Abstract：
:T cells are implicated in the effective control of chronic myeloid leukemia (CML). Recently, several clinical observations supported by laboratory data, indicate the presence of CML-specific T cells. Many proteins potentially act as leukemia-specific antigens for MHC-restricted cytotoxicity in CML. These include the bcr-abl fusion protein, myeloid-specific differentiation antigens and minor histocompatibility antigens. There is recent evidence to suggest that bcr-abl junctional peptides are capable of eliciting both CD4 and CD8 responses in normal healthy donors and in patients with CML. Moreover, T cell lines can be generated that react with autologous or HLA-matched fresh CML cells, suggesting that the bcr-abl fusion protein can be processed and expressed in the MHC cell surface molecules. Clinical trials exploiting the new understanding of the immunology of CML are underway.
journal_name
Blood Revjournal_title
Blood reviewsauthors
Pinilla-Ibarz J,Cathcart K,Scheinberg DAdoi
10.1054/blre.2000.0127subject
Has Abstractpub_date
2000-06-01 00:00:00pages
111-20issue
2eissn
0268-960Xissn
1532-1681pii
S0268-960X(00)90127-9journal_volume
14pub_type
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