Abstract：
:Current trends in the treatment of patients with Stages I and II Hodgkin's disease are discussed in this review. Recommendations for staging procedures and the updated staging classification are described. Long-term results with extended field radiation therapy overall and in subgroups of patients are detailed. As follow-up and numbers of patients treated with extended field radiation therapy have accrued, prognostic factors, predictive of outcome, have emerged. The evolution of combined modality treatment with chemotherapy and radiation therapy and, more recently, chemotherapy alone for early stage patients is reviewed. Discussion is made of recent programs in various centers to reduce toxicity while maintaining good results. Long-term potential toxicities are described, and recommendations are made for long-term follow-up monitoring.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Straus DJdoi
10.1016/0268-960x(93)90022-vsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
34-42issue
1eissn
0268-960Xissn
1532-1681pii
0268-960X(93)90022-Vjournal_volume
7pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract：:The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under crit...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2000.0136
更新日期：2000-12-01 00:00:00
abstract：:Uncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulop...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2012.06.004
更新日期：2012-09-01 00:00:00
abstract：:DNA analysis has become of practical value in the diagnosis and classification of leukaemias and lymphomas. This is exemplified by the study of lymphoproliferative disorders using immunoglobulin and T-cell receptor gene probes for the determination of clonality and cell lineage. Chromosomal analysis with DNA probes is...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(88)90028-8
更新日期：1988-06-01 00:00:00
abstract：:Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are c...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2013.03.001
更新日期：2013-05-01 00:00:00
abstract：:Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2017.04.001
更新日期：2017-09-01 00:00:00
abstract：:Invasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this comp...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2009.11.003
更新日期：2010-03-01 00:00:00
abstract：:Red blood cell (RBC) alloimmunization is a serious complication of blood transfusions, challenging selection of compatible units for future transfusions. Genetic characteristics may be associated with the risk of RBC alloimmunization and may therefore serve to identify high-risk patients. The aim of this systematic re...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2020.100794
更新日期：2021-01-05 00:00:00
abstract：:Childhood immune thrombocytopenic purpura (ITP) is acute and generally seasonal in nature, suggesting that infectious or environmental agents may trigger the immune response to produce platelet-reactive autoantibodies 4 to 8 weeks following an infection. In general, the patient is well apart from the diffuse bruising ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2001.0177
更新日期：2002-03-01 00:00:00
abstract：:After many unsuccessful years of searching, the first pathogenic human retrovirus, the human T-cell leukaemia lymphoma virus (HTLV-I), was reported as recently as 1980 and since that time has been causally linked to the adult T-cell leukaemia lymphoma syndrome. A second HTLV (HTLV-II) isolated shortly afterwards is le...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(88)90010-0
更新日期：1988-12-01 00:00:00
abstract：:The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(87)90032-4
更新日期：1987-09-01 00:00:00
abstract：:Stem cell factor is an essential haemopoietic progenitor cell growth factor with proliferative and anti-apoptotic functions. Molecular biologists have now dissected some of the various pathways through which this cytokine signals to the nucleus. At the same time, new molecules have become available which can inhibit S...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2001.0167
更新日期：2001-12-01 00:00:00
abstract：:Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF would interfere with the polymerization of sickle hemoglobin while in beta-thalassemia, an increase in gamma-globin chain synthesis would decrease...
journal_title：Blood reviews
pub_type： 杂志文章
doi：10.1016/j.blre.2006.01.002
更新日期：2006-07-01 00:00:00
abstract：:Myelodysplastic syndromes (MDS) are a set of oligoclonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis that manifest clinically as anemia, neutropenia, and/or thrombocytopenia of variable severity. The result often is transfusion-dependent anemia, an increased risk of infection or he...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2005.01.004
更新日期：2005-11-01 00:00:00
abstract：:Extramedullary disease of multiple myeloma (EM) remains a treatment challenge even in the era of new drugs. While many reports analyzing various aspects of EM have been published, mechanism of EM development has not been clarified yet. This review summarizes current knowledge about this clinical entity, including its ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2019.04.002
更新日期：2019-07-01 00:00:00
abstract：:Fetal/neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet antigens. Care must be taken in making a correct diagnosis that eliminates other causes of thrombocytopenia that may occur during pregnancy. Biological diagnosis is normally made by platelet genotyping and search...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1054/blre.2001.0187
更新日期：2002-03-01 00:00:00
abstract：:Allogeneic stem cell transplantation (alloSCT) is the treatment of choice in the majority of young patients with advanced stages MDS if they have a suitable donor. Since outcome of transplantation is superior for patients with a low blast percentage, this supports the use of chemotherapy prior to transplantation in pa...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2006.03.002
更新日期：2007-01-01 00:00:00
abstract：:Cerebral venous thrombosis (CVT) is a condition that can affect all age groups and can often be difficult to diagnose and treat. The difficulties in diagnosis are mainly due to the non-specific presenting features of CVT, which can range from isolated headache and visual or auditory problems, to serious symptoms such ...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2014.09.006
更新日期：2015-01-01 00:00:00
abstract：:Laboratory and clinical data relating to the use of 2'-deoxycoformycin in human disease are reviewed. Pentostatin is an inhibitor of adenosine deaminase, an enzyme that is important for purine metabolism, but more than one mechanism may be involved in its cytotoxic action. Early studies with dCF employed large doses a...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(87)90004-x
更新日期：1987-06-01 00:00:00
abstract：:In this review, salient molecular, biochemical and functional features of human interleukin 2 (IL-2), its membrane receptor, and its clinical relevance are outlined. We also describe experimental systems, where observed biological or pharmacological effects of IL-2 could be applied to corresponding clinical situations...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(87)90027-0
更新日期：1987-12-01 00:00:00
abstract：:The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2016.02.003
更新日期：2016-07-01 00:00:00
abstract：:The process of megakaryocytopoiesis begins with the commitment of a pluripotent hematopoietic stem cell to a differentiation pathway that culminates in the release of mature platelets into the circulation. A variety of megakaryocyte precursor cells have been identified after stem cell commitment has occurred and these...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(95)90034-9
更新日期：1995-03-01 00:00:00
abstract：:In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral d...
journal_title：Blood reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.blre.2018.05.002
更新日期：2019-01-01 00:00:00
abstract：:Transfusion-associated graft-versus-host disease is a rare but usually fatal complication of transfusion of cellular blood components, caused by multiorgan engraftment and proliferation of donor T lymphocytes. The classical features of skin rash, diarrhoea and hepatitis, along with striking bone-marrow failure, are se...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(95)90016-0
更新日期：1995-12-01 00:00:00
abstract：:For the majority of patients presenting with early Hodgkin's disease, the chance of death due to their disease is related to prognostic factors, e.g. age, systemic symptoms, ESR bulk, number of sites of disease, histology, haemoglobin, lymphocyte count etc. More than 50% of those with Stage I and IIA disease fall into...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/0268-960x(91)90011-z
更新日期：1991-12-01 00:00:00
abstract：:A strong association was found to exist between patterns of lymphoid malignancies and socioeconomic status. B-cell lymphomas and T-acute lymphoblastic leukemia are much more prevalent in developing countries where the chances of acquiring infections especially at a younger age are high. B-cell precursor acute lymphati...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/s0268-960x(96)90037-5
更新日期：1996-06-01 00:00:00
abstract：:Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant treatment poses additional challenges in athletes, as these individuals u...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2020.100780
更新日期：2020-11-15 00:00:00
abstract：:Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2005.06.001
更新日期：2006-01-01 00:00:00
abstract：:Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-i...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2014.10.003
更新日期：2015-05-01 00:00:00
abstract：:Platelets play a major role in primary hemostasis and thrombus formation. After vascular injury, platelets adhere to injured site and rapidly change their shape that switches the resting platelets to active state. Activated platelets aggregate and secrete biologically active intermediate substances that further potent...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/j.blre.2019.05.007
更新日期：2019-09-01 00:00:00
abstract：:The anaemia of chronic disease (ACD) is a common haematologic syndrome characterized by hypoferraemia with adequate reticuloendothelial iron stores. Frequently, serum ferritin concentration in these patients is elevated. The pathogenesis of ACD involves abnormalities in red cell survival, the erythropoietic response t...
journal_title：Blood reviews
pub_type： 杂志文章,评审
doi：10.1016/S0268-960X(03)00066-3
更新日期：2004-12-01 00:00:00
