Abstract：
:Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), formerly referred to as ALL-blast sanctuaries. The reason why ALL cells migrate to and stay in these sites is still unclear. In this review, we have attempted to assemble the evidence concerning the microenvironmental factors that could explain why ALL cells reside in such sites. We present criteria that make extramedullary leukemia niches and solid tumor metastatic niches comparable. Indeed, considering extramedullary leukemias as metastases could be a useful approach for proposing more effective treatments. In this context, we conclude with several examples of potential niche-based therapies which could be successfully added to current treatments of ALL.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Gaudichon J,Jakobczyk H,Debaize L,Cousin E,Galibert MD,Troadec MB,Gandemer Vdoi
10.1016/j.blre.2019.04.003subject
Has Abstractpub_date
2019-07-01 00:00:00pages
40-56eissn
0268-960Xissn
1532-1681pii
S0268-960X(18)30078-Xjournal_volume
36pub_type
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