Abstract:
:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test systems used to assess the sensitizing potential of chemicals for humans. In vitrosystems range from single cell cultures to organotypic multi-cellular reconstructed skin models. Until now, their metabolic competence to unmask sensitizing potential of pro-sensitizers was rarely investigated. This review aims to summarize current information on available skin in vitro models and the relevance of xenobiotic metabolizing enzymes for the activation of pro-sensitizers such as eugenol, 4-allylanisole, and ethylendiamine. Among others, these chemicals are discussed as performance standards to validate new coming in vitro systems for their potential to identify pro-sensitizers.
journal_name
J Immunotoxicoljournal_title
Journal of immunotoxicologyauthors
Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel Rdoi
10.3109/1547691X.2012.664578subject
Has Abstractpub_date
2012-10-01 00:00:00pages
426-38issue
4eissn
1547-691Xissn
1547-6901journal_volume
9pub_type
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