Abstract:
:Major bacterial infections are most commonly associated with agranulocytosis or an abnormality of immunoglobulins or complement. Occasionally, repeated infections cannot be attributed to these relatively common causes. In such cases, a quantitative abnormality in neutrophil function should be sought. Complete evaluation of neutrophil function, including: chemotaxis, adhesion, aggregation, phagocytosis, granule content and degranulation, respiratory burst activity and bacterial killing is expensive and requires the services of a specialized laboratory. However, preliminary screening of a patient with a predisposition towards infection can be carried out using simple and inexpensive methods. These include examination of blood films, chemotaxis assay, NBT test and peroxidase staining. For final diagnosis and determination of genetic transmission and treatment, specific tests are indicated. Investigation of neutrophil functions may be useful for the diagnosis of congenital and acquired neutrophil disorders. These assays may also be useful in research, diagnosis and follow up of non-infectious diseases with active inflammatory component.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Bogomolski-Yahalom V,Matzner Ydoi
10.1016/0268-960x(95)90024-1subject
Has Abstractpub_date
1995-09-01 00:00:00pages
183-90issue
3eissn
0268-960Xissn
1532-1681pii
0268-960X(95)90024-1journal_volume
9pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract::Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.06.001
更新日期:2006-01-01 00:00:00
abstract::After many unsuccessful years of searching, the first pathogenic human retrovirus, the human T-cell leukaemia lymphoma virus (HTLV-I), was reported as recently as 1980 and since that time has been causally linked to the adult T-cell leukaemia lymphoma syndrome. A second HTLV (HTLV-II) isolated shortly afterwards is le...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(88)90010-0
更新日期:1988-12-01 00:00:00
abstract::Myeloid neoplasms like acute myeloid leukemia (AML) originate from genomic disruption, usually in a multi-step fashion. Hematopoietic stem/progenitor cell acquisition of abnormalities in vital cellular processes, when coupled with intrinsic factors such as germline predisposition or extrinsic factors such as the marro...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100760
更新日期:2020-09-22 00:00:00
abstract::Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are c...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.03.001
更新日期:2013-05-01 00:00:00
abstract::The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin i...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(93)90002-l
更新日期:1993-09-01 00:00:00
abstract::Recurrent fetal loss and other placental vascular pathologies of pregnancy have long been associated with antiphospholipid syndrome-an acquired autoimmune thrombophilic state. The number of known heritable thrombophilic disorders has grown rapidly in recent years with the identification of activated protein C resistan...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(97)90013-8
更新日期:1997-06-01 00:00:00
abstract::Early reports would suggest that closely matched UD BMT is an adequate substitute for MSD BMT in children with relapsed ALL. Protagonists of BMT might suggest that UD BMT be used in the absence of a MSD in all cases of BM relapse of ALL. However, recent improvements in chemoradiotherapy schedules have reduced the bene...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(96)90006-5
更新日期:1996-12-01 00:00:00
abstract::The anthracyclines are widely used in the treatment of haematological and non-haematological malignancy and there is now more than 30 years' clinical experience with these agents but despite this, their mechanism of action is incompletely understood. The anthracyclines have been shown to intercalate with DNA and indir...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(97)90020-5
更新日期:1997-12-01 00:00:00
abstract::Nearly 20 years after murine embryonic stem cells (mESC) were isolated, the first report of the derivation of human embryonic stem cells (hESC) in 1998 spawned the field of hESC research [Evans MJ, Kaufman MH, Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292 (5819): 154-6; Thomson ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.01.005
更新日期:2005-11-01 00:00:00
abstract::The innate immune system orchestrated by leukocytes primarily neutrophils, serves to remove dead and dying host cells and to provide protection against invasion by pathogens. Failure of this system results in the onset of sepsis leading to grave consequences for the host. Together with mechanical methods to physically...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2012.09.001
更新日期:2012-11-01 00:00:00
abstract::Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(03)00002-x
更新日期:2003-06-01 00:00:00
abstract::Gaucher disease was first described by Philippe Gaucher in his 1882 medical thesis. Gaucher's original concept was of an unusual epithelioma of the spleen. By the early 1900s, Mandelbaum recognized the systemic nature of the disease. Several children with Gaucher disease were described at the turn of the century, but ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(98)90023-6
更新日期:1998-06-01 00:00:00
abstract::Methaemoglobinaemia arises from the production of non-functional haemoglobin containing oxidised Fe(3+) which results in reduced oxygen supply to the tissues and manifests as cyanosis in the patient. It can develop by three distinct mechanisms: genetic mutation resulting in the presence of abnormal haemoglobin, a defi...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2004.02.001
更新日期:2005-03-01 00:00:00
abstract::The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under crit...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2000.0136
更新日期:2000-12-01 00:00:00
abstract::The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(87)90032-4
更新日期:1987-09-01 00:00:00
abstract::This relatively rare group of disorders may cause quite marked morbidity and occasionally be life-threatening. As their inheritance is largely known accurate information in one family member has obvious benefits to other family members as well as the patient. The identification of the defect is dependent on an accurat...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(90)90042-q
更新日期:1990-09-01 00:00:00
abstract::The diagnostic approach to easy bruising or a suspected mild bleeding disorder includes a careful history and physical examination as well as laboratory investigations. The history should determine whether or not a bleeding disorder exists and help elucidate possible causes. The physical examination should evaluate ev...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(05)80014-1
更新日期:1994-06-01 00:00:00
abstract::Myelodysplastic syndromes (MDS) are a set of oligoclonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis that manifest clinically as anemia, neutropenia, and/or thrombocytopenia of variable severity. The result often is transfusion-dependent anemia, an increased risk of infection or he...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.01.004
更新日期:2005-11-01 00:00:00
abstract::In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral d...
journal_title:Blood reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.blre.2018.05.002
更新日期:2019-01-01 00:00:00
abstract::Universal leucocyte depletion has been implemented in the UK and several other European countries as a precautionary measure against the potential risk of transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Leucocyte depletion had previously only been recommended for a relatively small proportion o...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2000.0130
更新日期:2000-09-01 00:00:00
abstract::Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) represent a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. Biochemical markers include elevated ferritin and triglyce...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2007.05.001
更新日期:2007-09-01 00:00:00
abstract::A working diagnosis of essential thrombocythemia (ET) is made in the presence of nonreactive thrombocytosis and after the exclusion of another chronic myeloid disorder that may mimic ET in its presentation. Clinically, ET is characterized by vasomotor symptoms, thrombohemorrhagic complications, recurrent fetal loss, a...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2001.0158
更新日期:2001-09-01 00:00:00
abstract::Platelets play a major role in primary hemostasis and thrombus formation. After vascular injury, platelets adhere to injured site and rapidly change their shape that switches the resting platelets to active state. Activated platelets aggregate and secrete biologically active intermediate substances that further potent...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2019.05.007
更新日期:2019-09-01 00:00:00
abstract::Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk during early adulthood. The median lifespan for FA patients is approximately 33years. The proteins encoded by the FA genes function together i...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2016.10.002
更新日期:2017-05-01 00:00:00
abstract::Transfusion-associated graft-versus-host disease is a rare but usually fatal complication of transfusion of cellular blood components, caused by multiorgan engraftment and proliferation of donor T lymphocytes. The classical features of skin rash, diarrhoea and hepatitis, along with striking bone-marrow failure, are se...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(95)90016-0
更新日期:1995-12-01 00:00:00
abstract::For many years red blood cells have been described as inert bystanders rather than participants in intercellular signalling, immune function, and inflammatory processes. However, studies are now reporting that red blood cells from healthy individuals regulate immune cell activity and maturation, and red blood cells fr...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2019.100644
更新日期:2020-05-01 00:00:00
abstract::Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2014.09.006
更新日期:2015-01-01 00:00:00
abstract::The improvement in supportive care and the introduction of new therapeutic agents, including lenalidomide and hypomethylating agents, in myelodysplastic syndromes have improved patients' outcomes; however, at the same time, the frequency and epidemiology of infections have changed. Therefore, the great strides in the ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2018.10.002
更新日期:2019-03-01 00:00:00
abstract::Fetal/neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet antigens. Care must be taken in making a correct diagnosis that eliminates other causes of thrombocytopenia that may occur during pregnancy. Biological diagnosis is normally made by platelet genotyping and search...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2001.0187
更新日期:2002-03-01 00:00:00
abstract::In refractory thrombocytopenia one should first evaluate whether the therapeutic approach has more risks to the patient than no treatment at all. The patient may remain relatively asymptomatic and the only incommoding circumstances be cosmetic. Coincidental medical problems such as hypertension and peptic ulceration a...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(88)90020-3
更新日期:1988-09-01 00:00:00