Different regulation of MHC class I antigen processing components in human tumors.

abstract：:The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

journal_title：Journal of immunotoxicology

authors： Ratanji KD,Derrick JP,Dearman RJ,Kimber I

更新日期：2014-04-01 00:00:00

abstract：:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

journal_title：Journal of immunotoxicology

authors： Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

更新日期：2012-10-01 00:00:00

abstract：:In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

journal_title：Journal of immunotoxicology

authors： Kimber I,Pieters R

更新日期：2013-04-01 00:00:00

abstract：:Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...

journal_title：Journal of immunotoxicology

authors： Oostingh GJ,Wichmann G,Schmittner M,Lehmann I,Duschl A

更新日期：2009-06-01 00:00:00

abstract：:Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...

journal_title：Journal of immunotoxicology

authors： Avila S,Muñoz-García L,Vázquez-Leyva S,Salinas-Jazmín N,Medina-Rivero E,Pavón L,Mellado-Sánchez G,Chacón-Salinas R,Estrada-Parra S,Vallejo-Castillo L,Pérez-Tapia SM

更新日期：2017-12-01 00:00:00

abstract：:Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...

journal_title：Journal of immunotoxicology

authors： Sarlo K,Adamson GM,Hollis VL,Innis JD,Babcock LS,Kirchner DB

更新日期：2004-04-01 00:00:00

abstract：:Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...

journal_title：Journal of immunotoxicology

authors： Brand JD,Mathews JA,Kasahara DI,Wurmbrand AP,Shore SA

更新日期：2016-05-01 00:00:00

abstract：:Previously, we showed that in utero exposure to mercury induced phenotypic changes in fetal immune cells. Here, we sought to determine whether the effects of in utero exposure on immune cells persisted in the adult. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in dr...

journal_title：Journal of immunotoxicology

authors： Pilones K,Tatum A,Gavalchin J

更新日期：2009-09-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...

journal_title：Journal of immunotoxicology

authors： El-Sisi AE,Sokar SS,Salem TA,Abu Risha SE

更新日期：2015-01-01 00:00:00

abstract：:Hexachlorobenzene (HCB) is an environmental pollutant that induces adverse immune effects in humans and rats. Brown Norway rats (BN) appear to be very susceptible to HCB-induced immune effects. Oral exposure causes inflammatory skin and lung lesions, enlarged spleen and lymph nodes (LN) and elevated humoral responses....

journal_title：Journal of immunotoxicology

authors： Ezendam J,Vos JG,Pieters R

更新日期：2005-07-01 00:00:00

abstract：:The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...

journal_title：Journal of immunotoxicology

authors： Poirier M,Simard JC,Girard D

更新日期：2016-05-01 00:00:00

abstract：:Vanadium, an important air pollutant derived from fuel product combustion, aggravates respiratory diseases and impairs cardiovascular function. In contrast, its effects on immune response are conflicting. The aim of our work was to determine if spleens of vanadium-exposed CD1 mice showed histological lesions that migh...

journal_title：Journal of immunotoxicology

authors： Pinon-Zarate G,Rodriguez-Lara V,Rojas-Lemus M,Martinez-Pedraza M,Gonzalez-Villalva A,Mussali-Galante P,Fortoul TI,Barquet A,Masso F,Montano LF

更新日期：2008-04-01 00:00:00

abstract：:Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

journal_title：Journal of immunotoxicology

authors： Metushi IG,Uetrecht J

更新日期：2014-10-01 00:00:00

abstract：:Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...

journal_title：Journal of immunotoxicology

authors： Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JA

更新日期：2018-12-01 00:00:00

abstract：:Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

journal_title：Journal of immunotoxicology

authors： Peillex C,Pelletier M

更新日期：2020-12-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...

journal_title：Journal of immunotoxicology

authors： Anderson SE,Franko J,Anderson KL,Munson AE,Lukomska E,Meade BJ

更新日期：2013-01-01 00:00:00

abstract：:The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...

journal_title：Journal of immunotoxicology

authors： Galbiati V,Mitjans M,Corsini E

更新日期：2010-10-01 00:00:00

abstract：:Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor immunotherapies has been modest compared to their theoretical and pre-clinical promise. This review evaluates the promise and pitfalls of immunotherapy and highli...

journal_title：Journal of immunotoxicology

authors： Monjazeb AM,Hsiao HH,Sckisel GD,Murphy WJ

更新日期：2012-07-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including ant...

journal_title：Journal of immunotoxicology

authors： Popov A,Belij S,Subota V,Zolotarevski L,Mirkov I,Kataranovski D,Kataranovski M

更新日期：2013-01-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...

journal_title：Journal of immunotoxicology

authors： Xu L,Guo X,Li N,Pan Q,Ma YZ

更新日期：2019-12-01 00:00:00

abstract：:A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...

journal_title：Journal of immunotoxicology

authors： Kamperschroer C,O'Donnell LM,Schneider PA,Li D,Roy M,Coskran TM,Kawabata TT

更新日期：2014-01-01 00:00:00

abstract：:There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case ...

journal_title：Journal of immunotoxicology

authors： Vitkauskaite A,Urboniene D,Celiesiute J,Jariene K,Skrodeniene E,Nadisauskiene RJ,Vaitkiene D

更新日期：2020-12-01 00:00:00

abstract：:Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

journal_title：Journal of immunotoxicology

authors： Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

更新日期：2016-07-01 00:00:00

abstract：:Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

journal_title：Journal of immunotoxicology

authors： Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

更新日期：2016-01-01 00:00:00

abstract：:Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

journal_title：Journal of immunotoxicology

authors： Terhune TD,Deth RC

更新日期：2013-04-01 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...

journal_title：Journal of immunotoxicology

authors： Dahlén E,Barchan K,Herrlander D,Höjman P,Karlsson M,Ljung L,Andersson M,Bäckman E,Hager AC,Walse B,Joosten L,van den Berg W

更新日期：2008-04-01 00:00:00

abstract：:An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Tsutsui N,Hisada S,Vidal JM,Spanhaak S,Sawada J,Hastings KL,van der Laan JW,van Loveren H,Kawabata TT,Sims J,Durham SK,Fueki O,Matula TI,Kusunoki H,Ulrich P,Nakamura K

更新日期：2005-07-01 00:00:00

abstract：:In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

journal_title：Journal of immunotoxicology

authors： Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

更新日期：2020-12-01 00:00:00

abstract：:That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...

journal_title：Journal of immunotoxicology

authors： Urso P,Wirsiy YG,Zhang W,Moolenaar-Wirsiy PJ

更新日期：2008-07-01 00:00:00