Abstract:
:Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induced nephropathy remains unknown. The aim of this study was to determine the role of Ang II in the oxidative stress and renal infiltration of CD8(+) T-cells after an acute HgCl2 intoxication. Three groups of Sprague Dawley rats were treated with a single subcutaneous dose of 2.5 mg/kg HgCl2: for 3 days prior to and for 4 days after that injection, rats in one group received Losartan (30 mg/kg), in another group Enalapril (30 mg/kg) or normal saline in the last group. Two other groups of drug-treated rats received saline in place of HgCl2. A final group of rats received saline in place of HgCl2 and the test drugs. All treatments were via gastric gavage. At 96 h after the vehicle/HgCl2 injection, blood and kidney samples were harvested. Renal sections were homogenized for measures of malondialdehyde (MDA), reduced glutathione (GSH) and catalase activity. Frozen sections were studied for the presence of superoxide anion ([Formula: see text]) and CD8(+) T-cells. HgCl2-treated rats had increased interstitial and tubular expression of [Formula: see text], high levels of MDA, normal catalase activity and GSH content, increased levels of interstitial CD8(+) T-cells and an increased percentage of necrotic tubules. Anti-Ang II treatments diminished the HgCl2-induced increases in interstitial [Formula: see text], CD8(+) T-cells and tubular damage and increased catalase and GSH expression above that due to HgCl2 alone; the HgCl2-induced high MDA levels were unaffected by the drugs. These data provide new information regarding the potential role of Ang II in the oxidative stress and renal CD8(+) T-cell infiltration that occur during HgCl2 nephropathy.
journal_name
J Immunotoxicoljournal_title
Journal of immunotoxicologyauthors
Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera Jdoi
10.3109/1547691X.2015.1089960subject
Has Abstractpub_date
2016-05-01 00:00:00pages
324-34issue
3eissn
1547-691Xissn
1547-6901journal_volume
13pub_type
杂志文章abstract::A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2013.766287
更新日期:2014-01-01 00:00:00
abstract::Among the different phenotypic changes induced by contact sensitizers in dendritic cells and myeloid cell lines, CD86 appears to be a consensus marker, since constantly described as systematically up-regulated. To evaluate the robustness of this marker, interference of cytotoxicity on CD86 expression was investigated ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910600978038
更新日期:2006-12-01 00:00:00
abstract::Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1142488
更新日期:2016-07-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.978055
更新日期:2015-01-01 00:00:00
abstract::Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2011.642103
更新日期:2012-01-01 00:00:00
abstract::In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.880535
更新日期:2015-01-01 00:00:00
abstract::Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2017.1346009
更新日期:2017-12-01 00:00:00
abstract::Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910903023060
更新日期:2009-09-01 00:00:00
abstract::The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1017060
更新日期:2016-01-01 00:00:00
abstract::Here we sought to determine whether prenatal exposure to subtoxic levels of inorganic mercury induced modulations in the fetal immune repertoire. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. DBF(1) pups were examined at day...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701680178
更新日期:2007-10-01 00:00:00
abstract::Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.691124
更新日期:2013-01-01 00:00:00
abstract::Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.712066
更新日期:2013-07-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2018.1474978
更新日期:2018-12-01 00:00:00
abstract::As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.691123
更新日期:2013-01-01 00:00:00
abstract::Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910490496249
更新日期:2004-04-01 00:00:00
abstract::The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1106622
更新日期:2016-05-01 00:00:00
abstract::Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1134731
更新日期:2016-07-01 00:00:00
abstract::Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.708366
更新日期:2013-04-01 00:00:00
abstract::In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2019.1699617
更新日期:2020-12-01 00:00:00
abstract::Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701385570
更新日期:2007-07-01 00:00:00
abstract::That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15376510802312324
更新日期:2008-07-01 00:00:00
abstract::Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1046572
更新日期:2016-01-01 00:00:00
abstract::Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2013.860644
更新日期:2014-10-01 00:00:00
abstract::There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1755397
更新日期:2020-12-01 00:00:00
abstract::The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors of...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.700652
更新日期:2013-04-01 00:00:00
abstract::Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701336953
更新日期:2007-04-01 00:00:00
abstract::Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.917749
更新日期:2015-04-01 00:00:00
abstract::Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2017.1394934
更新日期:2017-12-01 00:00:00
abstract::An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910500241339
更新日期:2005-07-01 00:00:00
abstract::The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802604317
更新日期:2009-03-01 00:00:00