Abstract：
:Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells. The dysfunction of autophagy proteins hamper the correct erythroid maturation, leading to anemia, the release of immature cells from the bone marrow and other hematological abnormalities. Autophagy plays different roles depending on the type of pathology. In leukemia cells, it has been demonstrated that autophagy could be either detrimental, leading to an increase of the apoptosis rate, or protective, acting as a key process that augments proliferation and survival of cancer cells. Thus, understanding the relationship between autophagy and erythropoiesis opens new avenues for the discovery of biochemical and pharmacological targets and for the development of novel therapeutic approaches.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Grosso R,Fader CM,Colombo MIdoi
10.1016/j.blre.2017.04.001subject
Has Abstractpub_date
2017-09-01 00:00:00pages
300-305issue
5eissn
0268-960Xissn
1532-1681pii
S0268-960X(17)30020-6journal_volume
31pub_type
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