Molecular diagnostics in the neoplasms of small intestine and appendix.

Abstract:

:Adenocarcinoma of the small intestine is relatively rare in comparison to colorectal carcinoma. Adenocarcinoma of the small intestine arises through the adenoma-carcinoma sequence in the colon. However, adenocarcinomas arising in the background of inflammatory bowel disease develop through the dysplasia-carcinoma sequence. Most of the cases occur in the duodenum; however, adenocarcinoma occurring in association with Crohn disease is more common in the ileum.

journal_name

Clin Lab Med

authors

Bhalla A,Zulfiqar M,Weindel M,Shidham VB

doi

10.1016/j.cll.2013.08.007

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

861-6

issue

4

eissn

0272-2712

issn

1557-9832

pii

S0272-2712(13)00070-X

journal_volume

33

pub_type

杂志文章,评审
  • Breast Cancer in Low- and Middle-Income Countries: Why We Need Pathology Capability to Solve This Challenge.

    abstract::Breast cancer is the leading cause of cancer mortality among women in developing countries. Timely and accurate histopathological diagnosis of breast cancer is critical to delivering high-quality breast cancer care to patients in low- and middle-income countries (LMIC). The most important prognostic factors in breast ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2017.10.013

    authors: Martei YM,Pace LE,Brock JE,Shulman LN

    更新日期:2018-03-01 00:00:00

  • Malpractice in dermatopathology: principles, risk mitigation, and opportunities for improved care for the histologic diagnosis of melanoma and pigmented lesions.

    abstract::Melanoma represents a substantial source of risk within dermatology and dermatopathology. This article seeks to provide general pathologists, dermatologists and dermatopathologists with an overview of the basics principles of medical malpractice litigation, a review of the essentials of reporting and the importance of...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2007.12.006

    authors: High WA

    更新日期:2008-06-01 00:00:00

  • A low-cost, low-power consumption, miniature laser-induced fluorescence system for DNA detection on a microfluidic device.

    abstract::With a focus on low-cost and low-power consumption, a miniature laser-induced fluorescence (LIF) detection system was assembled using a 635 nm red diode laser as the excitation source and a photodiode element coupled with an operational amplifier for signal collection. The primary elements of the miniature system, nam...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2006.12.010

    authors: Shrinivasan S,Norris PM,Landers JP,Ferrance JP

    更新日期:2007-03-01 00:00:00

  • Coagulopathies of liver disease.

    abstract::Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Mammen EF

    更新日期:1994-12-01 00:00:00

  • Laboratory aspects of prenatal microarray analysis.

    abstract::The recent development and clinical implementation of genomic microarrays has resulted in rapid and significant changes for postnatal studies in the field of cytogenetics. This article discusses the benefits and issues for the use of microarrays for prenatal genetic diagnosis. It includes sections on specimen processi...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2011.08.004

    authors: Lamb AN

    更新日期:2011-12-01 00:00:00

  • Modifying Risk of Aneuploidy with a Positive Cell-Free Fetal DNA Result.

    abstract::Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental troph...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.01.018

    authors: Long AA,Abuhamad AZ,Warsof SL

    更新日期:2016-06-01 00:00:00

  • Current assessment of microhematuria and leukocyturia.

    abstract::Technical advances in laboratory testing such as sensitive chemical tests and standardized commercial slides have significantly altered our entire approach to urinalysis. In addition, the recognition of the association of microhematuria with urologic neoplasms and the morphologically altered red blood cells with renal...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Shenoy UA

    更新日期:1985-06-01 00:00:00

  • Future of molecular testing for red blood cell antigens.

    abstract::When one looks at the field of molecular pathology or transplantation, it is evident that molecular biology has made a positive impact on medicine. However, the progress in transfusion medicine has been slower and more cautious than in other areas of the clinical laboratory. To understand where the field may go in the...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2010.02.004

    authors: Moulds JM

    更新日期:2010-06-01 00:00:00

  • Monoclonal antibodies for bacterial identification and taxonomy: 1985 and beyond.

    abstract::Contemporary bacterial serology relevant to medicine involves poly- and monoclonal antibodies to study pathogenic bacteria and nonpathogenic organisms useful in controlling infectious diseases. Monoclonal antibody applications include immunodiagnostics, prophylaxis and serotherapy, and microbial biotechnology and mole...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Conway de Macario E,Macario AJ

    更新日期:1985-09-01 00:00:00

  • Tumor markers in endocrine malignancies.

    abstract::The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: DeLellis RA

    更新日期:1990-03-01 00:00:00

  • Diagnostic utility of red cell flow cytometric analysis.

    abstract::Although most of the diagnostic applications of flow cytometry bring forth examples of leukocyte immunophenotyping for immunodeficiency diseases and leukemia-lymphoma diagnosis, the same technology has improved medical assessment of diseases affecting the red cell and erythropoiesis. Flow cytometric methods were first...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Davis BH

    更新日期:2001-12-01 00:00:00

  • Prenatal screening for open neural tube defects.

    abstract::The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/s0272-2712(03)00032-5

    authors: Canick JA,Kellner LH,Bombard AT

    更新日期:2003-06-01 00:00:00

  • Diagnosis and management of neonatal alloimmune thrombocytopenia in pregnancy.

    abstract::Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in the healthy newborn, occurring in 1 in 1000 live births. NAIT is analogous to rhesus alloimmunization in pathophysiology; however, it often presents unexpectedly in first pregnancies. Presentation of NAIT varies from mil...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2013.03.024

    authors: Strong NK,Eddleman KA

    更新日期:2013-06-01 00:00:00

  • Metrological Traceability of Assays and Comparability of Patient Test Results.

    abstract::At the start of the twenty-first century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be formally applied to clinical laboratory field methods, resulting in a new appreciation of metrological calibrator traceability. It is a change beca...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2016.09.010

    authors: Armbruster D

    更新日期:2017-03-01 00:00:00

  • Patterns of injury. Blunt and sharp.

    abstract::The pathologist, by virtue of his or her observations and documentation of injuries with concomitant attempts to discern patterns of injury and correlate autopsy findings with investigative details, will often play an integral and primary role in the death investigation process. The information gleaned during this pro...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Davis GJ

    更新日期:1998-06-01 00:00:00

  • Point-of-care testing. An overview and a look to the future.

    abstract::Point-of-care testing is an emerging specialty in laboratory medicine and has attracted considerable interest in the medical literature. This article presents a general overview of point-of-care testing including its history, menu, clinical utility, aspects of analytical performance, regulatory issues, and management ...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Lee-Lewandrowski E,Lewandrowski K

    更新日期:2001-06-01 00:00:00

  • Spectrum of ischemic heart disease and the role of biochemical markers.

    abstract::An exciting era exists as a result of the introduction of novel markers of myocardial damage. The prognostic implications of troponins, even in the setting of "minor myocardial damage," are potentially of immense value to patient care. We need to take the next step and assess the outcomes of interventions in these set...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Tymchak WJ,Armstrong PW

    更新日期:1997-12-01 00:00:00

  • Fine-needle aspiration cytology of the ovary.

    abstract::FNA cytology has been shown to be highly accurate in diagnosing malignant tumors. In gynecology, an overall accuracy of 94.5% in the differentiation between benign and malignant tumors has been reported. Despite many controversial views regarding its safety, aspiration cytology has been accepted as an innocuous proced...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Ganjei P

    更新日期:1995-09-01 00:00:00

  • Laboratory diagnosis of antiphospholipid syndromes.

    abstract::The search for clinical outcomes associated with antiphospholipid antibodies (aPL) has been ongoing for a decade. This article focuses on the clinical use of tests for the detection of aPL. A review of the current thinking regarding the pathophysiology of antiphospholipid syndromes is relevant to the discussion of dif...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Reyes H,Dearing L,Bick RL,Shoenfeld Y,Peter JB

    更新日期:1995-03-01 00:00:00

  • Antimicrobic susceptibility testing. A personal perspective.

    abstract::The development of antimicrobic susceptibility testing is outlined with particular reference to standardization of procedures and organizational developments that have led to substantially improved performance. Special problems continue to be posed by increased proportions of opportunistic pathogens and newly recogniz...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Sherris JC

    更新日期:1989-06-01 00:00:00

  • Point-of-care testing for disasters: needs assessment, strategic planning, and future design.

    abstract::Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:10.1016/j.cll.2009.07.014

    authors: Kost GJ,Hale KN,Brock TK,Louie RF,Gentile NL,Kitano TK,Tran NK

    更新日期:2009-09-01 00:00:00

  • Managing physician use of laboratory tests.

    abstract::The active management of laboratory test utilization appears to be a practical approach to addressing the financial pressures imposed by managed care and capitated reimbursement, and can complement efforts already underway in most laboratories to reduce the unit cost of testing. Managing laboratory utilization takes t...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Valenstein P

    更新日期:1996-09-01 00:00:00

  • Pharmacogenetic testing for warfarin sensitivity.

    abstract::With the US Food and Drug Administration's recent label change of warfarin to include genetic testing for warfarin sensitivity, manufacturers are developing assays, and laboratories are offering testing. This article describes the genetic variants for which testing is available. Current technologies and assays are com...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2008.09.001

    authors: Lyon E,McMillin G,Melis R

    更新日期:2008-12-01 00:00:00

  • Yellow fever: a reemerging threat.

    abstract::Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas, which principally affects humans and nonhuman primates and is transmitted via the bite of infected mosquitoes. Yellow fever virus (YFV) can cause devastating epidemics of potentially fatal, hemorrhagic disease. Despite mass v...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2010.01.001

    authors: Gardner CL,Ryman KD

    更新日期:2010-03-01 00:00:00

  • Timing of repeated monitoring tests.

    abstract::This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Eddy DM

    更新日期:1982-12-01 00:00:00

  • Laboratory computers: tools for increased productivity.

    abstract::Revolutionary changes in the computer industry brought about in part by the introduction of personal computers are now reaching into clinical laboratories everywhere. Although the true justification for any computer tool may be an intangible one such as improvement in service, such tools can typically be cost justifie...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hendricks EJ

    更新日期:1985-12-01 00:00:00

  • Should we do another test? Decision making in blood banking.

    abstract::A decision model was developed to evaluate the costs and benefits of further reducing the risk of transfusion-transmitted disease. The model addresses recipient risk factors as well as operational considerations. Application of the model to prior risk reduction decisions documents its validity as a decision-making too...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章

    doi:

    authors: Hanson M

    更新日期:1996-12-01 00:00:00

  • A molecular view of the neurologic porphyrias.

    abstract::At the present time, the use of molecular techniques for diagnosing the neurologic porphyrias is limited mainly to those laboratories doing research in the area. Because any of four genes may be involved, it is important to confirm the diagnosis in the index case before undertaking molecular investigation. With advanc...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: Schreiber WE

    更新日期:1997-03-01 00:00:00

  • Quality control in the blood bank.

    abstract::In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:

    authors: White KK,Silberstein LE

    更新日期:1986-12-01 00:00:00

  • Current controversies in testosterone testing: aging and obesity.

    abstract::The interpretation of the total serum testosterone concentration is problematic because it is related directly to the serum SHBG concentration.Frequently, an estimate of the serum free testosterone concentration is obtained to better assess the clinical status of the patient. We reviewed five methods for the determina...

    journal_title:Clinics in laboratory medicine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cll.2004.01.010

    authors: Elin RJ,Winters SJ

    更新日期:2004-03-01 00:00:00