Abstract：
:Stem cell factor is an essential haemopoietic progenitor cell growth factor with proliferative and anti-apoptotic functions. Molecular biologists have now dissected some of the various pathways through which this cytokine signals to the nucleus. At the same time, new molecules have become available which can inhibit SCF signalling. This provides an exciting prospect for the treatment of Kit+ malignancies such as acute myeloblastic leukaemia. The capacity of SCF to synergize with other cytokines has been exploited in the ex vivo expansion of haemopoietic progenitors and dendritic cells, which may also hold therapeutic promise. In this review the last 5 years' literature on these issues is reviewed and collated.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Smith MA,Court EL,Smith JGdoi
10.1054/blre.2001.0167subject
Has Abstractpub_date
2001-12-01 00:00:00pages
191-7issue
4eissn
0268-960Xissn
1532-1681pii
S0268-960X(01)90167-5journal_volume
15pub_type
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