Abstract：
:Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many fields. This review examines the aetiology of splenomegaly in the developed world, and describes a logical approach to the patient with splenomegaly. In some patients, extensive radiological and laboratory investigations will fail to yield a diagnosis: these cases of "isolated" splenomegaly are not uncommon and can be particularly challenging to manage. The risks of serious underlying disease must be balanced against the risks of invasive investigations such as splenic biopsy and diagnostic splenectomy. We discuss the options in isolated splenomegaly and their evidence base, and incorporate them into a management strategy to aid the clinician in cases of diagnostic difficulty.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Pozo AL,Godfrey EM,Bowles KMdoi
10.1016/j.blre.2008.10.001subject
Has Abstractpub_date
2009-05-01 00:00:00pages
105-11issue
3eissn
0268-960Xissn
1532-1681pii
S0268-960X(08)00078-7journal_volume
23pub_type
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