Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni.


:The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.


Mem Inst Oswaldo Cruz


Fidelis TAA,Brasileiro-Filho G,Santos HH,Vasconcelos-Santos DV,Parreiras PM,Coelho PMZ,Araujo N,Chaud MV,Lambertucci JR




Has Abstract


2019-01-01 00:00:00












  • Serological detection of St. Louis encephalitis virus and West Nile virus in equines from Santa Fe, Argentina.

    abstract::St. Louis encephalitis virus (SLEV) and West Nile virus (WNV) present ecological and antigenic similarities and are responsible for serious human diseases. In addition, WNV is a significant pathogen in terms of equine health. The purpose of our study was to analyse the seroprevalence of SLEV and WNV in equine sera col...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Tauro L,Marino B,Diaz LA,Lucca E,Gallozo D,Spinsanti L,Contigiani M

    更新日期:2012-06-01 00:00:00

  • N-terminal amino acid sequences of the major outer membrane proteins from a Neisseria meningitidis group B strain isolated in Brazil.

    abstract::The four dominant outer membrane proteins (46, 38, 33 and 28 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in a semi-purified preparation of vesicle membranes of a Neisseria meningitidis (N44/89, B:4:P1.15:P5.5,7) strain isolated in Brazil. The N-terminal amino acid sequenc...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: De Simone SG,Soares SA,Souza AL,Danelli MG

    更新日期:1996-01-01 00:00:00

  • Clinical spectrum of uncomplicated malaria in semi-immune Amazonians: beyond the " symptomatic " vs " asymptomatic " dichotomy.

    abstract::We analyzed prospectively 326 laboratory-confirmed, uncomplicated malarial infections (46.3% due to Plasmodium vivax, 35.3% due to P. falciparum, and 18.4% mixed-species infections) diagnosed in 162 rural Amazonians aged 5-73 years. Thirteen symptoms (fever, chills, sweating, headache, myalgia, arthralgia, abdominal p...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: da Silva-Nunes M,Ferreira MU

    更新日期:2007-06-01 00:00:00

  • Urban Chagas disease in children and women in primary care centres in Buenos Aires, Argentina.

    abstract::The primary objective of this study was to estimate the prevalence of this disease in women of childbearing age and children treated at health centres in underserviced areas of the city of Buenos Aires. Demographic and Chagas disease status data were collected. Samples for Chagas disease serology were obtained on filt...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,多中心研究


    authors: Moscatelli G,Berenstein A,Tarlovsky A,Siniawski S,Biancardi M,Ballering G,Moroni S,Schwarcz M,Hernández S,García-Bournissen F,Cozzi AE,Freilij H,Altcheh J

    更新日期:2015-08-01 00:00:00

  • Characteristics of the biological cycle of Lutzomyia evandroi Costa Lima & Antunes, 1936 (Diptera: Psychodidae) under experimental conditions.

    abstract::Lutzomyia evandroi Costa Lima and Antunes, 1936 is found in Rio Grande do Norte, northeastern Brazil, in areas of visceral and mucocutaneous leishmaniasis and follows the same geographic distribution of L. longipalpis. The biological cycle, oviposition, morphological and behavioral characteristics of the species were ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: de Melo Ximenes Mde F,Maciel JC,Jerônimo SM

    更新日期:2001-08-01 00:00:00

  • Mast cell changes in experimental diabetes: focus on attenuation of allergic events.

    abstract::The prevalence of atopic diseases and diabetes is increasing worldwide though the concurrence of these pathologies in individual patients is found less frequent than it would be predicted. Moreover, co-existence of diabetes and allergy is generally marked by attenuation of their respective symptoms, and effective trea...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Carvalho VF,Barreto EO,Cordeiro RS,Lagente V,Martins MA,e Silva PM

    更新日期:2005-03-01 00:00:00

  • A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information.

    abstract::The current drug options for the treatment of chronic Chagas disease have not been sufficient and high hopes have been placed on the use of genomic data from the human parasite Trypanosoma cruzi to identify new drug targets and develop appropriate treatments for both acute and chronic Chagas disease. However, the lack...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Alves-Ferreira M,Guimarães AC,Capriles PV,Dardenne LE,Degrave WM

    更新日期:2009-12-01 00:00:00

  • Assessing key safety concerns of a Wolbachia-based strategy to control dengue transmission by Aedes mosquitoes.

    abstract::Mosquito-borne diseases such as dengue fever, chikungunya or malaria affect millions of people each year and control solutions are urgently needed. An international research program is currently being developed that relies on the introduction of the bacterial endosymbiont Wolbachia pipientis into Aedes aegypti to cont...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Popovici J,Moreira LA,Poinsignon A,Iturbe-Ormaetxe I,McNaughton D,O'Neill SL

    更新日期:2010-12-01 00:00:00

  • Molecular characterisation of newly identified HIV-1 infections in Curitiba, Brazil: preponderance of clade C among males with recent infections.

    abstract::As in many areas of Brazil, the AIDS epidemic in Curitiba is relatively stable, but surveillance is important to support public policy. The molecular characteristics of HIV may be instrumental for monitoring epidemic trends. We evaluated plasma HIV-1 RNA (n = 37) from 38 cases presenting with positive serology, who we...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ferreira JL,Thomaz M,Rodrigues R,Harrad D,Oliveira CM,Oliveira CA,Batista JP,Ito TS,Brigido LF

    更新日期:2008-12-01 00:00:00

  • Prevalence and genotypes of GB virus C/hepatitis G virus among blood donors in Central Brazil.

    abstract::A survey was conducted in a blood donor population of Central Brazil aiming to investigate the prevalence of GB virus C (GBV-C)/hepatitis G virus (HGV) infection and also to analyze the virus genotypes distribution. A total of 241 voluntary blood donors were interviewed at the State Blood Bank in Goiânia, State of Goi...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Oliveira LA,Martins RM,Carneiro MA,Teles SA,Silva SA,Cardoso DD,Lampe E,Yoshida CF

    更新日期:2002-10-01 00:00:00

  • Toxoplasma gondii infection induces lipid metabolism alterations in the murine host.

    abstract::Host lipids have been implicated in the pathogenesis of Toxoplasma gondii infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zer...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Milovanović I,Vujanić M,Klun I,Bobić B,Nikolić A,Ivović V,Trbovich AM,Djurković-Djaković O

    更新日期:2009-03-01 00:00:00

  • Determinants of human immunodeficiency virus (HIV) prevalence in homosexual and bisexual men screened for admission to a cohort study of HIV negatives in Belo Horizonte, Brazil: Project Horizonte.

    abstract::Project Horizonte, an open cohort of homosexual and bisexual human immunodeficiency virus (HIV-1) negative men, is a component of the AIDS Vaccine Program, in Belo Horizonte, Minas Gerais, Brazil. The objective of this study was to compare volunteers testing HIV positive at cohort entry with a sample of those who test...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Carneiro M,Cardoso FA,Greco M,Oliveira E,Andrade J,Greco DB,Antunes CM

    更新日期:2003-04-01 00:00:00

  • Adult abundance, biting behavior and parity of Anopheles aquasalis, Curry 1932 in two malarious areas of Sucre State, Venezuela.

    abstract::The principal vector of malaria in eastern Venezuela, Anopheles aquasalis, is exophagic and exophilic. Control using indoor insecticide house sprays has failed to lower the number of malaria cases. Therefore, studies were initiated in two villages of the eastern coastal state of Sucre to better understand this vector'...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Berti J,Zimmerman R,Amarista J

    更新日期:1993-07-01 00:00:00

  • Pharmacokinetic profile of tert-butylaminoethanethiol.

    abstract::A preliminary study of the pharmacokinetic parameters of t-Butylaminoethanethiol (TBAESH) was performed after administration of a single dose (35 mg/kg) either orally or intravenously. Plasma or blood samples were treated with dithiothreitol, perchloric acid and, after filtration, submitted to further purification wit...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Andrade MH,Freire AC,Nelson DL

    更新日期:1990-07-01 00:00:00

  • Role of divalent cations, pH, cytoskeleton components and surface charge on the adhesion of Trichomonas vaginalis to a polystyrene substrate.

    abstract::The process of adhesion of three different strains of Trichomonas vaginalis to a polystyrene substrate was analysed. The process of adhesion was dependent on the time of incubation and the pH of the phosphate-buffered solution (PBS) in which the parasites were suspended. The highest indices of adhesion were observed a...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Silva Filho FC,Elias CA,De Souza W

    更新日期:1987-07-01 00:00:00

  • Evaluation of a monoclonal antibody affinity purified antigen for zymodeme specific serological diagnosis of Trypanosoma cruzi infection.

    abstract::Theoretically, serological assays with affinity purified marker antigens can allow strain-specific diagnosis even when parasites cannot be retrieved from an infected host. A Trypanosoma cruzi antigen was purified by affinity chromatography using a zymodeme (Z) 2 specific monoclonal antibody (2E2C11). An indirect enzym...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Schechter M

    更新日期:1987-01-01 00:00:00

  • Two new Culicoides of the paraensis species group (Diptera: Ceratopogonidae) from the Amazonian region of Peru.

    abstract::Two new species of the Culicoides paraensis species group, C. diversus Felippe-Bauer and C. peruvianus Felippe-Bauer, are described and illustrated based on female specimens from Amazonian region of Peru. A systematic key, table with numerical characters of females, and distribution of species of the C. paraensis grou...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Felippe-Bauer ML,Cáceres AG,Silva CS,Valderrama-Bazan W,Gonzales-Perez A

    更新日期:2003-12-01 00:00:00

  • Recent advances and prospective researches on molecular epidemiology of dengue viruses.

    abstract::The determination of amino acid changes in the envelope protein by direct sequencing of either genomic RNA or PCR-amplified cDNA fragments provides useful informations for assessing the genetic variability and the geographic distribution of the actually most widespread dengue-2 serotype. The possible link of variation...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章,评审


    authors: Deubel V

    更新日期:1992-01-01 00:00:00

  • Cotylophoron Travassosi sp. n. (Trematoda--Paramphistomidae) from cattle.

    abstract::A new species of the genus Cotylophoron (Trematoda--Paramphistomidae) --Cotylophoron travassosi sp. n.--is described. The measurements of the worm and its structures are compared with the valid known species. ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Costa HM,Guimaráes MP

    更新日期:1992-01-01 00:00:00

  • Ecology of sandflies (Diptera:Psychodidae) in a restricted focus of cutaneous leishmaniasis in northern Venezuela. III. Seasonal fluctuation.

    abstract::A one year-long study (March 1979-March 1980) was carried out at San Esteban, an endemic focus of cutaneous leishmaniasis in Northern Venezuela, with the aim of observing the seasonal fluctuation of the local phlebotomine sandflies species. The influence of climatic factors (temperature, relative humidity and rainfall...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Feliciangeli MD

    更新日期:1987-04-01 00:00:00

  • Sequence analysis of coding DNA fragments of pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Odisha, India.

    abstract::The global emergence and spread of malaria parasites resistant to antimalarial drugs is the major problem in malaria control. The genetic basis of the parasite's resistance to the antimalarial drug chloroquine (CQ) is well-documented, allowing for the analysis of field isolates of malaria parasites to address evolutio...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Sutar SK,Gupta B,Ranjit M,Kar SK,Das A

    更新日期:2011-02-01 00:00:00

  • Improved reverse transcription-polymerase chain reaction assay for the detection of flaviviruses with semi-nested primers for discrimination between dengue virus serotypes and Zika virus.

    abstract::BACKGROUND The genus Flavivirus includes a variety of medically important viruses, including dengue virus (DENV) and Zika virus (ZIKV), which are most prevalent in Brazil. Because the clinical profile of patients affected by different DENV serotypes or ZIKV may be similar, the development of new methods that facilitat...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Nunes AR,Alves BEB,Pereira HW,Nascimento YM,Morais IC,Fernandes JV,Araújo JM,Lanza DC

    更新日期:2018-01-01 00:00:00

  • Biology of three species of North American Triatominae (Hemiptera: Reduviidae: Triatominae) fed on rabbits.

    abstract::Aspects related to hatching, lifetime, number of blood meals for molting, mortality, feeding time, and postfeeding defecation delay were evaluated and compared in each instar of three North American Triatominae: Triatoma gerstaeckeri, Triatoma lecticularia and Triatoma protracta, all of them fed on rabbits. No signifi...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Martínez-Ibarra JA,Alejandre-Aguilar R,Paredes-González E,Martínez-Silva MA,Solorio-Cibrián M,Nogueda-Torres B,Trujillo-Contreras F,Novelo-López M

    更新日期:2007-12-01 00:00:00

  • Adult and nymphs of Microtriatoma trinidadensis (Lent, 1951) (Hemiptera: Reduviidae) caught from peridomestic environment in Bolivia.

    abstract::This is the first report of adult and nymphs (20 nymphs of all stages and 4 adults) of Microtriatoma trinidadensis (Lent 1951) (Hemiptera: Reduviidae: Triatominae) collected in peridomestic environment, in the department of La Paz, Bolivia. These specimens were associated to Rhodnius stali Lent, Jurberg & Galvão 1993....

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: De la Riva J,Matias A,Torrez M,Martínez E,Dujardin JP

    更新日期:2001-10-01 00:00:00

  • The vitellogenin gene family of Aedes aegypti.

    abstract::We have been interested in identifying genes that play a role in reproduction of the mosquito Aedes aegypti. Our interests are currently focused on the vitellogenin genes which in the mosquito are expressed only in the fat body in response to the insect steroid hormone, 20-hydroxyecdysone. Four of the five vitellogeni...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Hamblin MT,Marx JL,Wolfner MF,Hagedorn HH

    更新日期:1987-01-01 00:00:00

  • Uptake of macromolecules by cercariae during skin penetration and transformation to schistosomula (Schistosoma mansoni).

    abstract::Here, we observed the uptake of membrane-impermeant molecules by cercariae as they penetrate the skin and are transformed into schistosomula. We propose that membrane-impermeant molecules, Lucifer Yellow, Propidium iodide and Hoechst 33258 enter the parasite through both thenephridiopore and the surface membrane and t...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Thornhill J,Kusel J,Oliviera FA,Ribeiro F,Lima SF,Coelho PM,McVeigh P,Mattos AC

    更新日期:2010-07-01 00:00:00

  • Crossing experiments detect genetic incompatibility among populations of Triatoma brasiliensis Neiva, 1911 (Heteroptera, Reduviidae, Triatominae).

    abstract::Triatoma brasiliensis is composed of at least four geographic populations (brasiliensis, melanica, macromelasoma, and juazeiro) that have distinct chromatic, morphologic, biologic and ecologic patterns, and genetic composition. Reciprocal crosses between all pairwise combinations were carried out in order to evaluate ...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Costa J,Almeida CE,Dujardin JP,Beard CB

    更新日期:2003-07-01 00:00:00

  • DNA probes for distinguishing Psychodopygus wellcomei from Psychodopygus complexus (Diptera:Psychodidae).

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    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Ready PD,Lainson R,Shaw JJ,Souza AA

    更新日期:1991-01-01 00:00:00

  • BCG Moreau Rio de Janeiro: an oral vaccine against tuberculosis--review.

    abstract::The vaccine Bacillus of Calmette Guérin (BCG) was originally developed in France as an oral vaccine against tuberculosis. The oral use of this vaccine was replaced by the parenteral route in almost all countries after the Lubeck disaster. In contrast, Brazil retained the oral delivery of the vaccine until the mid-seve...

    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 历史文章,杂志文章,评审


    authors: Benévolo-de-Andrade TC,Monteiro-Maia R,Cosgrove C,Castello-Branco LR

    更新日期:2005-08-01 00:00:00

  • Clonal multidrug-resistant Corynebacterium striatum within a nosocomial environment, Rio de Janeiro, Brazil.

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    journal_title:Memorias do Instituto Oswaldo Cruz

    pub_type: 杂志文章


    authors: Baio PV,Mota HF,Freitas AD,Gomes DL,Ramos JN,Sant'Anna LO,Souza MC,Camello TC,Hirata Junior R,Vieira VV,Mattos-Guaraldi AL

    更新日期:2013-02-01 00:00:00