is made in the presence of nonreactive thrombocytosis and after the exclusion of another chronic myeloid disorder that may mimic ET in its presentation. Clinically, ET is characterized by vasomotor symptoms, thrombohemorrhagic complications, recurrent fetal loss, a...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2001.0158
更新日期：2001-09-01 00:00:00
abstract：:The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin i...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(93)90002-l
更新日期：1993-09-01 00:00:00
abstract：:The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(87)90032-4
更新日期：1987-09-01 00:00:00
abstract：:In the vicinity of an acute inflammatory response both cellular and non-cellular elements may interact to modify the overall response. Evidence suggests that leukocytes may play an active role in the modulation of platelet function and vice-versa. This interaction may be abnormal in certain pathological states. Neutro...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(92)90010-n
更新日期：1992-06-01 00:00:00
abstract：:Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF would interfere with the polymerization of sickle hemoglobin while in beta-thalassemia, an increase in gamma-globin chain synthesis would decrease...
journal_title：Blood reviews
pub_type： 杂志文章
doi：10.1016/j.blre.2006.01.002
更新日期：2006-07-01 00:00:00
abstract：:Current trends in the treatment of patients with Stages I and II Hodgkin's disease are discussed in this review. Recommendations for staging procedures and the updated staging classification are described. Long-term results with extended field radiation therapy overall and in subgroups of patients are detailed. As fol...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(93)90022-v
更新日期：1993-03-01 00:00:00
