Abstract:
:B19 virus is the first human virus to be shown to be a member of the parvovirus genus. This review is concerned with the diseases associated with B19 virus, their nature, pathogenesis and diagnosis. The virus was discovered by chance in blood donors but has been shown to be a common infection of childhood. Infection may be asymptomatic or associated with mild, non-specific symptoms. The most common specific clinical manifestation is an erythematous rash illness which often has the classical features of erythema infectiosum. Often, however, it is described simply as rubelliform and only laboratory tests can distinguish B19 and rubella virus infections. Joint involvement is the most common complication of B19 virus infection occurring especially in adult females. It often involves the joints of the hands and wrists, clears rapidly in most patients but may persist for months or years in a few. B19 virus is also the principle cause of the transient aplastic crisis which complicates chronic haemolytic anaemia. This has been demonstrated repeatedly in sickle cell anaemia and hereditary spherocytosis and in individual cases of other haemolytic anaemias. The pathogenesis of the aplastic crisis is related to the ability of B19 virus to infect and damage early erythroid progenitor cells. Volunteer studies in normal individuals have demonstrated that this is a regular event occurring about a week after infection via the respiratory tract. Rash illness and joint involvement occur 7 to 10 days later and are presumably immune mediated. Diagnosis of B19 virus infection can be achieved by detection of the viraemia (aplastic crisis) or by detection of virus specific IgM antibody (all diseases).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Blood Revjournal_title
Blood reviewsauthors
Pattison JRdoi
10.1016/0268-960x(87)90020-8subject
Has Abstractpub_date
1987-03-01 00:00:00pages
58-64issue
1eissn
0268-960Xissn
1532-1681pii
0268-960X(87)90020-8journal_volume
1pub_type
杂志文章,评审相关文献
BLOOD REVIEWS文献大全abstract::In patients with hemophilia, osteoporosis is frequently observed for which the etiology remains unclear. The aim of this paper is to review the available experimental evidence indicating the presence of this disorder in patients with hemophilia, explore the potential mechanisms which may lead to reduced bone mineral d...
journal_title:Blood reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.blre.2018.05.002
更新日期:2019-01-01 00:00:00
abstract::The clinical relevance of flow cytometry (FC)-based bone marrow involvement (BMI) in B cell non-Hodgkin lymphoma (B-NHL) is not well established. We conducted a systematic review of MEDLINE regarding the use of FC to establish BMI in B-NHL to determine the prevalence of BMI by FC, to understand the interrelation betwe...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2020.100778
更新日期:2020-11-08 00:00:00
abstract::The transfusion approach to massive hemorrhage has continually evolved since it began in the early 1900s. It started with fresh whole blood and currently consists of virtually exclusive use of component and crystalloid therapy. Recent US military experience has reinvigorated the debate on what the most optimal transfu...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2009.07.003
更新日期:2009-11-01 00:00:00
abstract::The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin i...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(93)90002-l
更新日期:1993-09-01 00:00:00
abstract::Upon activation, platelets secrete more than 300 active substances from their intracellular granules. Platelet dense granule components, such as ADP and polyphosphates, contribute to haemostasis and coagulation, but also play a role in cancer metastasis. α-Granules contain multiple cytokines, mitogens, pro- and anti-i...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2014.10.003
更新日期:2015-05-01 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is a disease of older patients and median age at diagnosis is 72 years. This older group is under-represented in clinical trials, (median age 58-62 years). Here we review background data on incidence, survival, definitions of older age, fitness criteria, frailty and co-morbidities. I...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2011.09.002
更新日期:2012-01-01 00:00:00
abstract::Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(03)00002-x
更新日期:2003-06-01 00:00:00
abstract::Hemophilia A is an X-linked hereditary bleeding disorder due to the deficiency of coagulation factor VIII (FVIII). According to the degree of FVIII deficiency, mild, moderate or severe forms are recognized. Although patients with mild hemophilia A usually bleed excessively only after trauma or surgery, those with seve...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.06.002
更新日期:2013-07-01 00:00:00
abstract::The process of megakaryocytopoiesis begins with the commitment of a pluripotent hematopoietic stem cell to a differentiation pathway that culminates in the release of mature platelets into the circulation. A variety of megakaryocyte precursor cells have been identified after stem cell commitment has occurred and these...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(95)90034-9
更新日期:1995-03-01 00:00:00
abstract::Notch signaling can regulate both hematopoietic progenitors and alloimmune T cells in the setting of allogeneic bone marrow or hematopoietic cell transplantation (allo-HCT). Ex vivo culture of multipotent blood progenitors with immobilized Delta-like ligands induces supraphysiological Notch signals and can markedly en...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.08.001
更新日期:2013-11-01 00:00:00
abstract::Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor (TF)-mediated coagulation. In atherosclerotic plaques TFPI co-localizes with TF, where it is believed to play an important role in attenuating TF activity. Findings in animal models such as TFPI knockout models and gene transfer models are c...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.03.001
更新日期:2013-05-01 00:00:00
abstract::Universal leucocyte depletion has been implemented in the UK and several other European countries as a precautionary measure against the potential risk of transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Leucocyte depletion had previously only been recommended for a relatively small proportion o...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2000.0130
更新日期:2000-09-01 00:00:00
abstract::MicroRNAs (miRNAs) have become one of the hottest topics in biology over recent years, but remarkably have only been formally recognized for just over 10 years. These endogenously produced short (19-24 nt) non-coding RNAs have introduced an entirely new paradigm in our understanding of gene control and it is now evide...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.04.002
更新日期:2013-05-01 00:00:00
abstract::Extracorporeal phototherapy (ECP) is a therapeutic approach based on the biological effect of psoralen 8-methoxypsoralen (8-MOP) and ultraviolet light A (UVA) on mononuclear cells collected by apheresis, and reinfused into the patient. Photopheresis is widely used for the treatment of patients with advanced cutaneous ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2001.0155
更新日期:2001-06-01 00:00:00
abstract::Gaucher disease was first described by Philippe Gaucher in his 1882 medical thesis. Gaucher's original concept was of an unusual epithelioma of the spleen. By the early 1900s, Mandelbaum recognized the systemic nature of the disease. Several children with Gaucher disease were described at the turn of the century, but ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/s0268-960x(98)90023-6
更新日期:1998-06-01 00:00:00
abstract::Parenteral arsenic trioxide (ATO) has been firmly established as a standard therapy for acute promyelocytic leukemia (APL). Despite widespread use of oral arsenicals in medicine historically, they had disappeared from modern pharmacopeia until oral ATO was redeveloped in Hong Kong in 2000. Since then, over 200 patient...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2015.11.004
更新日期:2016-05-01 00:00:00
abstract::In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and sign...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2013.12.001
更新日期:2014-01-01 00:00:00
abstract::Erythropoiesis is a dynamic process regulated at multiple levels to balance proliferation, differentiation and survival of erythroid progenitors. Ineffective erythropoiesis is a key feature of various diseases, including β-thalassemia. The pathogenic mechanisms leading to ineffective erythropoiesis are complex and sti...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2017.10.001
更新日期:2018-03-01 00:00:00
abstract::Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by a...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2015.02.001
更新日期:2015-09-01 00:00:00
abstract::The term epigenetics defines a heritable alteration in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that foster epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and post-translational histone modifications. Disruption of the balanced epi...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2005.01.006
更新日期:2006-01-01 00:00:00
abstract::Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), for...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2019.04.003
更新日期:2019-07-01 00:00:00
abstract::DNA analysis has become of practical value in the diagnosis and classification of leukaemias and lymphomas. This is exemplified by the study of lymphoproliferative disorders using immunoglobulin and T-cell receptor gene probes for the determination of clonality and cell lineage. Chromosomal analysis with DNA probes is...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(88)90028-8
更新日期:1988-06-01 00:00:00
abstract::Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation thrombopoietic agents were recombinant forms of human TPO, and their developme...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2010.04.002
更新日期:2010-07-01 00:00:00
abstract::Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) represent a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. Biochemical markers include elevated ferritin and triglyce...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2007.05.001
更新日期:2007-09-01 00:00:00
abstract::Advances in molecular genetic understanding of disease processes has been extended to a number of phagocytic disorders. Most of these disorders were extensively characterized at the functional and protein level prior to cloning of the relevant genes. Nucleotide sequence data has been essential for establishing the mec...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(89)90004-0
更新日期:1989-06-01 00:00:00
abstract::Stem cell factor is an essential haemopoietic progenitor cell growth factor with proliferative and anti-apoptotic functions. Molecular biologists have now dissected some of the various pathways through which this cytokine signals to the nucleus. At the same time, new molecules have become available which can inhibit S...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1054/blre.2001.0167
更新日期:2001-12-01 00:00:00
abstract::The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2016.02.003
更新日期:2016-07-01 00:00:00
abstract::von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur. Especially in patients with severe VWD, joint bleeds have been described in up to 45% of the patients. Recurrent hemarthroses can lead to joint destruction which is the mai...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2012.09.002
更新日期:2012-11-01 00:00:00
abstract::Drug-induced agranulocytosis is a highly individualized and unexpected reaction to specific drugs. It may be due to immunogenic or cytotoxic factors. Most instances are produced by a poorly understood immune response to immunogenic drugs. Others are associated with direct suppression of marrow committed stem cells by ...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/0268-960x(90)90002-a
更新日期:1990-12-01 00:00:00
abstract::Methaemoglobinaemia arises from the production of non-functional haemoglobin containing oxidised Fe(3+) which results in reduced oxygen supply to the tissues and manifests as cyanosis in the patient. It can develop by three distinct mechanisms: genetic mutation resulting in the presence of abnormal haemoglobin, a defi...
journal_title:Blood reviews
pub_type: 杂志文章,评审
doi:10.1016/j.blre.2004.02.001
更新日期:2005-03-01 00:00:00