Abstract：
:Invasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this complication, but Aspergillus spp. and Candida spp. are the most frequently isolated micro-organisms; less commonly, infections could be caused by Zygomycetes or other rare molds or yeasts. Several new systemically-administered antifungal agents have been approved for clinical use since 2001; these agents include liposomal amphotericin B, voriconazole, caspofungin, and posaconazole, and they represent a major advance in antifungal therapy and have improved the prognosis of patients with hematological malignancies. This review focuses on therapeutic aspects of the management of fungal infections in hematological patients.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Pagano L,Caira M,Valentini CG,Posteraro B,Fianchi Ldoi
10.1016/j.blre.2009.11.003subject
Has Abstractpub_date
2010-03-01 00:00:00pages
51-61issue
2eissn
0268-960Xissn
1532-1681pii
S0268-960X(09)00068-Xjournal_volume
24pub_type
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