Transferon™, a peptide mixture with immunomodulatory properties is not immunogenic when administered with various adjuvants.

abstract：:Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...

journal_title：Journal of immunotoxicology

authors： Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JA

更新日期：2018-12-01 00:00:00

abstract：:As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...

journal_title：Journal of immunotoxicology

authors： Zhang YH,Wang J,Dong GH,Liu MM,Wang D,Zheng L,Jin YH

更新日期：2013-01-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...

journal_title：Journal of immunotoxicology

authors： Anderson SE,Franko J,Anderson KL,Munson AE,Lukomska E,Meade BJ

更新日期：2013-01-01 00:00:00

abstract：:In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

journal_title：Journal of immunotoxicology

authors： Kimber I,Pieters R

更新日期：2013-04-01 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of the pro-inflammatory interleukin-1-mediated activation of the interleukin-1 receptor (IL-1R). Although wild-type IL-1Ra is used for treatment of inflammatory diseases, its effect is moderate and/or short-lived. The objective of this study...

journal_title：Journal of immunotoxicology

authors： Dahlén E,Barchan K,Herrlander D,Höjman P,Karlsson M,Ljung L,Andersson M,Bäckman E,Hager AC,Walse B,Joosten L,van den Berg W

更新日期：2008-04-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...

journal_title：Journal of immunotoxicology

authors： Laule CF,Wing CR,Odean EJ,Wilcox JA,Gilbert JS,Regal JF

更新日期：2017-12-01 00:00:00

abstract：:The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...

journal_title：Journal of immunotoxicology

authors： Vetvicka V,Vetvickova J

更新日期：2009-03-01 00:00:00

abstract：:Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...

journal_title：Journal of immunotoxicology

authors： Dobrakowski M,Boroń M,Czuba ZP,Kasperczyk A,Machoń-Grecka A,Kasperczyk S

更新日期：2016-11-01 00:00:00

abstract：:Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

journal_title：Journal of immunotoxicology

authors： Inada T,Ueshima H,Shingu K

更新日期：2013-07-01 00:00:00

abstract：:The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

journal_title：Journal of immunotoxicology

authors： Ratanji KD,Derrick JP,Dearman RJ,Kimber I

更新日期：2014-04-01 00:00:00

abstract：:Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

journal_title：Journal of immunotoxicology

authors： El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

更新日期：2016-07-01 00:00:00

abstract：:Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

journal_title：Journal of immunotoxicology

authors： Peillex C,Pelletier M

更新日期：2020-12-01 00:00:00

abstract：:Mechanical ventilation with hyperoxia is a necessary treatment for patients with respiratory distress. However, patients on mechanical ventilation have increased susceptibility to infection. Studies including ours have shown that reactive oxygen species (ROS), generated by exposure to prolonged hyperoxia, can cause a ...

journal_title：Journal of immunotoxicology

authors： Phan BD,Entezari M,Lockshin RA,Bartelt DC,Mantell LL

更新日期：2011-01-01 00:00:00

abstract：:That benzo alpha)pyrene (Balpha P) decreases both humoral and cell-mediated immunity, and leads to increases in progeny tumor development after in utero insult, suggests that T- and B-lymphocytes are made defective in exposed offspring. In the study here, C3H mice were injected once with Balpha P (150 microg/g BW) at ...

journal_title：Journal of immunotoxicology

authors： Urso P,Wirsiy YG,Zhang W,Moolenaar-Wirsiy PJ

更新日期：2008-07-01 00:00:00

abstract：:Toxicological testing of compounds often is conducted at the maximum tolerated dose to identify potential target organs. Toxicities observed at these high doses may result in decreased body weight gain, food consumption and activity. These clinical signs are often associated with a generalized stress response. It has ...

journal_title：Journal of immunotoxicology

authors： Pruett S,Hebert P,Lapointe JM,Reagan W,Lawton M,Kawabata TT

更新日期：2007-01-01 00:00:00

abstract：:Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...

journal_title：Journal of immunotoxicology

authors： Antonini JM,Roberts JR

更新日期：2007-04-01 00:00:00

abstract：:Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including ant...

journal_title：Journal of immunotoxicology

authors： Popov A,Belij S,Subota V,Zolotarevski L,Mirkov I,Kataranovski D,Kataranovski M

更新日期：2013-01-01 00:00:00

abstract：:Among the different phenotypic changes induced by contact sensitizers in dendritic cells and myeloid cell lines, CD86 appears to be a consensus marker, since constantly described as systematically up-regulated. To evaluate the robustness of this marker, interference of cytotoxicity on CD86 expression was investigated ...

journal_title：Journal of immunotoxicology

authors： Ade N,Martinozzi-Teissier S,Pallardy M,Rousset F

更新日期：2006-12-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...

journal_title：Journal of immunotoxicology

authors： El-Sisi AE,Sokar SS,Salem TA,Abu Risha SE

更新日期：2015-01-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00

abstract：:Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...

journal_title：Journal of immunotoxicology

authors： Oostingh GJ,Wichmann G,Schmittner M,Lehmann I,Duschl A

更新日期：2009-06-01 00:00:00

abstract：:Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...

journal_title：Journal of immunotoxicology

authors： Quinn MJ Jr,McFarland CA,LaFiandra EM,Johnson MS

更新日期：2009-09-01 00:00:00

abstract：:Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...

journal_title：Journal of immunotoxicology

authors： Springs AE,Rice CD

更新日期：2006-01-01 00:00:00

abstract：:The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...

journal_title：Journal of immunotoxicology

authors： Kwast L,Fiechter D,Kruijssen L,Bleumink R,Ludwig I,Bol-Schoenmakers M,Smit J,Pieters R

更新日期：2016-07-01 00:00:00

abstract：:In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

journal_title：Journal of immunotoxicology

authors： Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

更新日期：2020-12-01 00:00:00

abstract：:A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...

journal_title：Journal of immunotoxicology

authors： Kamperschroer C,O'Donnell LM,Schneider PA,Li D,Roy M,Coskran TM,Kawabata TT

更新日期：2014-01-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...

journal_title：Journal of immunotoxicology

authors： Xu L,Guo X,Li N,Pan Q,Ma YZ

更新日期：2019-12-01 00:00:00

abstract：:Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

journal_title：Journal of immunotoxicology

authors： Metushi IG,Uetrecht J

更新日期：2014-10-01 00:00:00

abstract：:Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

journal_title：Journal of immunotoxicology

authors： Terhune TD,Deth RC

更新日期：2013-04-01 00:00:00

abstract：:An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Tsutsui N,Hisada S,Vidal JM,Spanhaak S,Sawada J,Hastings KL,van der Laan JW,van Loveren H,Kawabata TT,Sims J,Durham SK,Fueki O,Matula TI,Kusunoki H,Ulrich P,Nakamura K

更新日期：2005-07-01 00:00:00