Abstract：
:Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-inflammatory factors and other bioactive molecules that are essential regulators in the complex microenvironment of the growing thrombus but also contribute to a number of disease processes. Our understanding of the molecular mechanisms of secretion and the genetic regulation of granule biogenesis still remains incomplete. In this review we summarise our current understanding of the roles of platelet secretion in health and disease, and discuss some of the hypotheses that may explain how platelets may control the release of its many secreted components in a context-specific manner, to allow platelets to play multiple roles in health and disease.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Golebiewska EM,Poole AWdoi
10.1016/j.blre.2014.10.003subject
Has Abstractpub_date
2015-05-01 00:00:00pages
153-62issue
3eissn
0268-960Xissn
1532-1681pii
S0268-960X(14)00085-Xjournal_volume
29pub_type
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