Thrombophilia and fetal loss.

abstract：:Each cell in our body contains a set of tens of thousands of genes, out of which a set of several thousands determines the cell's characteristics. The deciphering of the sequence of the human genome combined with the technical feasibility to simultaneously measure the gene expression levels of thousands of genes had r...

journal_title：Blood reviews

authors： Margalit O,Somech R,Amariglio N,Rechavi G

更新日期：2005-07-01 00:00:00

abstract：:Erythropoiesis is a dynamic process regulated at multiple levels to balance proliferation, differentiation and survival of erythroid progenitors. Ineffective erythropoiesis is a key feature of various diseases, including β-thalassemia. The pathogenic mechanisms leading to ineffective erythropoiesis are complex and sti...

journal_title：Blood reviews

authors： Oikonomidou PR,Rivella S

更新日期：2018-03-01 00:00:00

abstract：:The rate of relapse after allogeneic bone marrow transplantation (BMT) varies between 15 and 60%. New therapeutic strategies are required urgently as no significant results have been obtained with standard chemotherapy. The best results of second allogeneic BMT have been obtained when the interval between the first an...

journal_title：Blood reviews

authors： Boiron JM,Cony-Makhoul P,Mahon FX,Pigneux A,Puntous M,Reiffers J

更新日期：1994-12-01 00:00:00

abstract：:Nearly 20 years after murine embryonic stem cells (mESC) were isolated, the first report of the derivation of human embryonic stem cells (hESC) in 1998 spawned the field of hESC research [Evans MJ, Kaufman MH, Establishment in culture of pluripotential cells from mouse embryos. Nature 1981; 292 (5819): 154-6; Thomson ...

journal_title：Blood reviews

authors： Lerou PH,Daley GQ

更新日期：2005-11-01 00:00:00

abstract：:Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields. This review examines the aetiology of splenomegaly in the developed world, and describes a logical approach to the patient with splenomegaly. In some patients, extensive radiological and laboratory investigations will fa...

journal_title：Blood reviews

authors： Pozo AL,Godfrey EM,Bowles KM

更新日期：2009-05-01 00:00:00

abstract：:Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such ...

journal_title：Blood reviews

authors： Thorell SE,Parry-Jones AR,Punter M,Hurford R,Thachil J

更新日期：2015-01-01 00:00:00

abstract：:The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...

journal_title：Blood reviews

authors： Valls L,Badve C,Avril S,Herrmann K,Faulhaber P,O'Donnell J,Avril N

更新日期：2016-07-01 00:00:00

abstract：:Inherited hemoglobin-related disorders, which include the structural variants (hemoglobin S, C, and E) and the alpha (α)- and beta (β)-thalassemias, affect more than 300,000 children annually, particularly in malaria-endemic regions stretching from sub-Saharan Africa and the Mediterranean to Southeast Asia. Screening ...

journal_title：Blood reviews

authors： Weatherall DJ

更新日期：2012-04-01 00:00:00

abstract：:Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of ...

journal_title：Blood reviews

authors： Rodriguez-Merchan EC

更新日期：2018-03-01 00:00:00

abstract：:ABVD continues to be the standard of care for patients with advanced stage Hodgkin Lymphoma (HL) although escalated BEACOPP has improved survival in one randomized controlled trial (RCT). More intensive regimens have higher rates of acute and late toxicities and this poses significant issues for patients. Consolidatio...

journal_title：Blood reviews

authors： Uhm J,Kuruvilla J

更新日期：2012-07-01 00:00:00

abstract：:Allogeneic stem cell transplantation (alloSCT) is the treatment of choice in the majority of young patients with advanced stages MDS if they have a suitable donor. Since outcome of transplantation is superior for patients with a low blast percentage, this supports the use of chemotherapy prior to transplantation in pa...

journal_title：Blood reviews

authors： de Witte T,Oosterveld M,Muus P

更新日期：2007-01-01 00:00:00

abstract：:We are often faced with the question as to the optimum duration of secondary prophylaxis with oral anticoagulants after an episode of venous thromboembolism. Theoretically if we know the recurrence rate, the case-fatality, the effectiveness of oral anticoagulant therapy, and the rate of fatal haemorrhage on treatment,...

journal_title：Blood reviews

authors： Keeling D

更新日期：2006-05-01 00:00:00

abstract：:Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...

journal_title：Blood reviews

authors： Coppell JA,Brown SA,Perry DJ

更新日期：2003-06-01 00:00:00

abstract：:The clinical relevance of flow cytometry (FC)-based bone marrow involvement (BMI) in B cell non-Hodgkin lymphoma (B-NHL) is not well established. We conducted a systematic review of MEDLINE regarding the use of FC to establish BMI in B-NHL to determine the prevalence of BMI by FC, to understand the interrelation betwe...

journal_title：Blood reviews

authors： Sorigue M,Cañamero E,Miljkovic MD

更新日期：2020-11-08 00:00:00

abstract：:Childhood immune thrombocytopenic purpura (ITP) is acute and generally seasonal in nature, suggesting that infectious or environmental agents may trigger the immune response to produce platelet-reactive autoantibodies 4 to 8 weeks following an infection. In general, the patient is well apart from the diffuse bruising ...

journal_title：Blood reviews

authors： Nugent DJ

更新日期：2002-03-01 00:00:00

abstract：:This relatively rare group of disorders may cause quite marked morbidity and occasionally be life-threatening. As their inheritance is largely known accurate information in one family member has obvious benefits to other family members as well as the patient. The identification of the defect is dependent on an accurat...

journal_title：Blood reviews

authors： Lestas AN,Bellingham AJ

更新日期：1990-09-01 00:00:00

abstract：:Current genomic technologies have immensely improved disease classification and prognostication of major subtypes of B-cell lymphomas. This novel genetic information has not only aided in diagnosis, but has also revealed a landscape of critical molecular events that determine the biological and clinical behavior of a ...

journal_title：Blood reviews

authors： Iqbal J,Naushad H,Bi C,Yu J,Bouska A,Rohr J,Chao W,Fu K,Chan WC,Vose JM

更新日期：2016-03-01 00:00:00

abstract：:Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by a...

journal_title：Blood reviews

authors： Shah N,Andrews J,Goodnough LT

更新日期：2015-09-01 00:00:00

abstract：:Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...

journal_title：Blood reviews

authors： Cottler-Fox M,Lapidot T

更新日期：2006-01-01 00:00:00

abstract：:After many unsuccessful years of searching, the first pathogenic human retrovirus, the human T-cell leukaemia lymphoma virus (HTLV-I), was reported as recently as 1980 and since that time has been causally linked to the adult T-cell leukaemia lymphoma syndrome. A second HTLV (HTLV-II) isolated shortly afterwards is le...

journal_title：Blood reviews

authors： Thomson BJ,Dalgleish AG

更新日期：1988-12-01 00:00:00

abstract：:Patients with myelodysplastic syndrome (MDS) who have more than 10% blasts in their bone marrow have a very short survival. Treatment has not improved for these patients for the past 10 years and supportive care alone is still the gold standard. Intensive chemotherapy for poor prognosis MDS has been little tried, but ...

journal_title：Blood reviews

authors： Hamblin TJ

更新日期：1992-12-01 00:00:00

abstract：:Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-i...

journal_title：Blood reviews

authors： Golebiewska EM,Poole AW

更新日期：2015-05-01 00:00:00

abstract：:Factor X circulates as a serine protease which is converted to the active form at the point of convergence of the intrinsic and extrinsic coagulation pathways. Subsequently, the enzymatic species, factor Xa, is involved in macromolecular complex formation with its cofactor factor Va, a phospholipid surface and calcium...

journal_title：Blood reviews

authors： Hertzberg M

更新日期：1994-03-01 00:00:00

abstract：:Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in patients with cancer. Although some very well validated scores delineate the risk of VTE by cancer subtype and other risk factors, hematologic malignancies are underrepresented in these models. This subgroup represents a unique entity tha...

journal_title：Blood reviews

authors： Kekre N,Connors JM

更新日期：2019-01-01 00:00:00

abstract：:Advances in therapy can essentially be measured using two parameters; introduction of a new agent which benefits an increased number of patients over prevailing treatments or more selective use of an existing drug by matching it to the biologic characteristics associated with response. In reviewing the therapeutic lan...

journal_title：Blood reviews

authors： Schecter J,Galili N,Raza A

更新日期：2012-03-01 00:00:00

abstract：:Transfusion-associated graft-versus-host disease is a rare but usually fatal complication of transfusion of cellular blood components, caused by multiorgan engraftment and proliferation of donor T lymphocytes. The classical features of skin rash, diarrhoea and hepatitis, along with striking bone-marrow failure, are se...

journal_title：Blood reviews

authors： Williamson LM,Warwick RM

更新日期：1995-12-01 00:00:00

abstract：:The binding of haemopoietic growth factors and cytokines to specific receptors triggers a cascade of intracellular events which results in cell proliferation and differentiation. The knowledge of ligand-receptor-signal pathways is not only important in understanding the pathophysiology of malignant disease but also es...

journal_title：Blood reviews

authors： Kaczmarski RS,Mufti GJ

更新日期：1991-09-01 00:00:00

abstract：:Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), for...

journal_title：Blood reviews

authors： Gaudichon J,Jakobczyk H,Debaize L,Cousin E,Galibert MD,Troadec MB,Gandemer V

更新日期：2019-07-01 00:00:00

abstract：:Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow mic...

journal_title：Blood reviews

authors： Xu B,Hu R,Liang Z,Chen T,Chen J,Hu Y,Jiang Y,Li Y

更新日期：2020-12-09 00:00:00

abstract：:The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under crit...

journal_title：Blood reviews

authors： Lappin MB,Campbell JD

更新日期：2000-12-01 00:00:00