Modifying Risk of Aneuploidy with a Positive Cell-Free Fetal DNA Result.

Abstract:

:Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental trophoblasts, allowing for identification of the DNA associated with the fetal component of the placenta. Using simple venipuncture in the outpatient setting, this cell-free, extracellular fetal DNA can be isolated in the maternal serum from a single blood draw as early as the seventh week of gestation.

journal_name

Clin Lab Med

authors

Long AA,Abuhamad AZ,Warsof SL

doi

10.1016/j.cll.2016.01.018

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

249-59

issue

2

eissn

0272-2712

issn

1557-9832

pii

S0272-2712(16)30018-X

journal_volume

36

pub_type

杂志文章,评审
  • Point-of-care testing for disasters: needs assessment, strategic planning, and future design.

    abstract::Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2009.07.014

    authors: Kost GJ,Hale KN,Brock TK,Louie RF,Gentile NL,Kitano TK,Tran NK

    更新日期:2009-09-01 00:00:00

  • Role of free radicals in cancer and atherosclerosis.

    abstract::As aerobic creatures, normal living requires that not only are human beings exposed to oxygen but are dependent on oxygen. Humans have evolved mechanisms to cope with living in an aerobic environment; however, modern humans may be more exposed to oxidant stresses. Much indirect evidence implicates reactive oxygen spec...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Bankson DD,Kestin M,Rifai N

    更新日期:1993-06-01 00:00:00

  • Validating the performance of QC procedures.

    abstract::A methodology for computing the maximum expected number of unreliable patient results produced because of an out-of-control condition for a given quality control strategy is presented along with strategies for changing the expected number of unreliable results produced and reported. The expected number of unreliable p...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2012.11.006

    authors: Yundt-Pacheco J,Parvin CA

    更新日期:2013-03-01 00:00:00

  • Information for medical decision making. Improving our laboratory reports.

    abstract::The primary product of the laboratory is information. Greater attention should be devoted to how laboratory reports are presented to ensure that information is being conveyed effectively to the clinician. Different reporting techniques, including test-by-test, interim, cumulative, and completed accession reports, are ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Aller RD

    更新日期:1991-03-01 00:00:00

  • Yellow fever: a reemerging threat.

    abstract::Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas, which principally affects humans and nonhuman primates and is transmitted via the bite of infected mosquitoes. Yellow fever virus (YFV) can cause devastating epidemics of potentially fatal, hemorrhagic disease. Despite mass v...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2010.01.001

    authors: Gardner CL,Ryman KD

    更新日期:2010-03-01 00:00:00

  • Fine needle aspiration biopsy of the liver. Principal diagnostic challenges.

    abstract::Fine needle aspiration biopsy (FNAB) is the diagnostic procedure of choice for evaluation of liver lesions. Although primarily applied to malignant disease, it is also used in the evaluation of benign conditions. Improvements in imaging techniques and advances in cytologic interpretations, as well as production of new...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Pitman MB

    更新日期:1998-09-01 00:00:00

  • The promise and reality of pharmacogenetics in psychiatry.

    abstract::Existing psychotropic medications for the treatment of mental illnesses, including antidepressants, mood stabilizers, and antipsychotics, are clinically suboptimal. They are effective in only a subset of patients or produce partial responses, and they are often associated with debilitating side effects that discourage...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2010.07.004

    authors: Zandi PP,Judy JT

    更新日期:2010-12-01 00:00:00

  • Lipoprotein-associated phospholipase A2.

    abstract::Lipoprotein-associated phospholipase A2 (LP-PLA2) is an emerging inflammatory marker that is used to assess the risk for cardiovascular disease (CVD) and associated events. Several epidemiologic studies have demonstrated an independent association between plasma Lp-PLA2 concentration and risk for cardiovascular events...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2006.06.003

    authors: McConnell JP,Hoefner DM

    更新日期:2006-09-01 00:00:00

  • Temporal data mining.

    abstract::Large-scale clinical databases provide a detailed perspective on patient phenotype in disease and the characteristics of health care processes. Important information is often contained in the relationships between the values and timestamps of sequences of clinical data. The analysis of clinical time sequence data acro...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2007.10.005

    authors: Post AR,Harrison JH Jr

    更新日期:2008-03-01 00:00:00

  • Ebola Virus Disease: An Update on Epidemiology, Symptoms, Laboratory Findings, Diagnostic Issues, and Infection Prevention and Control Issues for Laboratory Professionals.

    abstract::The 2014 to 2016 Ebola virus disease (EVD), through the sheer size of the outbreak and combined experience within both resource-rich and resource-poor settings, allowed for more information to be gained about the clinical and pathologic features of EVD. This review highlights the range of aspects of EVD that the autho...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.01.003

    authors: Brown CS,Mepham S,Shorten RJ

    更新日期:2017-06-01 00:00:00

  • The interrelationships of the gut microbiome and inflammation in colorectal carcinogenesis.

    abstract::The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional interplay of the gut microbiome with inflammat...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2014.08.002

    authors: Cho M,Carter J,Harari S,Pei Z

    更新日期:2014-12-01 00:00:00

  • Therapy other than reverse transcriptase inhibitors for HIV infection.

    abstract::Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Kaplan JC,Hirsch MS

    更新日期:1994-06-01 00:00:00

  • Antimicrobic susceptibility testing. A personal perspective.

    abstract::The development of antimicrobic susceptibility testing is outlined with particular reference to standardization of procedures and organizational developments that have led to substantially improved performance. Special problems continue to be posed by increased proportions of opportunistic pathogens and newly recogniz...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Sherris JC

    更新日期:1989-06-01 00:00:00

  • Microalbuminuria.

    abstract::Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Hindmarsh JT

    更新日期:1988-09-01 00:00:00

  • Cholesterol profile measurement by vertical auto profile method.

    abstract::Vertical auto profile (VAP) method is a direct single test for measuring comprehensive lipoprotein cholesterol profile. It is based on a well-established method of ultracentrifugation that uses vertical rotor and single density gradient spin. VAP provides cholesterol concentrations of total lipoprotein, high-density l...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2006.07.004

    authors: Kulkarni KR

    更新日期:2006-12-01 00:00:00

  • The effect of benchmarking clinical practice with the clinical laboratory. An institutional case study.

    abstract::The improvement of quality in clinical care can greatly benefit form continuous benchmarking with information based on laboratory data. To be most effective, the information is best provided in the form of real-time disease management decision support. Such an approach requires advances in the implementation of hospit...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Bissell MG

    更新日期:1999-12-01 00:00:00

  • Diagnosis, classification, and course of myelodysplastic syndromes.

    abstract::The myelodysplastic syndromes are bone marrow stem cell disorders that result in disorderly and ineffective hematopoiesis. They are prognostically heterogenous. Approximately one third of cases evolve to acute myeloid leukemia. Many additional cases terminate in severe bone marrow failure. The French-American-British ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: McKenna RW,Allison PM

    更新日期:1990-12-01 00:00:00

  • Extracellular Vesicles Move Toward Use in Clinical Laboratories.

    abstract::Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological un...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.05.004

    authors: Strotman LN,Linder MW

    更新日期:2016-09-01 00:00:00

  • Serologic evaluation of renal status.

    abstract::Mechanisms of immunologic injury causing glomerulonephritis are based on immune complex or autoantibody deposition with activation of complement. Circulating immune complex disease can be diagnosed and monitored with improved assays for immune complexes, DNA antibodies, complement levels, and complement activation pro...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: McPherson RA

    更新日期:1993-03-01 00:00:00

  • Drugs of abuse testing in a psychiatric outpatient service.

    abstract::Drug testing of patients in a psychiatric outpatient service is an effective way to identify patients who relapse into renewed use of drugs of abuse and in monitoring the effectiveness of ongoing medical and psychological therapy. Most of this testing involves the analysis of urine specimens with immunoassays. Hair te...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Shearer DS,Baciewicz GJ,Kwong TC

    更新日期:1998-12-01 00:00:00

  • Fellowship Training for the Future Clinical Microbiology Laboratory Director.

    abstract::Formal medical and public health microbiology (MPHM) fellowship programs play a key role in preparing future clinical microbiology laboratory directors for their leadership and management responsibilities. Given the continually evolving MPHM field, fellowships must remain adaptable to changes in the field, providing t...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2020.08.009

    authors: Pritt BS,Bowler CA,Theel ES

    更新日期:2020-12-01 00:00:00

  • Considerations for monitoring cyclosporine in transplant recipients.

    abstract::Cyclosporine (CsA) monitoring has remained controversial since the advent of the use of CsA in organ transplantation in the early 1980s. This article attempts to clarify for the clinical laboratory worker many of the vagaries associated with CsA monitoring by considering choice of sample matrix, the nature of metaboli...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Napoli KL,Kahan BD

    更新日期:1991-09-01 00:00:00

  • Molecular genetic advances in neurodegenerative disorders.

    abstract::Advances in molecular genetics have had a major impact on our understanding of the pathogenesis of neurologic disorders. This article discusses molecular genetic contributions to our knowledge of Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease, as well as their implications for diagnosis a...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Aguilera AJ

    更新日期:1995-12-01 00:00:00

  • Free drug monitoring.

    abstract::The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These lev...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Chan S,Gerson B

    更新日期:1987-06-01 00:00:00

  • Lead poisoning--Part II. Effects and assay.

    abstract::This second part of the review article compiles currently available information on the effects of lead poisoning. Also examined are the available options for assay, the procedures for collection of samples, and the available methods for the estimation of lead in the collected samples. ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Philip AT,Gerson B

    更新日期:1994-09-01 00:00:00

  • Diagnostic Molecular Microbiology: A 2018 Snapshot.

    abstract::Molecular biological techniques have evolved expeditiously and in turn have been applied to the detection of infectious disease. Maturation of these technologies and their coupling with related technological advancement in fluorescence, electronics, digitization, nanodynamics, and sensors among others have afforded cl...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2018.02.004

    authors: Fairfax MR,Bluth MH,Salimnia H

    更新日期:2018-06-01 00:00:00

  • Apoprotein measurements and their clinical application.

    abstract::The apoproteins structurally are closely associated with specific lipoproteins, for example, apoprotein B with VLDL and LDL and apoprotein A-I with HDL. The levels of these apoproteins provide information about the plasma concentrations and metabolism of the lipoproteins with which they are associated. The levels of a...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Albers JJ,Brunzell JD,Knopp RH

    更新日期:1989-03-01 00:00:00

  • Blood film preparation and staining procedures.

    abstract::The blood film is one of the world's most widely and frequently used tests and has undergone remarkably few changes since its introduction in the late 1800s. This article gives direction and some standardization in the preparation of blood films used for morphologic evaluation in the clinical laboratory. Methodologies...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0272-2712(03)00064-7

    authors: Houwen B

    更新日期:2002-03-01 00:00:00

  • Laboratory diagnosis of malaria.

    abstract::Diagnostic procedures for the detection of malaria differ considerably depending on the aims of evaluation. The current requirements of any laboratory procedure for general application to the detection and diagnosis of malaria include: sensitivity, specificity, simplicity in application, unambiguous interpretation, an...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Makler MT,Gibbins B

    更新日期:1991-12-01 00:00:00

  • Spectrum of ischemic heart disease and the role of biochemical markers.

    abstract::An exciting era exists as a result of the introduction of novel markers of myocardial damage. The prognostic implications of troponins, even in the setting of "minor myocardial damage," are potentially of immense value to patient care. We need to take the next step and assess the outcomes of interventions in these set...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Tymchak WJ,Armstrong PW

    更新日期:1997-12-01 00:00:00