Abstract：
:Direct-to-consumer genetic testing came on the scene 2 decades ago as a means for allowing consumers to access their genetic information without the involvement of a physician or genetic counselor. Results are delivered directly to the consumer, often leading to misinterpretation and needless medical interventions or false reassurance. Increasingly, we are seeing these patients in our genetics clinics for test interpretation, management guidance and confirmatory genetic testing.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Dinulos MBP,Vallee SEdoi
10.1016/j.cll.2019.11.003subject
Has Abstractpub_date
2020-03-01 00:00:00pages
61-67issue
1eissn
0272-2712issn
1557-9832pii
S0272-2712(19)30086-1journal_volume
40pub_type
杂志文章,评审abstract：:It is necessary to determine the safety of polymeric materials through laboratory and animal testing before biomedical use can become more widespread. This article describes many of the methods used in analyzing the toxicology and biocompatibility of potentially important biomedical polymers. The study method used in ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1990-09-01 00:00:00
abstract：:Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:Routine biochemical tests generally include serum enzymes, proteins, and other markers useful for identifying hepatobiliary disease in dogs and cats. Obtaining results outside the reference intervals can occur with direct hepatocellular injury, enzyme induction by hepatocytes or biliary epithelium, or decreased hepati...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2015.05.002
更新日期：2015-09-01 00:00:00
abstract：:The category of provider-performed microscopy was defined in the Federal Register to provide a unique regulatory approach for bright-field and phase-contrast microscopy performed by a physician, dentist, or midlevel practitioner examining labile specimens. A CLIA certificate for this category of testing is available, ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：2001-06-01 00:00:00
abstract：:In marked contrast to their historical classification as relatively harmless, common cold-causing, respiratory pathogens, human coronaviruses (HCoVs) are associated with more severe clinical complications, as emphasized by the discovery of severe acute respiratory syndrome-associated CoV (SARS-CoV) in 2003. Still, the...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2009.07.007
更新日期：2009-12-01 00:00:00
abstract：:To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonogr...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2009.02.001
更新日期：2009-03-01 00:00:00
abstract：:The improvement of quality in clinical care can greatly benefit form continuous benchmarking with information based on laboratory data. To be most effective, the information is best provided in the form of real-time disease management decision support. Such an approach requires advances in the implementation of hospit...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1999-12-01 00:00:00
abstract：:Considerable advances have been made in identifying women whose pregnancies are at the greatest risk for fetal Down syndrome and other aneuploidies. Maternal serum tests and ultrasonography in either the first or second trimester provide effective prenatal screening. However, the most efficacious protocols are based o...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2010.04.013
更新日期：2010-09-01 00:00:00
abstract：:The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0272-2712(03)00032-5
更新日期：2003-06-01 00:00:00
abstract：:The interpretation of the total serum testosterone concentration is problematic because it is related directly to the serum SHBG concentration.Frequently, an estimate of the serum free testosterone concentration is obtained to better assess the clinical status of the patient. We reviewed five methods for the determina...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2004.01.010
更新日期：2004-03-01 00:00:00
abstract：:Modern advances in the diagnosis and treatment of the leukemias and lymphomas make use of dynamic techniques in immunology, genetics, and molecular biology, and, as a result, morphology represents a smaller proportion of the total diagnostic work-up of these diseases today than heretofore. However, morphology still re...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:The clinical application of B- and T-cell gene rearrangement analysis is discussed relative to diagnostic problems in specific lymphoproliferative disorders. This article reviews the use of the Southern blot hybridization technique for B- and T-cell gene rearrangement detection in the analysis of various hematopoietic...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Nephroblastoma, or Wilms tumor, is a malignant embryonal neoplasm that is derived from nephrogenic blastemal cells, with variable recapitulation of renal embryogenesis. The pathogenesis of nephroblastoma is complex and has been linked to alterations of several genomic loci, including WT1, WT2, FWT1, and FWT2. Generall...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2005.01.010
更新日期：2005-06-01 00:00:00
abstract：:As aerobic creatures, normal living requires that not only are human beings exposed to oxygen but are dependent on oxygen. Humans have evolved mechanisms to cope with living in an aerobic environment; however, modern humans may be more exposed to oxidant stresses. Much indirect evidence implicates reactive oxygen spec...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
abstract：:Simple, inexpensive procedures for rapid identification of the common bacterial pathogens are outlined in detail. When the tests are judiciously applied, most isolates can be identified within minutes or hours, and strains that require more extensive testing for accurate identification will be recognized. ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1985-03-01 00:00:00
abstract：:India is a global leader in diabetes, currently with second largest pool of diabetes in the world. Asian Indian phenotype is uniquely predisposed to develop type 2 diabetes because of strong familial aggregation as well lifestyle factors of imprudent diet and sedentary physical habit. The typical Asian Indian phenotyp...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2012.04.012
更新日期：2012-06-01 00:00:00
abstract：:A rapidly increasing body of evidence links human papillomavirus (HPV) to cervical neoplasia through epidemiologic associations, pathologic features, molecular detection, and mechanisms of oncogenesis. HPV is now accepted as the primary cause of cervical neoplasia and accounts for most of the risk factors traditionall...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：:This article reviews congenital melanocytic nevi (CMN), which are present at birth or appear shortly thereafter, and their main histologic features. Several histologic variants and histopathologic criteria that differentiate CMN from other nevi, such as atypical or dysplastic nevi, and from nevoid malignant melanoma, ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2011.03.004
更新日期：2011-06-01 00:00:00
abstract：:During the past 20 years, laboratory systems have evolved to a high degree of complexity. In some cases, continuing addition of new features has adversely affected functionality. There is increasing recognition that the number of features listed on a request for proposal does not necessarily provide an accurate guide ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1991-03-01 00:00:00
abstract：:Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided in...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2018.08.002
更新日期：2018-12-01 00:00:00
abstract：:The search for clinical outcomes associated with antiphospholipid antibodies (aPL) has been ongoing for a decade. This article focuses on the clinical use of tests for the detection of aPL. A review of the current thinking regarding the pathophysiology of antiphospholipid syndromes is relevant to the discussion of dif...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:Large-scale clinical databases provide a detailed perspective on patient phenotype in disease and the characteristics of health care processes. Important information is often contained in the relationships between the values and timestamps of sequences of clinical data. The analysis of clinical time sequence data acro...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：10.1016/j.cll.2007.10.005
更新日期：2008-03-01 00:00:00
abstract：:Antiretroviral failure caused by the development of drug resistance in HIV-1 is an increasingly common clinical problem. Two types of resistance assays are available to clinicians. Genotypic assays determine the presence of mutations associated with drug resistance. The interpretation of mutations is often complicated...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0272-2712(02)00007-0
更新日期：2002-09-01 00:00:00
abstract：:Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological un...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2016.05.004
更新日期：2016-09-01 00:00:00
abstract：:An ideal immunohistochemical screening panel would be one in which each antibody is 100% sensitive and specific for the target cell type (e.g., markers for epithelial neoplasms, lymphomas, sarcomas, etc.). Anyone who has practiced immunochemistry is well aware that this situation does not exist. High sensitivity is hi...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1990-03-01 00:00:00
abstract：:From the inception of TBS in 1988, it has been well received by the pathology and clinical communities. The need for a unifying system of nomenclature was so great that most of the laboratories in the United States, as well as in numerous countries worldwide, quickly adopted TBS. By 1991, only 2 years after the initia...
journal_title：Clinics in laboratory medicine
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/s0272-2712(03)00053-2
更新日期：2003-09-01 00:00:00
abstract：:Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2015.07.006
更新日期：2015-12-01 00:00:00
abstract：:To date, CRP remains the single standard biochemical marker for predicting the severity of AP. Because the combination of clinico-physiological scores and CRP provides good information at 48 hours, research has focused on the predictive ability of various markers when applied in the initial 24 hours after admission to...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2004.12.003
更新日期：2005-03-01 00:00:00
abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:The clinical diagnosis and management of thyroid hormone excess and deficiency are dependent on accurate laboratory measurements and the interpretation of serum free T4 and TSH values. A variety of free T4 methods are available that perform well in otherwise healthy patients with hypothyroidism or hyperthyroidism and ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1993-09-01 00:00:00
