Abstract：
:Immune checkpoint inhibitors (ICI) have yielded mixed but largely underwhelming results in clinical trials in patients with acute myeloid leukemia and myelodysplastic syndromes to date. However, increasing understanding of the immunologic landscape, potential biomarkers for benefits, and mechanisms of resistance, as well as the use of rational combinations, and identification of novel targets leaves plenty of room for optimism. Herein, we review recent advances in the preclinical and clinical development of ICI therapy in patients with myeloid malignancies and explore some of the important challenges facing the field such as the absence of validated biomarkers, the development of synergistic and safe combination therapies, and efforts to determine the best setting of ICI along the disease course. We finally foresee the future of the field and propose solutions to some of the major beforementioned obstacles.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Bewersdorf JP,Shallis RM,Zeidan AMdoi
10.1016/j.blre.2020.100709subject
Has Abstractpub_date
2020-05-23 00:00:00pages
100709eissn
0268-960Xissn
1532-1681pii
S0268-960X(20)30059-Xpub_type
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