Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions.

abstract：:The last decade has witnessed the transformation of first-trimester Down syndrome screening from an aspiration to a clinical reality. First-trimester screening now equals or exceeds the diagnostic accuracy of conventional midtrimester screen while realizing an important desire of pregnant women for early diagnosis. Be...

journal_title：Clinics in laboratory medicine

authors： Bahado-Singh RO,Argoti P

更新日期：2010-09-01 00:00:00

abstract：:The pathologist, by virtue of his or her observations and documentation of injuries with concomitant attempts to discern patterns of injury and correlate autopsy findings with investigative details, will often play an integral and primary role in the death investigation process. The information gleaned during this pro...

journal_title：Clinics in laboratory medicine

authors： Davis GJ

更新日期：1998-06-01 00:00:00

abstract：:Recent developments in the surgical pathology of the vulva include updated classifications of non-neoplastic epithelial disorders and vulvar intraepithelial neoplasias. Several histologic variants of vulvar squamous cell carcinoma (SCC) with distinct clinicopathologic features have been described. The concept of super...

journal_title：Clinics in laboratory medicine

authors： Johnson TL

更新日期：1995-09-01 00:00:00

abstract：:This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...

journal_title：Clinics in laboratory medicine

authors： Spring JL,Winkler A,Levy JH

更新日期：2014-09-01 00:00:00

abstract：:At the start of the twenty-first century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be formally applied to clinical laboratory field methods, resulting in a new appreciation of metrological calibrator traceability. It is a change beca...

journal_title：Clinics in laboratory medicine

authors： Armbruster D

更新日期：2017-03-01 00:00:00

abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...

journal_title：Clinics in laboratory medicine

authors： Laughlin MA,Pomerantz RJ

更新日期：1994-06-01 00:00:00

abstract：:Molecular biological techniques have evolved expeditiously and in turn have been applied to the detection of infectious disease. Maturation of these technologies and their coupling with related technological advancement in fluorescence, electronics, digitization, nanodynamics, and sensors among others have afforded cl...

journal_title：Clinics in laboratory medicine

authors： Fairfax MR,Bluth MH,Salimnia H

更新日期：2018-06-01 00:00:00

abstract：:An obvious advantage of a combined PAP and PSA measurement is the increased sensitivity of detection. Furthermore, the use of both markers in monitoring patients with prostatic carcinoma offers the advantage of a greater number of patients with objective parameters for follow-up. ...

journal_title：Clinics in laboratory medicine

authors： Saito Y

更新日期：1993-03-01 00:00:00

abstract：:The mean platelet volume measurement can reflect changes in either the level of platelet stimulation or rate of platelet production. The controversy related to whether platelets change volume or density in the circulation is still not clearly resolved, and although the relationship between platelet number and size and...

journal_title：Clinics in laboratory medicine

authors： Threatte GA

更新日期：1993-12-01 00:00:00

abstract：:The current success in organ transplantation has been brought about by immunosuppressive therapy. Improvements in transplant outcome using these drugs have stalled, and an understanding of the pharmacogenomics of immunosuppressive dosing and response holds the greatest promise for advancing the use of these agents. ...

journal_title：Clinics in laboratory medicine

authors： Burckart GJ

更新日期：2008-09-01 00:00:00

abstract：:Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory resp...

journal_title：Clinics in laboratory medicine

authors： Ryan US,Ryan JW

更新日期：1983-12-01 00:00:00

abstract：:Cyclosporine (CsA) monitoring has remained controversial since the advent of the use of CsA in organ transplantation in the early 1980s. This article attempts to clarify for the clinical laboratory worker many of the vagaries associated with CsA monitoring by considering choice of sample matrix, the nature of metaboli...

journal_title：Clinics in laboratory medicine

authors： Napoli KL,Kahan BD

更新日期：1991-09-01 00:00:00

abstract：:Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems re...

journal_title：Clinics in laboratory medicine

authors： Rusyniak DE,Sprague JE

更新日期：2006-03-01 00:00:00

abstract：:Neonatal alloimmune thrombocytopenia (NAIT) is the most common cause of severe thrombocytopenia in the healthy newborn, occurring in 1 in 1000 live births. NAIT is analogous to rhesus alloimmunization in pathophysiology; however, it often presents unexpectedly in first pregnancies. Presentation of NAIT varies from mil...

journal_title：Clinics in laboratory medicine

authors： Strong NK,Eddleman KA

更新日期：2013-06-01 00:00:00

abstract：:"Bath salts" has attracted young adults primarily due to its stimulatory and hallucinogenic effects akin to amphetamines and cocaine. Although other designer amines have been incorporated to newer generation "bath salts", synthetic cathinones remain to be their major component. This article discusses our current under...

journal_title：Clinics in laboratory medicine

authors： Gerona RR,Wu AH

更新日期：2012-09-01 00:00:00

abstract：:The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...

journal_title：Clinics in laboratory medicine

authors： Canick JA,Kellner LH,Bombard AT

更新日期：2003-06-01 00:00:00

abstract：:Immunology testing is relevant for the diagnosis of many autoimmune conditions. However, diagnostic pitfalls arise owing to incorrect interpretation of results and incomplete understanding of the underlying technique or immune-mediated condition. Here, we review the diagnostic considerations related to commonly used i...

journal_title：Clinics in laboratory medicine

authors： Maher L,Perugino C

更新日期：2019-12-01 00:00:00

abstract：:Diabetes mellitus affects almost 16 million Americans. It has become a major public health problem and the number one cause of adult blindness, end-stage renal disease, and nontraumatic amputations in the United States. It also markedly increases the risk for cardiovascular, cerebrovascular, and peripheral artery dise...

journal_title：Clinics in laboratory medicine

authors： Kazi AA,Blonde L

更新日期：2001-03-01 00:00:00

abstract：:Antiretroviral failure caused by the development of drug resistance in HIV-1 is an increasingly common clinical problem. Two types of resistance assays are available to clinicians. Genotypic assays determine the presence of mutations associated with drug resistance. The interpretation of mutations is often complicated...

journal_title：Clinics in laboratory medicine

authors： Hanna GJ

更新日期：2002-09-01 00:00:00

abstract：:The interpretation of the total serum testosterone concentration is problematic because it is related directly to the serum SHBG concentration.Frequently, an estimate of the serum free testosterone concentration is obtained to better assess the clinical status of the patient. We reviewed five methods for the determina...

journal_title：Clinics in laboratory medicine

authors： Elin RJ,Winters SJ

更新日期：2004-03-01 00:00:00

abstract：:Chromosome analysis is the genetic technique useful in evaluating endocrine disease. Indications for cytogenetic studies include suspected sex chromosomal aneuploidies as well as repeated fetal wastage. In patients with ambiguous genitalia, cytogenetic studies are mandatory, not only to provide information for assigni...

journal_title：Clinics in laboratory medicine

authors： Gordon LP

更新日期：1984-12-01 00:00:00

abstract：:The authors describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months from at least 28 workstations. The application was used to plot...

journal_title：Clinics in laboratory medicine

authors： Benn N,Turlais F,Clark V,Jones M,Clulow S

更新日期：2007-03-01 00:00:00

abstract：:Control of human immunodeficiency virus type-1 (HIV-1) infection is the foremost public health challenge at the turn of the millennium. Two decades, 22 million fatalities, and 40 million living victims after its discovery, HIV-1 continues its inexorable spread. Over the past few years, scientists have made tremendous ...

journal_title：Clinics in laboratory medicine

authors： Elizaga ML,McElrath MJ

更新日期：2002-12-01 00:00:00

abstract：:Diseases due to nontuberculous mycobacteria are increasing in frequency, especially in patients with compromised immunity. A number of "new" mycobacterial species have been described in the last decade, largely as the result of the use of new tools to identify previously unrecognized mycobacteria found in the environm...

journal_title：Clinics in laboratory medicine

authors： Herdman AV,Steele JC Jr

更新日期：2004-09-01 00:00:00

abstract：:A methodology for computing the maximum expected number of unreliable patient results produced because of an out-of-control condition for a given quality control strategy is presented along with strategies for changing the expected number of unreliable results produced and reported. The expected number of unreliable p...

journal_title：Clinics in laboratory medicine

authors： Yundt-Pacheco J,Parvin CA

更新日期：2013-03-01 00:00:00

abstract：:This article attempts to define and identify sources of variation in laboratory analysis that occur predominantly "away" from the analytic bench. Problems in the derivation and application of reference ranges are reviewed and sources of non-analytic error are "located" within the entire testing cycle. Reference source...

journal_title：Clinics in laboratory medicine

authors： Bachner P

更新日期：1986-12-01 00:00:00

abstract：:Disease prevention requires sociopolitical change, which in turn requires the participation of those for whom the change is intended, including demographic groups at high risk for disease, appropriate governmental authorities, and essential health care personnel. Multiparous women of lowest socioeconomic status, the d...

journal_title：Clinics in laboratory medicine

authors： Suba EJ

更新日期：2004-12-01 00:00:00

abstract：:The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production...

journal_title：Clinics in laboratory medicine

authors： Clough JD,Calabrese LH,Budervic SA

更新日期：1988-06-01 00:00:00

abstract：:The most efficacious and practical means of diagnosing human schistosomiasis is based on the detection of infection-specific antibodies. Because of their high sensitivity, antibody assays remain the most practical assays for epidemiologic studies and patient management. Initial screening may be performed in the field ...

journal_title：Clinics in laboratory medicine

authors： Tsang VC,Wilkins PP

更新日期：1991-12-01 00:00:00

abstract：:I have reviewed many of the methods available for the assessment of fetal lung maturity. The difficulty of using diagnostic tests for diseases of low prevalence has been discussed. By reviewing the nature of the amniotic fluid surfactant material, and some of the principles underlying analytical methods, the bases of ...

journal_title：Clinics in laboratory medicine

authors： Dubin SB

更新日期：1992-09-01 00:00:00