Abstract：
:In this review, salient molecular, biochemical and functional features of human interleukin 2 (IL-2), its membrane receptor, and its clinical relevance are outlined. We also describe experimental systems, where observed biological or pharmacological effects of IL-2 could be applied to corresponding clinical situations. In particular, IL-2 has been intensively studied in the context of cancer therapy. We discuss the rationale for the use of IL-2 in cancer treatment and our experience in this area. A better understanding of the IL-2 system and, specifically, the nature of signals transduced through it will allow us to manipulate the immune response in a variety of different ways, resulting in new approaches to investigation of immune responsiveness in general. This may have a profound impact on clinical medicine.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Malkovský M,Sondel PMdoi
10.1016/0268-960x(87)90027-0subject
Has Abstractpub_date
1987-12-01 00:00:00pages
254-66issue
4eissn
0268-960Xissn
1532-1681pii
0268-960X(87)90027-0journal_volume
1pub_type
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