Abstract:
:Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but comparison effects in females are unknown. Using an intranasal inhalation exposure model, 8-week-old C57BL/6 male and female mice were treated daily with LPS (100 ng) or saline for 3 weeks. Bronchoalveolar lavage fluids, lung tissues, tibias, bone marrow cells, and blood were collected. LPS-induced airway neutrophil influx, interleukin (IL)-6 and neutrophil chemoattractant levels, and bronchiolar inflammation were exaggerated in male animals as compared to female mice. Trabecular bone micro-CT imaging and analysis of the proximal tibia were conducted. Inhalant LPS exposures lead to deterioration of bone quality only in male mice (not females) marked by decreased bone mineral density, bone volume/tissue volume ratio, trabecular thickness and number, and increased bone surface-to-bone volume ratio. Serum pentraxin-2 levels were modulated by sex differences and LPS exposure. In proof-of-concept studies, ovarectomized female mice demonstrated LPS-induced bone deterioration, and estradiol supplementation of ovarectomized female mice and control male mice protected against LPS-induced bone deterioration findings. Collectively, sex-specific differences exist in LPS-induced airway inflammatory consequences with significant differences found in bone quantity and quality parameters. Male mice demonstrated susceptibility to bone loss and female animals were protected, which was modulated by estrogen. Therefore, sex differences influence the biologic response in the lung-bone inflammatory axis in response to inhalant LPS exposures.
journal_name
J Immunotoxicoljournal_title
Journal of immunotoxicologyauthors
Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JAdoi
10.1080/1547691X.2018.1460425subject
Has Abstractpub_date
2018-12-01 00:00:00pages
73-81issue
1eissn
1547-691Xissn
1547-6901journal_volume
15pub_type
杂志文章abstract::The concept of immunological surveillance implies that immunogenic variants of tumor cells arising in the organism can be recognized by the immune system. Tumor progression is provided by somatic evolution of tumor cells under the pressure of the immune system. The loss of MHC Class I molecules on the surface of tumor...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2013.861548
更新日期:2014-10-01 00:00:00
abstract::Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1046572
更新日期:2016-01-01 00:00:00
abstract::The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802604317
更新日期:2009-03-01 00:00:00
abstract::Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.708366
更新日期:2013-04-01 00:00:00
abstract::Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802131477
更新日期:2008-04-01 00:00:00
abstract::Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910902977407
更新日期:2009-06-01 00:00:00
abstract::The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2010.509848
更新日期:2010-10-01 00:00:00
abstract::Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor immunotherapies has been modest compared to their theoretical and pre-clinical promise. This review evaluates the promise and pitfalls of immunotherapy and highli...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.685527
更新日期:2012-07-01 00:00:00
abstract::Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2013.860644
更新日期:2014-10-01 00:00:00
abstract::Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2017.1394934
更新日期:2017-12-01 00:00:00
abstract::That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15376510802312324
更新日期:2008-07-01 00:00:00
abstract::The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2019.1604585
更新日期:2019-12-01 00:00:00
abstract::The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1139643
更新日期:2016-07-01 00:00:00
abstract::Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2011.642103
更新日期:2012-01-01 00:00:00
abstract::Here we sought to determine whether prenatal exposure to subtoxic levels of inorganic mercury induced modulations in the fetal immune repertoire. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. DBF(1) pups were examined at day...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701680178
更新日期:2007-10-01 00:00:00
abstract::Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2020.1804492
更新日期:2020-12-01 00:00:00
abstract::Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2017.1346009
更新日期:2017-12-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.978055
更新日期:2015-01-01 00:00:00
abstract::Mechanical ventilation with hyperoxia is a necessary treatment for patients with respiratory distress. However, patients on mechanical ventilation have increased susceptibility to infection. Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2010.531063
更新日期:2011-01-01 00:00:00
abstract::Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.691124
更新日期:2013-01-01 00:00:00
abstract::Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/1547691X.2012.664578
更新日期:2012-10-01 00:00:00
abstract::In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/1547691X.2019.1699617
更新日期:2020-12-01 00:00:00
abstract::Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2016.1154118
更新日期:2016-09-01 00:00:00
abstract::Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2015.1134731
更新日期:2016-07-01 00:00:00
abstract::Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910500468627
更新日期:2006-01-01 00:00:00
abstract::In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2012.707696
更新日期:2013-04-01 00:00:00
abstract::Vanadium, an important air pollutant derived from fuel product combustion, aggravates respiratory diseases and impairs cardiovascular function. In contrast, its effects on immune response are conflicting. The aim of our work was to determine if spleens of vanadium-exposed CD1 mice showed histological lesions that migh...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910802085749
更新日期:2008-04-01 00:00:00
abstract::The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid i...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章,评审
doi:10.3109/15476910903334343
更新日期:2009-12-01 00:00:00
abstract::In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.3109/1547691X.2014.880535
更新日期:2015-01-01 00:00:00
abstract::Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...
journal_title:Journal of immunotoxicology
pub_type: 杂志文章
doi:10.1080/15476910701336953
更新日期:2007-04-01 00:00:00