Abstract:
:There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case of cervical cancer, inflammation is an important factor associated with the development, progression, and potential metastasis of the disease. What is unclear still in the potential for modifications of host responses to human papillomaviruses (HPV) - a known causative agent of CC, that could be induced by cigarette smoking. In particular, it remains to be determined how the inflammation induced by HPV infection could impact on CC incidence/severity. In this prospective study, serum levels of 10 cytokines were evaluated using Multiplex and ELISA assays. The samples were the sera of 43 CC patients and 60 healthy (NILM) controls. All outcomes were evaluated in relation to host HPV and to their smoking status. The results in indicated that serum sTREM-1, TNFα, IFNβ, IL-1β, and IL-6 levels were significantly increased in CC (HPV+) patients compared to healthy NILM controls. A similar trend was observed for IL-10 and IL-2 levels. Within the two groups, differences in cytokine levels between smokers and never smokers were not remarkable. The findings here support the hypothesized role of systemic inflammation in the pathophysiology of CC.
journal_name
J Immunotoxicoljournal_title
Journal of immunotoxicologyauthors
Vitkauskaite A,Urboniene D,Celiesiute J,Jariene K,Skrodeniene E,Nadisauskiene RJ,Vaitkiene Ddoi
10.1080/1547691X.2020.1755397subject
Has Abstractpub_date
2020-12-01 00:00:00pages
105-109issue
1eissn
1547-691Xissn
1547-6901journal_volume
17pub_type
杂志文章abstract::In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.1080/15476910802482870
更新日期:2008-10-01 00:00:00
abstract::The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2013.821564
更新日期:2014-04-01 00:00:00
abstract::Mechanical ventilation with hyperoxia is a necessary treatment for patients with respiratory distress. However, patients on mechanical ventilation have increased susceptibility to infection. Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2010.531063
更新日期:2011-01-01 00:00:00
abstract::The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2019.1604585
更新日期:2019-12-01 00:00:00
abstract::Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including ant...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.684159
更新日期:2013-01-01 00:00:00
abstract::The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1106622
更新日期:2016-05-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.978055
更新日期:2015-01-01 00:00:00
abstract::Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2016.1184360
更新日期:2016-11-01 00:00:00
abstract::Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1142019
更新日期:2016-07-01 00:00:00
abstract::Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802131477
更新日期:2008-04-01 00:00:00
abstract::The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1826020
更新日期:2020-12-01 00:00:00
abstract::Among the different phenotypic changes induced by contact sensitizers in dendritic cells and myeloid cell lines, CD86 appears to be a consensus marker, since constantly described as systematically up-regulated. To evaluate the robustness of this marker, interference of cytotoxicity on CD86 expression was investigated ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910600978038
更新日期:2006-12-01 00:00:00
abstract::That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15376510802312324
更新日期:2008-07-01 00:00:00
abstract::Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor immunotherapies has been modest compared to their theoretical and pre-clinical promise. This review evaluates the promise and pitfalls of immunotherapy and highli...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.685527
更新日期:2012-07-01 00:00:00
abstract::In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.707696
更新日期:2013-04-01 00:00:00
abstract::Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701336953
更新日期:2007-04-01 00:00:00
abstract::Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1154118
更新日期:2016-09-01 00:00:00
abstract::First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.914609
更新日期:2015-04-01 00:00:00
abstract::The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2010.509848
更新日期:2010-10-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2018.1474978
更新日期:2018-12-01 00:00:00
abstract::The objective of this study was to characterize the variability of rat lymphoid organ weights and morphology following treatment with a known immunotoxicant, with a focus on the usefulness of evaluating popliteal lymph node weight and histology. Cyclophosphamide was administered to male Sprague-Dawley rats by oral gav...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1122117
更新日期:2016-07-01 00:00:00
abstract::Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701385570
更新日期:2007-07-01 00:00:00
abstract::Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1046572
更新日期:2016-01-01 00:00:00
abstract::Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.708366
更新日期:2013-04-01 00:00:00
abstract::Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.664578
更新日期:2012-10-01 00:00:00
abstract::Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1142488
更新日期:2016-07-01 00:00:00
abstract::Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910500468627
更新日期:2006-01-01 00:00:00
abstract::Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.712066
更新日期:2013-07-01 00:00:00
abstract::As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.691123
更新日期:2013-01-01 00:00:00
abstract::Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2018.1460425
更新日期:2018-12-01 00:00:00