Iron toxicity - Its effect on the bone marrow.

Abstract:

:Excess iron can be extremely toxic for the body and may cause organ damage in the absence of iron chelation therapy. Preclinical studies on the role of free iron on bone marrow function have shown that iron toxicity leads to the accumulation of reactive oxygen species, affects the expression of genes coding for proteins that regulate hematopoiesis, and disrupts hematopoiesis. These effects could be partially attenuated by iron-chelation treatment with deferasirox, suggesting iron toxicity may have a negative impact on the hematopoietic microenvironment. Iron toxicity is of concern in transfusion-dependent patients. Importantly, iron chelation with deferasirox can cause the loss of transfusion dependency and may induce hematological responses, although the mechanisms through which deferasirox exerts this action are currently unknown. This review will focus on the possible mechanisms of toxicity of free iron at the bone marrow level and in the bone marrow microenvironment.

journal_name

Blood Rev

journal_title

Blood reviews

authors

Isidori A,Borin L,Elli E,Latagliata R,Martino B,Palumbo G,Pilo F,Loscocco F,Visani G,Cianciulli P

doi

10.1016/j.blre.2018.04.004

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

473-479

issue

6

eissn

0268-960X

issn

1532-1681

pii

S0268-960X(17)30150-9

journal_volume

32

pub_type

杂志文章,评审
  • DNA hypomethylation therapy for hemoglobin disorders: molecular mechanisms and clinical applications.

    abstract::Reactivation of fetal hemoglobin (HbF) expression is an important therapeutic option in patients with hemoglobin disorders. In sickle cell disease (SCD), an increase in HbF would interfere with the polymerization of sickle hemoglobin while in beta-thalassemia, an increase in gamma-globin chain synthesis would decrease...

    journal_title:Blood reviews

    pub_type: 杂志文章

    doi:10.1016/j.blre.2006.01.002

    authors: Fathallah H,Atweh GF

    更新日期:2006-07-01 00:00:00

  • Hemophagocytic syndromes--an update.

    abstract::Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome and not an independent disease. HLH represents the extreme end of a severe uncontrolled hyperinflammatory reaction that can occur in many underlying conditions. Genetic forms of HLHs are due to defects in transport, processing an...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2014.03.002

    authors: Janka GE,Lehmberg K

    更新日期:2014-07-01 00:00:00

  • The emerging role of red blood cells in cytokine signalling and modulating immune cells.

    abstract::For many years red blood cells have been described as inert bystanders rather than participants in intercellular signalling, immune function, and inflammatory processes. However, studies are now reporting that red blood cells from healthy individuals regulate immune cell activity and maturation, and red blood cells fr...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2019.100644

    authors: Karsten E,Herbert BR

    更新日期:2020-05-01 00:00:00

  • Veno-occlusive disease: cytokines, genetics, and haemostasis.

    abstract::Hepatic veno-occlusive disease (VOD) is a major cause of morbidity and mortality following high dose cytotoxic therapy for stem cell transplantation (SCT). Pre-existing liver damage, SCT-related therapy, and genetic polymorphisms all appear to increase the risk of developing VOD. Studies of biological markers during S...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(03)00002-x

    authors: Coppell JA,Brown SA,Perry DJ

    更新日期:2003-06-01 00:00:00

  • Transfusions for anemia in adult and pediatric patients with malignancies.

    abstract::Anemia is present in over two-thirds of patients with malignant hematological disorders. The etiology of anemia predominates from ineffective erythropoiesis from marrow infiltration, cytokine related suppression, erythropoietin suppression, and vitamin deficiency; ineffective erythropoiesis is further exacerbated by a...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2015.02.001

    authors: Shah N,Andrews J,Goodnough LT

    更新日期:2015-09-01 00:00:00

  • Mobilizing the older patient with myeloma.

    abstract::Although hematopoietic progenitor/stem cells (HPC) have been used for autologous transplants for approximately 25 years, it is only recently that we have begun to finally understand the factors which play important roles in causing these cells to leave their marrow niches and circulate in the blood. Still less is unde...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2005.06.001

    authors: Cottler-Fox M,Lapidot T

    更新日期:2006-01-01 00:00:00

  • Hepcidin and anaemia.

    abstract::The anaemia of chronic disease (ACD) is a common haematologic syndrome characterized by hypoferraemia with adequate reticuloendothelial iron stores. Frequently, serum ferritin concentration in these patients is elevated. The pathogenesis of ACD involves abnormalities in red cell survival, the erythropoietic response t...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/S0268-960X(03)00066-3

    authors: Means RT Jr

    更新日期:2004-12-01 00:00:00

  • Molecular diagnosis of haematological neoplasms.

    abstract::DNA analysis has become of practical value in the diagnosis and classification of leukaemias and lymphomas. This is exemplified by the study of lymphoproliferative disorders using immunoglobulin and T-cell receptor gene probes for the determination of clonality and cell lineage. Chromosomal analysis with DNA probes is...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(88)90028-8

    authors: Fey MF,Wainscoat JS

    更新日期:1988-06-01 00:00:00

  • Congenital platelet disorders.

    abstract::Congenital platelet disorders include thrombocytopathies and thrombocytopenias, which often occur in association. Thrombocytopathies constitute a model for exploring platelet physiology at the molecular level: adhesion, activation, release phenomena, aggregation. Further advances in understanding thrombocytopenias now...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(88)90004-5

    authors: Bellucci S,Caen JP

    更新日期:1988-03-01 00:00:00

  • Swallowing a bitter pill-oral arsenic trioxide for acute promyelocytic leukemia.

    abstract::Parenteral arsenic trioxide (ATO) has been firmly established as a standard therapy for acute promyelocytic leukemia (APL). Despite widespread use of oral arsenicals in medicine historically, they had disappeared from modern pharmacopeia until oral ATO was redeveloped in Hong Kong in 2000. Since then, over 200 patient...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2015.11.004

    authors: Torka P,Al Ustwani O,Wetzler M,Wang ES,Griffiths EA

    更新日期:2016-05-01 00:00:00

  • The regulation of megakaryocytopoiesis.

    abstract::The process of megakaryocytopoiesis begins with the commitment of a pluripotent hematopoietic stem cell to a differentiation pathway that culminates in the release of mature platelets into the circulation. A variety of megakaryocyte precursor cells have been identified after stem cell commitment has occurred and these...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(95)90034-9

    authors: Ellis MH,Avraham H,Groopman JE

    更新日期:1995-03-01 00:00:00

  • Screening and genetic diagnosis of haemoglobin disorders.

    abstract::The inherited haemoglobinopathies are large group of disorders that include the thalassaemias and sickle cell disease. Carrier detection methods must be able to detect alpha-, beta- and deltabeta-thalassaemias, HPFH disorders and haemoglobin variants. Carrier diagnosis involves the accurate measurement of MCH, MCV, Hb...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(02)00061-9

    authors: Old JM

    更新日期:2003-03-01 00:00:00

  • Drug-induced agranulocytosis. Peripheral destruction of polymorphonuclear leukocytes and their marrow precursors.

    abstract::Drug-induced agranulocytosis is a highly individualized and unexpected reaction to specific drugs. It may be due to immunogenic or cytotoxic factors. Most instances are produced by a poorly understood immune response to immunogenic drugs. Others are associated with direct suppression of marrow committed stem cells by ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(90)90002-a

    authors: Pisciotta AV

    更新日期:1990-12-01 00:00:00

  • Extracorporeal photopheresis: a review.

    abstract::Extracorporeal phototherapy (ECP) is a therapeutic approach based on the biological effect of psoralen 8-methoxypsoralen (8-MOP) and ultraviolet light A (UVA) on mononuclear cells collected by apheresis, and reinfused into the patient. Photopheresis is widely used for the treatment of patients with advanced cutaneous ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1054/blre.2001.0155

    authors: Oliven A,Shechter Y

    更新日期:2001-06-01 00:00:00

  • The cytokine receptor superfamily.

    abstract::The binding of haemopoietic growth factors and cytokines to specific receptors triggers a cascade of intracellular events which results in cell proliferation and differentiation. The knowledge of ligand-receptor-signal pathways is not only important in understanding the pathophysiology of malignant disease but also es...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(91)90036-c

    authors: Kaczmarski RS,Mufti GJ

    更新日期:1991-09-01 00:00:00

  • Management of refractory idiopathic thrombocytopenia.

    abstract::In refractory thrombocytopenia one should first evaluate whether the therapeutic approach has more risks to the patient than no treatment at all. The patient may remain relatively asymptomatic and the only incommoding circumstances be cosmetic. Coincidental medical problems such as hypertension and peptic ulceration a...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(88)90020-3

    authors: Firkin BG,Hunt HA,Jane SM

    更新日期:1988-09-01 00:00:00

  • The place of radiotherapy in stage I and IIA Hodgkin's disease (or radiotherapy revisited).

    abstract::For the majority of patients presenting with early Hodgkin's disease, the chance of death due to their disease is related to prognostic factors, e.g. age, systemic symptoms, ESR bulk, number of sites of disease, histology, haemoglobin, lymphocyte count etc. More than 50% of those with Stage I and IIA disease fall into...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(91)90011-z

    authors: Maher EJ

    更新日期:1991-12-01 00:00:00

  • Alloimmune thrombocytopenia of the fetus and the newborn.

    abstract::Fetal/neonatal alloimmune thrombocytopenia results from a maternal alloimmunization against fetal platelet antigens. Care must be taken in making a correct diagnosis that eliminates other causes of thrombocytopenia that may occur during pregnancy. Biological diagnosis is normally made by platelet genotyping and search...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1054/blre.2001.0187

    authors: Kaplan C

    更新日期:2002-03-01 00:00:00

  • Enzyme therapy for Gaucher disease: the first 5 years.

    abstract::Gaucher disease was first described by Philippe Gaucher in his 1882 medical thesis. Gaucher's original concept was of an unusual epithelioma of the spleen. By the early 1900s, Mandelbaum recognized the systemic nature of the disease. Several children with Gaucher disease were described at the turn of the century, but ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(98)90023-6

    authors: Grabowski GA,Leslie N,Wenstrup R

    更新日期:1998-06-01 00:00:00

  • Hemophilic arthropathy in patients with von Willebrand disease.

    abstract::von Willebrand disease (VWD) affects approximately 1% of the population. Joint bleeds are not a predominant symptom of VWD, however they do occur. Especially in patients with severe VWD, joint bleeds have been described in up to 45% of the patients. Recurrent hemarthroses can lead to joint destruction which is the mai...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2012.09.002

    authors: van Galen KP,Mauser-Bunschoten EP,Leebeek FW

    更新日期:2012-11-01 00:00:00

  • Biochemistry of factor X.

    abstract::Factor X circulates as a serine protease which is converted to the active form at the point of convergence of the intrinsic and extrinsic coagulation pathways. Subsequently, the enzymatic species, factor Xa, is involved in macromolecular complex formation with its cofactor factor Va, a phospholipid surface and calcium...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(94)90007-8

    authors: Hertzberg M

    更新日期:1994-03-01 00:00:00

  • Thrombophilia and fetal loss.

    abstract::Recurrent fetal loss and other placental vascular pathologies of pregnancy have long been associated with antiphospholipid syndrome-an acquired autoimmune thrombophilic state. The number of known heritable thrombophilic disorders has grown rapidly in recent years with the identification of activated protein C resistan...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0268-960x(97)90013-8

    authors: Brenner B,Blumenfeld Z

    更新日期:1997-06-01 00:00:00

  • Neutrophil extracellular traps (NETs) and infection-related vascular dysfunction.

    abstract::The innate immune system orchestrated by leukocytes primarily neutrophils, serves to remove dead and dying host cells and to provide protection against invasion by pathogens. Failure of this system results in the onset of sepsis leading to grave consequences for the host. Together with mechanical methods to physically...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2012.09.001

    authors: Gardiner EE,Andrews RK

    更新日期:2012-11-01 00:00:00

  • Results of programmes for antenatal detection of thalassemia in reducing the incidence of the disorder.

    abstract::The characteristics and the effectiveness of programmes designed to prevent beta-thalassemia major present in high frequency in several areas of the world such as Cyprus, Greece and Sardinia are reviewed. All these programmes are based on heterozygote detection, counselling and foetal diagnosis. The target population ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(87)90032-4

    authors: Cao A

    更新日期:1987-09-01 00:00:00

  • Pathophysiology of aplastic anaemia.

    abstract::It is the conventional opinion that acquired aplastic anaemia is a heterogenous disease including basically different conditions, such as idiopathic or virus induced pancytopenia, toxic-allergic marrow damage or autoimmunity. Here, an alternative concept is proposed, according to which aplastic anaemia is one disease,...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(90)90032-n

    authors: Nissen-Druey C

    更新日期:1990-06-01 00:00:00

  • Thrombopoietic agents.

    abstract::Thrombopoietin (TPO) is the key cytokine involved in thrombopoiesis, and is the endogenous ligand for the thrombopoietin receptor that is expressed on the surface of platelets, megakaryocytes, and megakaryocytic precursors. First-generation thrombopoietic agents were recombinant forms of human TPO, and their developme...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2010.04.002

    authors: Stasi R,Bosworth J,Rhodes E,Shannon MS,Willis F,Gordon-Smith EC

    更新日期:2010-07-01 00:00:00

  • A logical approach to the investigation of red cell enzymopathies.

    abstract::This relatively rare group of disorders may cause quite marked morbidity and occasionally be life-threatening. As their inheritance is largely known accurate information in one family member has obvious benefits to other family members as well as the patient. The identification of the defect is dependent on an accurat...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/0268-960x(90)90042-q

    authors: Lestas AN,Bellingham AJ

    更新日期:1990-09-01 00:00:00

  • The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy.

    abstract::The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under crit...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1054/blre.2000.0136

    authors: Lappin MB,Campbell JD

    更新日期:2000-12-01 00:00:00

  • Autophagy: A necessary event during erythropoiesis.

    abstract::Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such as ribosomes and mitochondria (mitophagy) allowing the correct formation of mature red blood cells...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2017.04.001

    authors: Grosso R,Fader CM,Colombo MI

    更新日期:2017-09-01 00:00:00

  • Genomic signatures in B-cell lymphoma: How can these improve precision in diagnosis and inform prognosis?

    abstract::Current genomic technologies have immensely improved disease classification and prognostication of major subtypes of B-cell lymphomas. This novel genetic information has not only aided in diagnosis, but has also revealed a landscape of critical molecular events that determine the biological and clinical behavior of a ...

    journal_title:Blood reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.blre.2015.08.002

    authors: Iqbal J,Naushad H,Bi C,Yu J,Bouska A,Rohr J,Chao W,Fu K,Chan WC,Vose JM

    更新日期:2016-03-01 00:00:00