Abstract：
:Four decades ago, two staging systems were developed to help stratify CLL into different prognostic categories. These systems, the Rai and the Binet staging, depended entirely on abnormal exam findings and evidence of anemia and thrombocytopenia. Better understanding of biologic, genetic, and molecular characteristics of CLL have contributed to better appreciating its clinical heterogeneity. New prognostic models, the GCLLSG prognostic index and the CLL-IPI, emerged. They incorporate biologic and genetic information related to CLL and are capable of predicting survival outcomes and cases anticipated to need therapy earlier in the disease course. Accordingly, these newer models are helping develop better informed surveillance strategies and ultimately tailor treatment intensity according to presence (or lack thereof) of certain prognostic markers. This represents a step towards personalizing care of CLL patients. We anticipate that as more prognostic factors continue to be identified, the GCLLSG prognostic index and CLL-IPI models will undergo further revisions.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Mina A,Sandoval Sus J,Sleiman E,Pinilla-Ibarz J,Awan FT,Kharfan-Dabaja MAdoi
10.1016/j.blre.2017.10.003subject
Has Abstractpub_date
2018-03-01 00:00:00pages
159-166issue
2eissn
0268-960Xissn
1532-1681pii
S0268-960X(17)30053-Xjournal_volume
32pub_type
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