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Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behçet's Disease.

Abstract：

PURPOSE:To assess efficacy, safety, and cost-effectiveness of adalimumab (ADA) therapy optimization in a large series of patients with uveitis due to Behçet disease (BD) who achieved remission after the use of this biologic agent. DESIGN:Open-label multicenter study of ADA-treated patients with BD uveitis refractory to conventional immunosuppressants. SUBJECTS:Sixty-five of 74 patients with uveitis due to BD, who achieved remission after a median ADA duration of 6 (range, 3-12) months. ADA was optimized in 23 (35.4%) of them. This biologic agent was maintained at a dose of 40 mg/subcutaneously/2 weeks in the remaining 42 patients. METHODS:After remission, based on a shared decision between the patient and the treating physician, ADA was optimized. When agreement between patient and physician was reached, optimization was performed by prolonging the ADA dosing interval progressively. Comparison between optimized and nonoptimized patients was performed. MAIN OUTCOME MEASURES:Efficacy, safety, and cost-effectiveness in optimized and nonoptimized groups. To determine efficacy, intraocular inflammation (anterior chamber cells, vitritis, and retinal vasculitis), macular thickness, visual acuity, and the sparing effect of glucocorticoids were assessed. RESULTS:No demographic or ocular differences were found at the time of ADA onset between the optimized and the nonoptimized groups. Most ocular outcomes were similar after a mean ± standard deviation follow-up of 34.7±13.3 and 26±21.3 months in the optimized and nonoptimized groups, respectively. However, relevant adverse effects were only seen in the nonoptimized group (lymphoma, pneumonia, severe local reaction at the injection site, and bacteremia by Escherichia coli, 1 each). Moreover, the mean ADA treatment costs were lower in the optimized group than in the nonoptimized group (6101.25 euros/patient/year vs. 12 339.48; P < 0.01). CONCLUSION:ADA optimization in BD uveitis refractory to conventional therapy is effective, safe, and cost-effective.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Martín-Varillas JL,Calvo-Río V,Beltrán E,Sánchez-Bursón J,Mesquida M,Adán A,Hernandez MV,Garfella MH,Pascual EV,Martínez-Costa L,Sellas-Fernández A,Cordero-Coma M,Díaz-Llopis M,Gallego R,Salom D,Ortego N,García-Serrano JL

doi

10.1016/j.ophtha.2018.02.020

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1444-1451

issue

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(17)33390-0

journal_volume

125

pub_type

杂志文章,多中心研究,随机对照试验

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Successful Optimization of Adalimumab Therapy in Refractory Uveitis Due to Behçet's Disease.