Abstract：
:In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and signalling pathways that contribute to thrombus formation and are used as targets in (pre)clinical intervention studies to prevent cardiovascular disease. Discussed are receptors for thrombin, thromboxane, ADP, ATP, prostaglandins, von Willebrand factor, collagen, CLEC-2 ligand, fibrinogen and laminin. Sketched are the consequences of receptor deficiency or blockage for haemostasis and thrombosis in mouse and man. Recording of bleeding due to (congenital) platelet dysfunction or (acquired) antiplatelet treatment occurs according to different protocols, while common laboratory methods are used to determine platelet function.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Swieringa F,Kuijpers MJ,Heemskerk JW,van der Meijden PEdoi
10.1016/j.blre.2013.12.001subject
Has Abstractpub_date
2014-01-01 00:00:00pages
9-21issue
1eissn
0268-960Xissn
1532-1681pii
S0268-960X(13)00083-0journal_volume
28pub_type
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