Evaluation of mild bleeding disorders and easy bruising.

Abstract:

:The diagnostic approach to easy bruising or a suspected mild bleeding disorder includes a careful history and physical examination as well as laboratory investigations. The history should determine whether or not a bleeding disorder exists and help elucidate possible causes. The physical examination should evaluate evidence of bleeding and identify systemic illness. The laboratory investigation should include both screening and more specific diagnostic tests depending on the results of the screening tests and clinical findings. The review will provide a framework for generating a differential diagnosis in patients with suspected bleeding disorders and will categorize them into abnormalities of coagulation factors, platelets and those related to blood vessels and supporting tissues.

journal_name

Blood Rev

journal_title

Blood reviews

authors

Sham RL,Francis CW

doi

10.1016/s0268-960x(05)80014-1

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

98-104

issue

2

eissn

0268-960X

issn

1532-1681

pii

S0268-960X(05)80014-1

journal_volume

8

pub_type

杂志文章,评审
  • Hemophilic arthropathy in patients with von Willebrand disease.

    abstract::von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur. Especially in patients with severe VWD, joint bleeds have been described in up to 45% of the patients. Recurrent hemarthroses can lead to joint destruction which is the mai...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2012.09.002

    authors: van Galen KP,Mauser-Bunschoten EP,Leebeek FW

    更新日期:2012-11-01 00:00:00

  • Results of programmes for antenatal detection of thalassemia in reducing the incidence of the disorder.

    abstract::The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(87)90032-4

    authors: Cao A

    更新日期:1987-09-01 00:00:00

  • Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues.

    abstract::Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently above 85% due to huge improvements in treatment. However, 15-20% of children still experience relapses. Relapses can either occur in the bone marrow or at extramedullary sites, such as gonads or the central nervous system (CNS), for...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2019.04.003

    authors: Gaudichon J,Jakobczyk H,Debaize L,Cousin E,Galibert MD,Troadec MB,Gandemer V

    更新日期:2019-07-01 00:00:00

  • Mobilizing the older patient with myeloma.

    abstract::Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2005.06.001

    authors: Cottler-Fox M,Lapidot T

    更新日期:2006-01-01 00:00:00

  • MicroRNAs in hematological malignancies.

    abstract::MicroRNAs (miRNAs) have become one of the hottest topics in biology over recent years, but remarkably have only been formally recognized for just over 10 years. These endogenously produced short (19-24 nt) non-coding RNAs have introduced an entirely new paradigm in our understanding of gene control and it is now evide...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2013.04.002

    authors: Lawrie CH

    更新日期:2013-05-01 00:00:00

  • FDG-PET imaging in hematological malignancies.

    abstract::The majority of aggressive lymphomas is characterized by an up regulated glycolytic activity, which enables the visualization by F-18 FDG-PET/CT. One-stop hybrid FDG-PET/CT combines the functional and morphologic information, outperforming both, CT and FDG-PET as separate imaging modalities. This has resulted in sever...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2016.02.003

    authors: Valls L,Badve C,Avril S,Herrmann K,Faulhaber P,O'Donnell J,Avril N

    更新日期:2016-07-01 00:00:00

  • Management of venous thromboembolism in athletes.

    abstract::Venous thromboembolism (VTE) is a common condition with high associated morbidity and mortality. Athletes have unique VTE risk factors compared with the general population, and may have a higher than anticipated risk of thrombosis. Anticoagulant treatment poses additional challenges in athletes, as these individuals u...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2020.100780

    authors: Swan D,Carter-Brzezinski L,Thachil J

    更新日期:2020-11-15 00:00:00

  • The fundamental role of epigenetics in hematopoietic malignancies.

    abstract::The term epigenetics defines a heritable alteration in gene expression without an accompanying change in primary DNA sequence. Two major mechanisms that foster epigenetic changes are DNA methylation at cytosine bases within a CpG dinucleotide and post-translational histone modifications. Disruption of the balanced epi...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2005.01.006

    authors: Galm O,Herman JG,Baylin SB

    更新日期:2006-01-01 00:00:00

  • Controversies surrounding iron chelation therapy for MDS.

    abstract::The myelodysplastic syndromes (MDS) are characterized by cytopenias and acute myeloid leukemia risk. Most MDS patients eventually require transfusion of red blood cells for anemia, placing them at risk of iron overload (IOL). In beta-thalassemia major, transfusional IOL leads to organ dysfunction and death, however, w...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2010.09.003

    authors: Leitch HA

    更新日期:2011-01-01 00:00:00

  • Hemophagocytic syndromes.

    abstract::Hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, HLH) represent a severe hyperinflammatory condition with the cardinal symptoms prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. Biochemical markers include elevated ferritin and triglyce...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2007.05.001

    authors: Janka GE

    更新日期:2007-09-01 00:00:00

  • Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.

    abstract::Fanconi anemia (FA) is a rare autosomal and X-linked genetic disease characterized by congenital abnormalities, progressive bone marrow failure (BMF), and increased cancer risk during early adulthood. The median lifespan for FA patients is approximately 33years. The proteins encoded by the FA genes function together i...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2016.10.002

    authors: Mamrak NE,Shimamura A,Howlett NG

    更新日期:2017-05-01 00:00:00

  • Immune checkpoint inhibition in myeloid malignancies: Moving beyond the PD-1/PD-L1 and CTLA-4 pathways.

    abstract::Immune checkpoint inhibitors (ICI) have yielded mixed but largely underwhelming results in clinical trials in patients with acute myeloid leukemia and myelodysplastic syndromes to date. However, increasing understanding of the immunologic landscape, potential biomarkers for benefits, and mechanisms of resistance, as w...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2020.100709

    authors: Bewersdorf JP,Shallis RM,Zeidan AM

    更新日期:2020-05-23 00:00:00

  • Disorders of oxidised haemoglobin.

    abstract::Methaemoglobinaemia arises from the production of non-functional haemoglobin containing oxidised Fe(3+) which results in reduced oxygen supply to the tissues and manifests as cyanosis in the patient. It can develop by three distinct mechanisms: genetic mutation resulting in the presence of abnormal haemoglobin, a defi...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2004.02.001

    authors: Percy MJ,McFerran NV,Lappin TR

    更新日期:2005-03-01 00:00:00

  • Screening and genetic diagnosis of haemoglobin disorders.

    abstract::The inherited haemoglobinopathies are large group of disorders that include the thalassaemias and sickle cell disease. Carrier detection methods must be able to detect alpha-, beta- and deltabeta-thalassaemias, HPFH disorders and haemoglobin variants. Carrier diagnosis involves the accurate measurement of MCH, MCV, Hb...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(02)00061-9

    authors: Old JM

    更新日期:2003-03-01 00:00:00

  • The unstable haemoglobins.

    abstract::The unstable haemoglobin haemolytic anaemias result from the presence in the red cell of a structurally abnormal haemoglobin variant. There are many mutations producing unstable haemoglobins; most are single amino acid replacements that affect a few key areas of the haemoglobin structure. A wide range of haemoglobin i...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(93)90002-l

    authors: Williamson D

    更新日期:1993-09-01 00:00:00

  • Alloimmune thrombocytopenia of the fetus and the newborn.

    abstract::Fetal/neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet antigens. Care must be taken in making a correct diagnosis that eliminates other causes of thrombocytopenia that may occur during pregnancy. Biological diagnosis is normally made by platelet genotyping and search...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1054/blre.2001.0187

    authors: Kaplan C

    更新日期:2002-03-01 00:00:00

  • Treatment of the neutropenia of Felty syndrome.

    abstract::This review sets out to synthesize and critically evaluate the current reported data regarding therapeutic options for the neutropenia associated with Felty syndrome (Felty neutropenia). A MEDLINE search and bibliographies from recent reviews were used to identify trials and case reports that provided sufficient data ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(96)90024-7

    authors: Rashba EJ,Rowe JM,Packman CH

    更新日期:1996-09-01 00:00:00

  • The golden age for patients in their golden years: The progressive upheaval of age and the treatment of newly-diagnosed acute myeloid leukemia.

    abstract::Most acute myeloid leukemia (AML) patients will be aged more than 65 years. Chronological aging is accompanied by decreasing stem cell and solid organ reserve as well as an increased incidence of medical comorbidity. For the older patient with AML, these patient-specific factors are compounded by an association with c...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2019.100639

    authors: Shallis RM,Boddu PC,Bewersdorf JP,Zeidan AM

    更新日期:2020-03-01 00:00:00

  • Stem cell factor: laboratory and clinical aspects.

    abstract::Stem cell factor is an essential haemopoietic progenitor cell growth factor with proliferative and anti-apoptotic functions. Molecular biologists have now dissected some of the various pathways through which this cytokine signals to the nucleus. At the same time, new molecules have become available which can inhibit S...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1054/blre.2001.0167

    authors: Smith MA,Court EL,Smith JG

    更新日期:2001-12-01 00:00:00

  • Treatment of early stage Hodgkin's disease.

    abstract::Current trends in the treatment of patients with Stages I and II Hodgkin's disease are discussed in this review. Recommendations for staging procedures and the updated staging classification are described. Long-term results with extended field radiation therapy overall and in subgroups of patients are detailed. As fol...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(93)90022-v

    authors: Straus DJ

    更新日期:1993-03-01 00:00:00

  • MDS: Refining existing therapy through improved biologic insights.

    abstract::Advances in therapy can essentially be measured using two parameters; introduction of a new agent which benefits an increased number of patients over prevailing treatments or more selective use of an existing drug by matching it to the biologic characteristics associated with response. In reviewing the therapeutic lan...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2011.11.001

    authors: Schecter J,Galili N,Raza A

    更新日期:2012-03-01 00:00:00

  • Intensive chemotherapy in myelodysplastic syndromes.

    abstract::Patients with myelodysplastic syndrome (MDS) who have more than 10% blasts in their bone marrow have a very short survival. Treatment has not improved for these patients for the past 10 years and supportive care alone is still the gold standard. Intensive chemotherapy for poor prognosis MDS has been little tried, but ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(92)90017-k

    authors: Hamblin TJ

    更新日期:1992-12-01 00:00:00

  • Hepcidin and anaemia.

    abstract::The anaemia of chronic disease (ACD) is a common haematologic syndrome characterized by hypoferraemia with adequate reticuloendothelial iron stores. Frequently, serum ferritin concentration in these patients is elevated. The pathogenesis of ACD involves abnormalities in red cell survival, the erythropoietic response t...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/S0268-960X(03)00066-3

    authors: Means RT Jr

    更新日期:2004-12-01 00:00:00

  • Drug-induced agranulocytosis. Peripheral destruction of polymorphonuclear leukocytes and their marrow precursors.

    abstract::Drug-induced agranulocytosis is a highly individualized and unexpected reaction to specific drugs. It may be due to immunogenic or cytotoxic factors. Most instances are produced by a poorly understood immune response to immunogenic drugs. Others are associated with direct suppression of marrow committed stem cells by ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(90)90002-a

    authors: Pisciotta AV

    更新日期:1990-12-01 00:00:00

  • Myeloid-derived suppressor cells in lymphoma: The good, the bad and the ugly.

    abstract::Lymphomas cause significant morbidity and mortality worldwide. A substantial number of patients ultimately relapse after standard treatment. However, the efficacy of these therapies can be counteracted by the patients' immune system, more specifically by myeloid-derived suppressor cells (MDSC). MDSC are a heterogeneou...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2018.04.006

    authors: Betsch A,Rutgeerts O,Fevery S,Sprangers B,Verhoef G,Dierickx D,Beckers M

    更新日期:2018-11-01 00:00:00

  • Targeting platelet receptor function in thrombus formation: the risk of bleeding.

    abstract::In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and sign...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2013.12.001

    authors: Swieringa F,Kuijpers MJ,Heemskerk JW,van der Meijden PE

    更新日期:2014-01-01 00:00:00

  • Current therapeutic approaches to fungal infections in immunocompromised hematological patients.

    abstract::Invasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this comp...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2009.11.003

    authors: Pagano L,Caira M,Valentini CG,Posteraro B,Fianchi L

    更新日期:2010-03-01 00:00:00

  • The role of pentostatin (2'-deoxycoformycin, dCF) in the management of lymphoproliferative malignancies.

    abstract::Laboratory and clinical data relating to the use of 2'-deoxycoformycin in human disease are reviewed. Pentostatin is an inhibitor of adenosine deaminase, an enzyme that is important for purine metabolism, but more than one mechanism may be involved in its cytotoxic action. Early studies with dCF employed large doses a...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(87)90004-x

    authors: Spiers AS

    更新日期:1987-06-01 00:00:00

  • The definition and epidemiology of non-transfusion-dependent thalassemia.

    abstract::Inherited hemoglobin-related disorders, which include the structural variants (hemoglobin S, C, and E) and the alpha (α)- and beta (β)-thalassemias, affect more than 300,000 children annually, particularly in malaria-endemic regions stretching from sub-Saharan Africa and the Mediterranean to Southeast Asia. Screening ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/S0268-960X(12)70003-6

    authors: Weatherall DJ

    更新日期:2012-04-01 00:00:00

  • Veno-occlusive disease: cytokines, genetics, and haemostasis.

    abstract::Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(03)00002-x

    authors: Coppell JA,Brown SA,Perry DJ

    更新日期:2003-06-01 00:00:00