Abstract：
:Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation thrombopoietic agents were recombinant forms of human TPO, and their development was discontinued after prolonged thrombocytopenia due to neutralizing auto-antibodies cross-reacting with endogenous TPO was observed. Second-generation thrombopoiesis-stimulating molecules are now available, which have unique pharmacological properties and no sequence homology to endogenous TPO. Two of these new agents, romiplostim and eltrombopag, have already completed phase III trials in primary immune thrombocytopenia and have been granted marketing authorization for use in this disease. Phase II and III trials with these novel drugs are ongoing in other conditions characterized by thrombocytopenia, such as chemotherapy, chronic liver disease, and the myelodysplastic syndromes. Most of the other second-generation thrombopoietic growth factors are in early phase clinical development.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Stasi R,Bosworth J,Rhodes E,Shannon MS,Willis F,Gordon-Smith ECdoi
10.1016/j.blre.2010.04.002subject
Has Abstractpub_date
2010-07-01 00:00:00pages
179-90issue
4-5eissn
0268-960Xissn
1532-1681pii
S0268-960X(10)00023-8journal_volume
24pub_type
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