A preliminary assessment of relative sensitivities to foreign red blood cell challenges in the northern bobwhite for potential evaluation of immunotoxicity.

abstract：:In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...

journal_title：Journal of immunotoxicology

authors： Seliger B

更新日期：2008-10-01 00:00:00

abstract：:Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

journal_title：Journal of immunotoxicology

authors： El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

更新日期：2016-07-01 00:00:00

abstract：:Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...

journal_title：Journal of immunotoxicology

authors： Frawley RP,Smith MJ,White KL Jr,Elmore SA,Herbert R,Moore R,Staska LM,Behl M,Hooth MJ,Kissling GE,Germolec DR

更新日期：2016-09-01 00:00:00

abstract：:The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...

journal_title：Journal of immunotoxicology

authors： Cetkovic-Cvrlje M,Olson M,Schindler B,Gong HK

更新日期：2016-01-01 00:00:00

abstract：:Hexachlorobenzene (HCB) is an environmental pollutant that induces adverse immune effects in humans and rats. Brown Norway rats (BN) appear to be very susceptible to HCB-induced immune effects. Oral exposure causes inflammatory skin and lung lesions, enlarged spleen and lymph nodes (LN) and elevated humoral responses....

journal_title：Journal of immunotoxicology

authors： Ezendam J,Vos JG,Pieters R

更新日期：2005-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...

journal_title：Journal of immunotoxicology

authors： El-Sisi AE,Sokar SS,Salem TA,Abu Risha SE

更新日期：2015-01-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

journal_title：Journal of immunotoxicology

authors： Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

更新日期：2016-01-01 00:00:00

abstract：:Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...

journal_title：Journal of immunotoxicology

authors： Antoine F,Girard D

更新日期：2015-04-01 00:00:00

abstract：:The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...

journal_title：Journal of immunotoxicology

authors： Galbiati V,Mitjans M,Corsini E

更新日期：2010-10-01 00:00:00

abstract：:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

journal_title：Journal of immunotoxicology

authors： Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

更新日期：2012-10-01 00:00:00

abstract：:The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

journal_title：Journal of immunotoxicology

authors： Ratanji KD,Derrick JP,Dearman RJ,Kimber I

更新日期：2014-04-01 00:00:00

abstract：:Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...

journal_title：Journal of immunotoxicology

authors： Rodriguez-Lara V,Muñiz-Rivera Cambas A,González Villalva A,Fortoul TI

更新日期：2016-07-01 00:00:00

abstract：:Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

journal_title：Journal of immunotoxicology

authors： Inada T,Ueshima H,Shingu K

更新日期：2013-07-01 00:00:00

abstract：:Workers exposed to benzene frequently suffer from toxicities of the bone marrow as well as the central nervous, immune, and reproductive systems. This toxicity most likely is a result of the oxidative metabolism of benzene to reactive products. As green tea possesses antioxidant effects, the objective of this study wa...

journal_title：Journal of immunotoxicology

authors： Emara AM,El-Bahrawy H

更新日期：2008-01-01 00:00:00

abstract：:Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...

journal_title：Journal of immunotoxicology

authors： Springs AE,Rice CD

更新日期：2006-01-01 00:00:00

abstract：:The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...

journal_title：Journal of immunotoxicology

authors： Vetvicka V,Vetvickova J

更新日期：2009-03-01 00:00:00

abstract：:An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Tsutsui N,Hisada S,Vidal JM,Spanhaak S,Sawada J,Hastings KL,van der Laan JW,van Loveren H,Kawabata TT,Sims J,Durham SK,Fueki O,Matula TI,Kusunoki H,Ulrich P,Nakamura K

更新日期：2005-07-01 00:00:00

abstract：:Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...

journal_title：Journal of immunotoxicology

authors： Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera J

更新日期：2016-05-01 00:00:00

abstract：:In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

journal_title：Journal of immunotoxicology

authors： Kimber I,Pieters R

更新日期：2013-04-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00

abstract：:Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

journal_title：Journal of immunotoxicology

authors： Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

更新日期：2016-07-01 00:00:00

abstract：:Previously, we showed that in utero exposure to mercury induced phenotypic changes in fetal immune cells. Here, we sought to determine whether the effects of in utero exposure on immune cells persisted in the adult. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in dr...

journal_title：Journal of immunotoxicology

authors： Pilones K,Tatum A,Gavalchin J

更新日期：2009-09-01 00:00:00

abstract：:Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...

journal_title：Journal of immunotoxicology

authors： Oostingh GJ,Wichmann G,Schmittner M,Lehmann I,Duschl A

更新日期：2009-06-01 00:00:00

abstract：:The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors of...

journal_title：Journal of immunotoxicology

authors： Glushkova OV,Parfenyuk SB,Khrenov MO,Novoselova TV,Lunin SM,Fesenko EE,Novoselova EG

更新日期：2013-04-01 00:00:00

abstract：:Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

journal_title：Journal of immunotoxicology

authors： Metushi IG,Uetrecht J

更新日期：2014-10-01 00:00:00

abstract：:The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...

journal_title：Journal of immunotoxicology

authors： Poirier M,Simard JC,Girard D

更新日期：2016-05-01 00:00:00

abstract：:Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

journal_title：Journal of immunotoxicology

authors： Terhune TD,Deth RC

更新日期：2013-04-01 00:00:00

abstract：:First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

journal_title：Journal of immunotoxicology

authors： Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

更新日期：2015-04-01 00:00:00

abstract：:A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...

journal_title：Journal of immunotoxicology

authors： Kamperschroer C,O'Donnell LM,Schneider PA,Li D,Roy M,Coskran TM,Kawabata TT

更新日期：2014-01-01 00:00:00