Laboratory Information Systems.

abstract：:Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger...

journal_title：Clinics in laboratory medicine

authors： Shi M,Nguyen P,Jevremovic D

更新日期：2017-12-01 00:00:00

abstract：:Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit...

journal_title：Clinics in laboratory medicine

authors： Kaplan JC,Hirsch MS

更新日期：1994-06-01 00:00:00

abstract：:Drug testing of patients in a psychiatric outpatient service is an effective way to identify patients who relapse into renewed use of drugs of abuse and in monitoring the effectiveness of ongoing medical and psychological therapy. Most of this testing involves the analysis of urine specimens with immunoassays. Hair te...

journal_title：Clinics in laboratory medicine

authors： Shearer DS,Baciewicz GJ,Kwong TC

更新日期：1998-12-01 00:00:00

abstract：:Recent developments in the surgical pathology of the vulva include updated classifications of non-neoplastic epithelial disorders and vulvar intraepithelial neoplasias. Several histologic variants of vulvar squamous cell carcinoma (SCC) with distinct clinicopathologic features have been described. The concept of super...

journal_title：Clinics in laboratory medicine

authors： Johnson TL

更新日期：1995-09-01 00:00:00

abstract：:ALP is a profoundly ubiquitous enzyme that originates in many, if not all, mammalian tissues. The development of a simple ISEF technique has allowed reflection of at least 12 cellular components. Improvements in technique may add further zones of information. The aura of darkness surrounding ALP is being slowly dissip...

journal_title：Clinics in laboratory medicine

authors： Griffiths J

更新日期：1989-12-01 00:00:00

abstract：:Routine biochemical tests generally include serum enzymes, proteins, and other markers useful for identifying hepatobiliary disease in dogs and cats. Obtaining results outside the reference intervals can occur with direct hepatocellular injury, enzyme induction by hepatocytes or biliary epithelium, or decreased hepati...

journal_title：Clinics in laboratory medicine

authors： Chapman SE,Hostutler RA

更新日期：2015-09-01 00:00:00

abstract：:Immunology testing is relevant for the diagnosis of many autoimmune conditions. However, diagnostic pitfalls arise owing to incorrect interpretation of results and incomplete understanding of the underlying technique or immune-mediated condition. Here, we review the diagnostic considerations related to commonly used i...

journal_title：Clinics in laboratory medicine

authors： Maher L,Perugino C

更新日期：2019-12-01 00:00:00

abstract：:The authors describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months from at least 28 workstations. The application was used to plot...

journal_title：Clinics in laboratory medicine

authors： Benn N,Turlais F,Clark V,Jones M,Clulow S

更新日期：2007-03-01 00:00:00

abstract：:Transgenic mice that contain a proline to leucine mutation at amino acid 101 in the endogenous murine PrP gene have been produced by gene targeting. This line of mice was generated to model the mutation thought to be responsible for P102L GSS, a familial TSE disease in humans. Genetargeted 101LL mice showed no evidenc...

journal_title：Clinics in laboratory medicine

authors： Barron RM,Manson JC

更新日期：2003-03-01 00:00:00

abstract：:Vertical auto profile (VAP) method is a direct single test for measuring comprehensive lipoprotein cholesterol profile. It is based on a well-established method of ultracentrifugation that uses vertical rotor and single density gradient spin. VAP provides cholesterol concentrations of total lipoprotein, high-density l...

journal_title：Clinics in laboratory medicine

authors： Kulkarni KR

更新日期：2006-12-01 00:00:00

abstract：:This second part of the review article compiles currently available information on the effects of lead poisoning. Also examined are the available options for assay, the procedures for collection of samples, and the available methods for the estimation of lead in the collected samples. ...

journal_title：Clinics in laboratory medicine

authors： Philip AT,Gerson B

更新日期：1994-09-01 00:00:00

abstract：:Several major pet-food and human-food safety incidents occurred worldwide between 2003 and 2008, causing illnesses and deaths in children, cats, dogs, and pigs. During the 2007 outbreak of renal failure in dogs and cats in the United States, veterinary diagnostic laboratories helped identify melamine and melamine anal...

journal_title：Clinics in laboratory medicine

authors： Puschner B,Reimschuessel R

更新日期：2011-03-01 00:00:00

abstract：:The use of enzyme histochemical and immunohistochemical markers has improved our understanding of the biology of lymphoproliferative disorders. These same techniques can now provide practical information when applied to the diagnosis of lymphoproliferative disorders. ...

journal_title：Clinics in laboratory medicine

authors： Beckstead JH

更新日期：1988-03-01 00:00:00

abstract：:The clinical diagnosis and management of thyroid hormone excess and deficiency are dependent on accurate laboratory measurements and the interpretation of serum free T4 and TSH values. A variety of free T4 methods are available that perform well in otherwise healthy patients with hypothyroidism or hyperthyroidism and ...

journal_title：Clinics in laboratory medicine

authors： Kaptein EM

更新日期：1993-09-01 00:00:00

abstract：:Image processing has traveled to the lunar surface and back, finding its way into the clinical laboratory. Advances in digital computers have improved the technology of image analysis, resulting in a wide variety of medical applications. Offering improvements in turnaround time, standardized systems, increased precisi...

journal_title：Clinics in laboratory medicine

authors： Kisner HJ

更新日期：1988-12-01 00:00:00

abstract：:Pet guinea pigs are presented to veterinary clinics for routine care and treatment of clinical diseases. In addition to obtaining clinical history and exam findings, diagnostic testing may be required, including hematological assessments. This article describes common blood collection methods, including venipuncture s...

journal_title：Clinics in laboratory medicine

authors： Zimmerman K,Moore DM,Smith SA

更新日期：2015-09-01 00:00:00

abstract：:The combination of requirements for decreased turnaround time for hematology laboratory results and advances in technology have driven testing closer to the point of patient contact. This article provides an overview of the technologies available to measure hemoglobin, white blood cell counts, differentials, and CD4+ ...

journal_title：Clinics in laboratory medicine

authors： Sireci AN

更新日期：2015-03-01 00:00:00

abstract：:With the US Food and Drug Administration's recent label change of warfarin to include genetic testing for warfarin sensitivity, manufacturers are developing assays, and laboratories are offering testing. This article describes the genetic variants for which testing is available. Current technologies and assays are com...

journal_title：Clinics in laboratory medicine

authors： Lyon E,McMillin G,Melis R

更新日期：2008-12-01 00:00:00

abstract：:The subject of this article is privacy and its relationship to the activities of health care organizations. Privacy is a good quality that each individual may possess. The quality of an individual's privacy is a personal determination. Although everyday life requires that we attempt to understand and protect the priva...

journal_title：Clinics in laboratory medicine

authors： Essin DJ

更新日期：1999-06-01 00:00:00

abstract：:This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...

journal_title：Clinics in laboratory medicine

authors： Spring JL,Winkler A,Levy JH

更新日期：2014-09-01 00:00:00

abstract：:Large-scale clinical databases provide a detailed perspective on patient phenotype in disease and the characteristics of health care processes. Important information is often contained in the relationships between the values and timestamps of sequences of clinical data. The analysis of clinical time sequence data acro...

journal_title：Clinics in laboratory medicine

authors： Post AR,Harrison JH Jr

更新日期：2008-03-01 00:00:00

abstract：:Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater...

journal_title：Clinics in laboratory medicine

authors： Mazzella FM,Alvares C,Kowal-Vern A,Schumacher HR

更新日期：2000-03-01 00:00:00

abstract：:With a focus on low-cost and low-power consumption, a miniature laser-induced fluorescence (LIF) detection system was assembled using a 635 nm red diode laser as the excitation source and a photodiode element coupled with an operational amplifier for signal collection. The primary elements of the miniature system, nam...

journal_title：Clinics in laboratory medicine

authors： Shrinivasan S,Norris PM,Landers JP,Ferrance JP

更新日期：2007-03-01 00:00:00

abstract：:The optimal care of septic patients depends on the successful recovery of clinically relevant microorganisms from blood cultures and the timely reporting of organism identification and antimicrobial susceptibility testing (AST) results. Many preanalytic factors play a critical role in culturing microorganisms, and adv...

journal_title：Clinics in laboratory medicine

authors： Gonzalez MD,Chao T,Pettengill MA

更新日期：2020-12-01 00:00:00

abstract：:With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive mi...

journal_title：Clinics in laboratory medicine

authors： Smith KP,Kirby JE

更新日期：2019-09-01 00:00:00

abstract：:Acute accidental iron poisoning is a common serious and potentially fatal intoxication in the young child. Approximately 1 per cent of such poisoning have a fatal outcome, and outcome is closely related to the early onset of coma or shock. Long-term prognosis is excellent for all survivors of the acute episode, althou...

journal_title：Clinics in laboratory medicine

authors： Henretig FM,Temple AR

更新日期：1984-09-01 00:00:00

abstract：:Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...

journal_title：Clinics in laboratory medicine

authors： Mulley AG

更新日期：1986-06-01 00:00:00

abstract：:The development and adaptation of synthetic substrates has introduced new concepts and methodologies to the coagulation laboratory. Synthetic substrates offer potentially improved standardization over conventional testing, providing a rapid, sensitive, and specific way to measure enzymes directly. ...

journal_title：Clinics in laboratory medicine

authors： Musgrave KA,Triplett DA

更新日期：1984-06-01 00:00:00

abstract：:Laboratory informatics is the application of computers and information systems to information management in the pathology laboratory. Effective information management is crucial to the success of pathologists and laboratorians. Informatics has become one of the key pillars of pathology, and the requirement for skilled...

journal_title：Clinics in laboratory medicine

authors： Pantanowitz L,Henricks WH,Beckwith BA

更新日期：2007-12-01 00:00:00

abstract：:"Bath salts" has attracted young adults primarily due to its stimulatory and hallucinogenic effects akin to amphetamines and cocaine. Although other designer amines have been incorporated to newer generation "bath salts", synthetic cathinones remain to be their major component. This article discusses our current under...

journal_title：Clinics in laboratory medicine

authors： Gerona RR,Wu AH

更新日期：2012-09-01 00:00:00