Abstract:
:The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 1254) - with or without co-treatment with 75, 150, or 300 mg/kg quercetin - on gestation days (GD) 4-7. At GD 9, all rats were euthanized, and their blood, liver, and uterus were collected. Expressions of CYP450 mRNA and protein in liver, cytokines (IFNγ, IL-2, IL-4, and IL-6) and IFNγ/IL-4 ratios in liver and sera, liver morphology, and the status of implanted embryos were analyzed. The results showed Aroclor 1254 treatment alone caused hepatic cord damage (i.e. cell disorganization, swelling, decreased cytoplasm, vacuolization), and that quercetin co-treatment appeared to mitigate this damage. Similarly, levels of CYP1A1 and CYP2B1 mRNA in livers of Aroclor 1254-only-treated rats were significantly higher than those in rats co-treated with quercetin. Hepatic and sera levels of IFNγ, IL-2, IL-6, and IFNγ/IL-4 ratios, and the ratio of delayed-development embryos, all increased in Aroclor 1254-treated rats, but were relatively decreased as a result of quercetin co-treatments. IL-4 levels were decreased by Aroclor 1254 and tended to increase back to normal when quercetin was used. The results indicated that quercetin imparted a protective effect against Aroclor 1254-induced toxicity in pregnant rats, in part, by modulating levels of important pro-inflammatory cytokines and reducing induced CYP1A1 and CYP2B1 expression.
journal_name
J Immunotoxicoljournal_title
Journal of immunotoxicologyauthors
Xu L,Guo X,Li N,Pan Q,Ma YZdoi
10.1080/1547691X.2019.1604585subject
Has Abstractpub_date
2019-12-01 00:00:00pages
140-148issue
1eissn
1547-691Xissn
1547-6901journal_volume
16pub_type
杂志文章abstract::Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1142019
更新日期:2016-07-01 00:00:00
abstract::The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1826020
更新日期:2020-12-01 00:00:00
abstract::Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2017.1346009
更新日期:2017-12-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.978055
更新日期:2015-01-01 00:00:00
abstract::There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1755397
更新日期:2020-12-01 00:00:00
abstract::Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1154118
更新日期:2016-09-01 00:00:00
abstract::Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910903023060
更新日期:2009-09-01 00:00:00
abstract::As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.691123
更新日期:2013-01-01 00:00:00
abstract::Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1142488
更新日期:2016-07-01 00:00:00
abstract::Toxicological testing of compounds often is conducted at the maximum tolerated dose to identify potential target organs. Toxicities observed at these high doses may result in decreased body weight gain, food consumption and activity. These clinical signs are often associated with a generalized stress response. It has ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910601115150
更新日期:2007-01-01 00:00:00
abstract::First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.914609
更新日期:2015-04-01 00:00:00
abstract::In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.880535
更新日期:2015-01-01 00:00:00
abstract::In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.1080/15476910802482870
更新日期:2008-10-01 00:00:00
abstract::Vanadium, an important air pollutant derived from fuel product combustion, aggravates respiratory diseases and impairs cardiovascular function. In contrast, its effects on immune response are conflicting. The aim of our work was to determine if spleens of vanadium-exposed CD1 mice showed histological lesions that migh...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802085749
更新日期:2008-04-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2018.1474978
更新日期:2018-12-01 00:00:00
abstract::The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1106622
更新日期:2016-05-01 00:00:00
abstract::Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1804492
更新日期:2020-12-01 00:00:00
abstract::Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1120829
更新日期:2016-05-01 00:00:00
abstract::Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2013.860644
更新日期:2014-10-01 00:00:00
abstract::Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.917749
更新日期:2015-04-01 00:00:00
abstract::The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1139643
更新日期:2016-07-01 00:00:00
abstract::Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1089960
更新日期:2016-05-01 00:00:00
abstract::An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910500241339
更新日期:2005-07-01 00:00:00
abstract::Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802131477
更新日期:2008-04-01 00:00:00
abstract::The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1017060
更新日期:2016-01-01 00:00:00
abstract::Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2011.642103
更新日期:2012-01-01 00:00:00
abstract::That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15376510802312324
更新日期:2008-07-01 00:00:00
abstract::Hexachlorobenzene (HCB) is an environmental pollutant that induces adverse immune effects in humans and rats. Brown Norway rats (BN) appear to be very susceptible to HCB-induced immune effects. Oral exposure causes inflammatory skin and lung lesions, enlarged spleen and lymph nodes (LN) and elevated humoral responses....
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910490907026
更新日期:2005-07-01 00:00:00
abstract::Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701336953
更新日期:2007-04-01 00:00:00
abstract::Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.712066
更新日期:2013-07-01 00:00:00