Abstract:
:Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental trophoblasts, allowing for identification of the DNA associated with the fetal component of the placenta. Using simple venipuncture in the outpatient setting, this cell-free, extracellular fetal DNA can be isolated in the maternal serum from a single blood draw as early as the seventh week of gestation.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Long AA,Abuhamad AZ,Warsof SLdoi
10.1016/j.cll.2016.01.018subject
Has Abstractpub_date
2016-06-01 00:00:00pages
249-59issue
2eissn
0272-2712issn
1557-9832pii
S0272-2712(16)30018-Xjournal_volume
36pub_type
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