Abstract：
:Stimulation with the vasopressin analogue desmopressin (DDAVP) of extrarenal arginine vasopressin (AVP) V2-receptors in endothelial cells and possible in platelets increases the circulating levels of coagulation factor VIII (FVIII), von Willebrand factor (VWF) and tissue plasminogen activator (t-PA). The purpose of this paper is to provide an updated review of current information on the efficacy and safety of DDAVP in the treatment of haemophilia, von Willebrand disease (VWD), uremia, liver cirrhosis, and in congenital or drug-induced platelet dysfunction--under surgical or non-surgical conditions. In summary, desmopressin is an effective haemostatic drug that when administered i.v., s.c. or intranasally increases plasma levels of FVIII and VWF 2-6 times and improves platelet function. It has a proven haemostatic efficacy in mild haemophilia A and VWD as well as in uremia, liver cirrhosis and in congenital and acquired, drug induced platelet dysfunction. Desmopressin has few side effects but observation is advised in small children and elderly.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Svensson PJ,Bergqvist PB,Juul KV,Berntorp Edoi
10.1016/j.blre.2014.03.001subject
Has Abstractpub_date
2014-05-01 00:00:00pages
95-102issue
3eissn
0268-960Xissn
1532-1681pii
S0268-960X(14)00027-7journal_volume
28pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract：:Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), for...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2019.04.003
更新日期：2019-07-01 00:00:00
abstract：:Erythropoiesis is a dynamic process regulated at multiple levels to balance proliferation, differentiation and survival of erythroid progenitors. Ineffective erythropoiesis is a key feature of various diseases, including β-thalassemia. The pathogenic mechanisms leading to ineffective erythropoiesis are complex and sti...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2017.10.001
更新日期：2018-03-01 00:00:00
abstract：:Inherited hemoglobin-related disorders, which include the structural variants (hemoglobin S, C, and E) and the alpha (α)- and beta (β)-thalassemias, affect more than 300,000 children annually, particularly in malaria-endemic regions stretching from sub-Saharan Africa and the Mediterranean to Southeast Asia. Screening ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/S0268-960X(12)70003-6
更新日期：2012-04-01 00:00:00
abstract：:Each cell in our body contains a set of tens of thousands of genes, out of which a set of several thousands determines the cell's characteristics. The deciphering of the sequence of the human genome combined with the technical feasibility to simultaneously measure the gene expression levels of thousands of genes had r...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2004.11.003
更新日期：2005-07-01 00:00:00
abstract：:T cells are implicated in the effective control of chronic myeloid leukemia (CML). Recently, several clinical observations supported by laboratory data, indicate the presence of CML-specific T cells. Many proteins potentially act as leukemia-specific antigens for MHC-restricted cytotoxicity in CML. These include the b...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2000.0127
更新日期：2000-06-01 00:00:00
abstract：:This review sets out to synthesize and critically evaluate the current reported data regarding therapeutic options for the neutropenia associated with Felty syndrome (Felty neutropenia). A MEDLINE search and bibliographies from recent reviews were used to identify trials and case reports that provided sufficient data ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(96)90024-7
更新日期：1996-09-01 00:00:00
abstract：:B19 virus is the first human virus to be shown to be a member of the parvovirus genus. This review is concerned with the diseases associated with B19 virus, their nature, pathogenesis and diagnosis. The virus was discovered by chance in blood donors but has been shown to be a common infection of childhood. Infection m...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(87)90020-8
更新日期：1987-03-01 00:00:00
abstract：:Immune checkpoint inhibitors (ICI) have yielded mixed but largely underwhelming results in clinical trials in patients with acute myeloid leukemia and myelodysplastic syndromes to date. However, increasing understanding of the immunologic landscape, potential biomarkers for benefits, and mechanisms of resistance, as w...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2020.100709
更新日期：2020-05-23 00:00:00
abstract：:Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk during early adulthood. The median lifespan for FA patients is approximately 33years. The proteins encoded by the FA genes function together i...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2016.10.002
更新日期：2017-05-01 00:00:00
abstract：:Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF would interfere with the polymerization of sickle hemoglobin while in beta-thalassemia, an increase in gamma-globin chain synthesis would decrease...
journal_title：Blood reviews
pub_type： 杂志文章
doi：10.1016/j.blre.2006.01.002
更新日期：2006-07-01 00:00:00
abstract：:Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation. Further advances in understanding thrombocytopenias now...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(88)90004-5
更新日期：1988-03-01 00:00:00
abstract：:Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2017.04.001
更新日期：2017-09-01 00:00:00
abstract：:The transfusion approach to massive hemorrhage has continually evolved since it began in the early 1900s. It started with fresh whole blood and currently consists of virtually exclusive use of component and crystalloid therapy. Recent US military experience has reinvigorated the debate on what the most optimal transfu...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2009.07.003
更新日期：2009-11-01 00:00:00
abstract：:Four decades ago, two staging systems were developed to help stratify CLL into different prognostic categories. These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia. Better understanding of biologic, genetic, and molecular characteristics...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2017.10.003
更新日期：2018-03-01 00:00:00
abstract：:Extramedullary disease of multiple myeloma (EM) remains a treatment challenge even in the era of new drugs. While many reports analyzing various aspects of EM have been published, mechanism of EM development has not been clarified yet. This review summarizes current knowledge about this clinical entity, including its ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2019.04.002
更新日期：2019-07-01 00:00:00
abstract：:The term epigenetics defines a heritable alteration in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that foster epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and post-translational histone modifications. Disruption of the balanced epi...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2005.01.006
更新日期：2006-01-01 00:00:00
abstract：:Chronic lymphocytic leukemia (CLL) is a disease of older patients and median age at diagnosis is 72 years. This older group is under-represented in clinical trials, (median age 58-62 years). Here we review background data on incidence, survival, definitions of older age, fitness criteria, frailty and co-morbidities. I...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2011.09.002
更新日期：2012-01-01 00:00:00
abstract：:Transfusion-associated graft-versus-host disease is a rare but usually fatal complication of transfusion of cellular blood components, caused by multiorgan engraftment and proliferation of donor T lymphocytes. The classical features of skin rash, diarrhoea and hepatitis, along with striking bone-marrow failure, are se...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(95)90016-0
更新日期：1995-12-01 00:00:00
abstract：:Fears about the risks of disease transmission through the transfusion of homologous blood, as well as problems with blood supply and cost have increased the interest in reducing perioperative bleeding. This article discusses the causes of non-surgical perioperative bleeding and attempts to reduce perioperative bleedin...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(91)90034-a
更新日期：1991-09-01 00:00:00
abstract：:Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2005.06.001
更新日期：2006-01-01 00:00:00
abstract：:It is the conventional opinion that acquired aplastic anaemia is a heterogenous disease including basically different conditions, such as idiopathic or virus induced pancytopenia, toxic-allergic marrow damage or autoimmunity. Here, an alternative concept is proposed, according to which aplastic anaemia is one disease,...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(90)90032-n
更新日期：1990-06-01 00:00:00
abstract：:The clinical relevance of flow cytometry (FC)-based bone marrow involvement (BMI) in B cell non-Hodgkin lymphoma (B-NHL) is not well established. We conducted a systematic review of MEDLINE regarding the use of FC to establish BMI in B-NHL to determine the prevalence of BMI by FC, to understand the interrelation betwe...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2020.100778
更新日期：2020-11-08 00:00:00
abstract：:Advances in therapy can essentially be measured using two parameters; introduction of a new agent which benefits an increased number of patients over prevailing treatments or more selective use of an existing drug by matching it to the biologic characteristics associated with response. In reviewing the therapeutic lan...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2011.11.001
更新日期：2012-03-01 00:00:00
abstract：:Allogeneic stem cell transplantation (alloSCT) is the treatment of choice in the majority of young patients with advanced stages MDS if they have a suitable donor. Since outcome of transplantation is superior for patients with a low blast percentage, this supports the use of chemotherapy prior to transplantation in pa...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2006.03.002
更新日期：2007-01-01 00:00:00
abstract：:The process of megakaryocytopoiesis begins with the commitment of a pluripotent hematopoietic stem cell to a differentiation pathway that culminates in the release of mature platelets into the circulation. A variety of megakaryocyte precursor cells have been identified after stem cell commitment has occurred and these...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(95)90034-9
更新日期：1995-03-01 00:00:00
abstract：:Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulop...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2012.06.004
更新日期：2012-09-01 00:00:00
abstract：:In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and sign...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.12.001
更新日期：2014-01-01 00:00:00
abstract：:For the majority of patients presenting with early Hodgkin's disease, the chance of death due to their disease is related to prognostic factors, e.g. age, systemic symptoms, ESR bulk, number of sites of disease, histology, haemoglobin, lymphocyte count etc. More than 50% of those with Stage I and IIA disease fall into...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(91)90011-z
更新日期：1991-12-01 00:00:00
abstract：:The myelodysplastic syndromes (MDS) are characterized by cytopenias and acute myeloid leukemia risk. Most MDS patients eventually require transfusion of red blood cells for anemia, placing them at risk of iron overload (IOL). In beta-thalassemia major, transfusional IOL leads to organ dysfunction and death, however, w...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2010.09.003
更新日期：2011-01-01 00:00:00
abstract：:Hemophilia A is an X-linked hereditary bleeding disorder due to the deficiency of coagulation factor VIII (FVIII). According to the degree of FVIII deficiency, mild, moderate or severe forms are recognized. Although patients with mild hemophilia A usually bleed excessively only after trauma or surgery, those with seve...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.06.002
更新日期：2013-07-01 00:00:00
