Abstract:
PURPOSE:To evaluate the efficacy, effect profile, and safety of dexamethasone implant on diabetic macular edema (DME) in a real-life setting, further comparing results by DME duration, previous treatment status, and diabetic control. DESIGN:A multicenter, retrospective cohort of 340 DME eyes of 287 patients from 25 clinical sites from 8 countries. METHODS:Data were analyzed in 2 perspectives: per injection, in which all measurements were grouped and baseline was defined as the day of injection, and thus the pharmacodynamics of single injections could be assessed; and injection series, defined as 2 or more injections with 3 to 6 months between injections analyzing the outcome 3 to 6 months after the last injection. MAIN OUTCOME MEASURES:Primary outcome was improvement of 15 or more letters in best-corrected visual acuity (BCVA) from baseline. Secondary outcomes included improvement of 10 letters or more in BCVA, change in central macular thickness (CMT), and time to maximum improvement and safety. RESULTS:Overall, 762 injections were administered to 340 eyes of 287 patients. Injection series analysis included 171 series in 171 eyes of 150 patients, for a total of 444 injections, with a mean follow-up of 1.7±0.8 years. Of the 762 injections analyzed per injection, 22.7% achieved a 15-letter or more improvement, and 37.8% achieved a 10-letter or more improvement. Mean time to peak improvement was 81.9±39.7 days. Mean maximum change in CMT was -174±171 μm. Overall, 7.6% lost 15 or more letters. More eyes with early DME gained 10 or more letters and fewer eyes lost 10 or more letters compared with eyes with late DME (47.4% vs. 33.9% [P = 0.001] and 8.2% vs. 13.5% [P = 0.029], respectively). Patients with controlled diabetes showed greater CMT reduction (P = 0.0002). A higher percentage of treatment-naive patients gained 10 or 15 letter or more in BCVA (P = 0.001 and P = 0.006, respectively). Intraocular pressure elevation of more than 25 mmHg was found following 7.9% of injections; no endophthalmitis was reported. CONCLUSIONS:Dexamethasone implant is an effective and safe treatment for DME. Peak improvement was achieved 3 months after injection and dissipated thereafter. Clinicians and providers may consider shortening treatment intervals.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Rosenblatt A,Udaondo P,Cunha-Vaz J,Sivaprasad S,Bandello F,Lanzetta P,Kodjikian L,Goldstein M,Habot-Wilner Z,Loewenstein A,ARTES Study Group.doi
10.1016/j.ophtha.2019.10.005subject
Has Abstractpub_date
2020-03-01 00:00:00pages
377-393issue
3eissn
0161-6420issn
1549-4713pii
S0161-6420(19)32112-8journal_volume
127pub_type
杂志文章,多中心研究相关文献
OPHTHALMOLOGY文献大全abstract::Evaluation of 200 consecutive pars plana vitrectomies shows delayed corneal epithelial healing after intentional scraping and formation of a posterior subcapsular cataract, presumably due to exposure to inadequate infusion fluids. Posterior retinal holes occur frequently, whereas entrance site complications have been ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(78)35684-0
更新日期:1978-02-01 00:00:00
abstract:OBJECTIVE:To identify any mutation of the UbiA prenyltransferase domain-containing protein 1 (UBIAD1) gene in Japanese patients with Schnyder's crystalline corneal dystrophy (SCCD) and to investigate in vivo microstructural phenotype and genotype correlations using laser scanning confocal microscopy (Heidelberg Retina ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2008.12.042
更新日期:2009-06-01 00:00:00
abstract:PURPOSE:To examine whether glaucoma status or measures of visual function affected by glaucoma are associated with self-reported difficulty with vision-intensive tasks in a population-based study. DESIGN:Cross-sectional study. PARTICIPANTS:One thousand one hundred sixty individuals who participated in the fourth roun...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.04.050
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:To determine when posterior vitreous detachments (PVDs) develop after phacoemulsification and aspiration combined with foldable intraocular lens implantation. DESIGN:Prospective, consecutive case series. PARTICIPANTS:A total of 575 eyes without a PVD preoperatively were studied prospectively and followed for ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2012.03.050
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:To evaluate the short-term and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma. DESIGN:Prospective study. PARTICIPANTS:Twenty-two patients previously implanted with a sulcus-based IOP sensor (EyeMate, Implandata GmbH, Germany). METHODS:Twenty-two patients previous...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2020.07.016
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:To assess associations between health-related quality of life (HRQOL) and the decision to perform strabismus surgery for children with intermittent exotropia. DESIGN:Retrospective chart review. PARTICIPANTS:Children with intermittent exotropia. METHODS:Included subjects, identified in a clinical practice, ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2013.10.029
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:To investigate the anatomic relation between the optic nerve and the adjacent intracranial internal carotid artery (ICA) in patients with unexplained optic neuropathy. METHODS:Coronal magnetic resonance images (MRIs) of 20 patients with unexplained optic neuropathy and 20 age-matched controls were evaluated wi...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(96)30664-7
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN:Two case reports. PARTIC...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/S0161-6420(99)00723-X
更新日期:1999-07-01 00:00:00
abstract::Hydrogel keratophakia is a new form of lamellar refractive surgery which, in theory, can deal with almost all forms of refractive error. We examined the histopathological effects of several types of hydrogel materials on the cornea of non-human primates. With the exception of one type of hydrogel material, which was a...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33869-1
更新日期:1985-09-01 00:00:00
abstract::Perfluoropropane (C3F8) was injected into nine eyes of six cynomolgus monkeys. In all nine eyes, macular changes consistent with the development of a macular cyst were noted within 3 months after injection. On fluorescein angiography, there was no evidence of retinal vascular leakage associated with the macular cysts....
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(91)32259-0
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population. DESIGN:Retrospective medical records review. PARTICIPANTS:Fifteen- to 64-year-olds with microbial keratitis treated at the Royal Victorian Eye and Ear Hospital betwee...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.08.013
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To investigate the distribution of the eye's higher-order aberrations in postoperative laser refractive surgery patients with visual complaints and highly irregular corneal shapes. DESIGN:Retrospective case-control study. PARTICIPANTS:Thirty-three symptomatic postoperative LASIK and/or photorefractive keratec...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2005.04.022
更新日期:2005-10-01 00:00:00
abstract:PURPOSE:To detect changes in the compliance and baseline position (position at the baseline time point of a compliance test) of the monkey optic disc after the onset of chronic experimental glaucoma. METHODS:Sixty-six compliance tests were performed on 26 eyes of 13 monkeys. Longitudinal Study. In seven normal monkeys...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(95)30791-9
更新日期:1995-12-01 00:00:00
abstract::One hundred and sixty-two patients with presumed ocular histoplasmosis syndrome were evaluated. New macular scars not present on initial angiogram developed in 9% of eyes. The risk of developing a symptomatic macular lesion in eyes with asymptomatic macular scars was 23%. In eyes with peripapillary scarring, 3.8% deve...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(80)35226-3
更新日期:1980-05-01 00:00:00
abstract:PURPOSE:Previous approaches using deep learning (DL) algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative spectral-domain (SD) OCT data to train a DL algorithm to quantify glauco...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2018.12.033
更新日期:2019-04-01 00:00:00
abstract:PURPOSE:The authors determine if specific features of the clinical presentation of acute postoperative endophthalmitis correlated with the microbiologic culture results. METHODS:A total of 420 patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens impl...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0161-6420(97)30326-1
更新日期:1997-02-01 00:00:00
abstract:PURPOSE:To investigate characteristics associated with visual and anatomic outcomes in branch and central retinal vein occlusion (BRVO and CRVO) patients treated with ranibizumab. DESIGN:Post hoc analysis of patients with BRVO and CRVO from 2 multicenter clinical trials who completed month 12 of the HORIZON extension ...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ophtha.2019.07.018
更新日期:2019-12-01 00:00:00
abstract::We encountered two clinically similar but genetically unrelated cases of a disorder characterized by an unusual white pupillary-iris-lens membrane with extension to a prominent Schwalbe's line, the membranes were vascularized and their appearance changed over time. In both cases the abnormality was unilateral. Anomalo...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33659-5
更新日期:1986-06-01 00:00:00
abstract::Warburg syndrome is a congenital oculocerebral disorder. It is caused by a genetic defect that simultaneously affects ocular and cerebral embryogenesis. The characteristic ophthalmic findings reflect the cerebral malformation (agyria or lissencephaly). Two cases, siblings, have been described. The characteristic bilat...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(83)34345-1
更新日期:1983-12-01 00:00:00
abstract:PURPOSE:To estimate retinal ganglion cell (RGC) losses associated with the earliest development of visual field defects in glaucoma. DESIGN:Observational cohort study. PARTICIPANTS:The study group included 53 eyes of 53 patients with suspected glaucoma who were followed as part of the Diagnostic Innovations in Glauco...
journal_title:Ophthalmology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.ophtha.2012.09.039
更新日期:2013-04-01 00:00:00
abstract::Optical penalization for distance is a useful alternative to occlusion for treating amblyopia, and as maintenance therapy following occlusion. It is particularly useful in cases of patching noncompliance. The major key to patient acceptance is choosing the minimal amount of penalization necessary, while still ensuring...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(85)33821-6
更新日期:1985-11-01 00:00:00
abstract::Aphakic cystoid macular edema (ACME) is a common condition seen after intracapsular cataract extractions. In an overwhelming majority of these cases, the condition improves spontaneously. Those cases that persist for months or years, however, are often associated with vitreous strands adherent to the surgical wound an...
journal_title:Ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0161-6420(82)34709-0
更新日期:1982-08-01 00:00:00
abstract:BACKGROUND:Malignant glaucoma (ciliary block glaucoma; aqueous misdirection glaucoma) is an incompletely understood, rare and serious complication of intraocular surgery. METHODS:A woman with pseudophakic malignant glaucoma underwent successful neodymium: YAG (Nd:YAG) laser photodisruption of the anterior hyaloid face...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(93)31479-x
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To determine whether multiple B-scan averaging improves the quality of spectral-domain optical coherence tomography (SD OCT) images of the retina. DESIGN:Prospective cross-sectional study. PARTICIPANTS:One hundred one eyes of 84 patients with various retinal diseases. METHODS:A prototype SD OCT system was ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2007.09.001
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:To investigate the association in Japanese between posterior vitreous attachment and the pathologies of typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV), 2 major forms of exudative AMD. DESIGN:Retrospective observational case series. PARTICIPANTS:A total of 378 eyes f...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2010.09.001
更新日期:2011-05-01 00:00:00
abstract::The effect of wearing schedule on extended-wear (EW) success was evaluated over a nine-month period by assigning 36 subjects to 5 different wearing schedules (removal every 4, 7, 14, or 28 days, or daily wear [DW]). All but one EW patient required interruption of extended wear at least once; half of the DW patients co...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(86)33768-0
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) and Toxoplasma gondii both cause necrotizing retinopathy in immunosuppressed hosts. Because of the high prevalence of serum antibodies to these agents in the general population and the risks associated with retinal biopsies, diagnosis of these infections is usually based on clinical fin...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(13)31267-6
更新日期:1994-03-01 00:00:00
abstract:PURPOSE:To examine the clinical features of undiagnosed open-angle glaucoma (OAG) in people who have attended an eye care provider within the previous 12 months and to suggest strategies to assist in the early detection of glaucoma. DESIGN:Population based cross-sectional study. PARTICIPANTS:Permanent residents aged ...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/j.ophtha.2004.01.029
更新日期:2004-08-01 00:00:00
abstract::A review of all cases of aponeurotic repair done since 1980 by the author identified 140 patients and 174 eyelids. An acceptable result at 6 weeks was defined as a lid level within 1 mm of the desired level achieved in 74% of lids with acquired ptosis. The amount of ptosis present preoperatively was the major factor i...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::Three hundred eight patients with strabismus were treated with botulinum A toxin (Oculinum) chemodenervation; 153 were followed by the authors for at least 6 months. In this study group, 97 received botulinum A toxin injections as the primary method of treatment of their ocular deviation. Fifty-six received injections...
journal_title:Ophthalmology
pub_type: 杂志文章
doi:10.1016/s0161-6420(89)32776-x
更新日期:1989-07-01 00:00:00