Abstract：
:The process of megakaryocytopoiesis begins with the commitment of a pluripotent hematopoietic stem cell to a differentiation pathway that culminates in the release of mature platelets into the circulation. A variety of megakaryocyte precursor cells have been identified after stem cell commitment has occurred and these may be recognized by their morphologic or immunophenotypic characteristics. Megakaryocytopoiesis is regulated by a number of cytokines with either stimulatory or inhibitory effects and by a variety of cell-cell interactions. Some factors potentiating platelet development promote the proliferation of megakaryocyte progenitor cells, while others result in their maturation. Thrombopoietin, a cytokine with specific megakaryocyte maturational activity recently has been identified as the c-Mpl ligand, and it will be evaluated as a therapeutic agent in the setting of thrombocytopenia due to impaired megakaryocytopoiesis.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Ellis MH,Avraham H,Groopman JEdoi
10.1016/0268-960x(95)90034-9subject
Has Abstractpub_date
1995-03-01 00:00:00pages
1-6issue
1eissn
0268-960Xissn
1532-1681pii
0268-960X(95)90034-9journal_volume
9pub_type
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