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Optic Nerve Length before and after Spaceflight.

Abstract：

PURPOSE:The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to the International Space Station (ISS). The SANS has blurred vision and ocular changes as typical features. The objective of this study was to investigate if microgravity can create deformations or movements of the eye or optic nerve, and if such changes could be linked to SANS. DESIGN:Cohort study. PARTICIPANTS:Twenty-two astronauts (age 48 ± 4 years). METHODS:The intervention consisted of time in microgravity at the ISS. We co-registered pre- and postspaceflight magnetic resonance imaging (MRI) scans and generated centerline representations of the optic nerve. The coordinates for the optic nerve head (ONH) and optic chiasm (OC) ends of the optic nerve were recorded along with the entire centerline path. MAIN OUTCOME MEASURES:Optic nerve length, ONH movement, and OC movement after time in microgravity. RESULTS:Optic nerve length increased (0.80 ± 0.74 mm, P < 0.001), primarily reflecting forward ONH displacement (0.63 ± 0.53 mm, P < 0.001). The forward displacement was positively related to mission duration, preflight body weight, and clinical manifestations of SANS. We also detected upward displacement of the OC (0.39 ± 0.50 mm, P = 0.002), indicative of brain movement, but this observation could not be linked to SANS. CONCLUSIONS:The spaceflight-induced optic nerve lengthening and anterior movement of the ONH support that SANS is caused by an altered pressure difference between the brain and the eye, leading to a forward push on the posterior of the eye. Body weight is a potential contributing risk factor. Direct assessment of intracranial pressure in space is required to verify the implicated mechanism behind the ocular findings in SANS.

journal_name

Ophthalmology

journal_title

Ophthalmology

authors

Wåhlin A,Holmlund P,Fellows AM,Malm J,Buckey JC,Eklund A

doi

10.1016/j.ophtha.2020.07.007

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

309-316

issue

2

eissn

0161-6420

issn

1549-4713

pii

S0161-6420(20)30640-0

journal_volume

128

pub_type

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