Characterization of the action of drug-induced stress responses on the immune system: evaluation of biomarkers for drug-induced stress in rats.

abstract：:Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

journal_title：Journal of immunotoxicology

authors： Peillex C,Pelletier M

更新日期：2020-12-01 00:00:00

abstract：:Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...

journal_title：Journal of immunotoxicology

authors： Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JA

更新日期：2018-12-01 00:00:00

abstract：:Among the different phenotypic changes induced by contact sensitizers in dendritic cells and myeloid cell lines, CD86 appears to be a consensus marker, since constantly described as systematically up-regulated. To evaluate the robustness of this marker, interference of cytotoxicity on CD86 expression was investigated ...

journal_title：Journal of immunotoxicology

authors： Ade N,Martinozzi-Teissier S,Pallardy M,Rousset F

更新日期：2006-12-01 00:00:00

abstract：:Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...

journal_title：Journal of immunotoxicology

authors： Dobrakowski M,Boroń M,Czuba ZP,Kasperczyk A,Machoń-Grecka A,Kasperczyk S

更新日期：2016-11-01 00:00:00

abstract：:Malignant melanoma is a very representative disease in terms of tumor progression processes. During its evolution, a series of events takes place; among these, the cells' 'out-of-control' growth and loss of homeostasis play crucial roles in the genesis of the tumor itself and its subsequent progression. These events i...

journal_title：Journal of immunotoxicology

authors： Botti G,Cerrone M,Scognamiglio G,Anniciello A,Ascierto PA,Cantile M

更新日期：2013-07-01 00:00:00

abstract：:The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

journal_title：Journal of immunotoxicology

authors： Ratanji KD,Derrick JP,Dearman RJ,Kimber I

更新日期：2014-04-01 00:00:00

abstract：:Indirubin-3-monoxime is an aryl hydrocarbon receptor (AhR)-binding, idole-derived compound known to be a potent inducer of CYP1A1, at least in hepatic cell lines. To date, very little is known about the effects of indirubin-3-monoxime on cells relevant to the immune system. We treated human U937 histiocytic lymphoma c...

journal_title：Journal of immunotoxicology

authors： Springs AE,Rice CD

更新日期：2006-01-01 00:00:00

abstract：:Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...

journal_title：Journal of immunotoxicology

authors： Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera J

更新日期：2016-05-01 00:00:00

abstract：:Previously, we showed that in utero exposure to mercury induced phenotypic changes in fetal immune cells. Here, we sought to determine whether the effects of in utero exposure on immune cells persisted in the adult. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in dr...

journal_title：Journal of immunotoxicology

authors： Pilones K,Tatum A,Gavalchin J

更新日期：2009-09-01 00:00:00

abstract：:Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

journal_title：Journal of immunotoxicology

authors： Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

更新日期：2016-01-01 00:00:00

abstract：:Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...

journal_title：Journal of immunotoxicology

authors： Fang KC

更新日期：2007-07-01 00:00:00

abstract：:The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...

journal_title：Journal of immunotoxicology

authors： Poirier M,Simard JC,Girard D

更新日期：2016-05-01 00:00:00

abstract：:The realization, that the immune system can be the target of many chemicals including environmental contaminants and drugs with potentially adverse effects on the host's health, has raised serious concerns within the public and the regulatory agencies. At present, assessment of immunotoxic effects relies on different ...

journal_title：Journal of immunotoxicology

authors： Galbiati V,Mitjans M,Corsini E

更新日期：2010-10-01 00:00:00

abstract：:Workers exposed to benzene frequently suffer from toxicities of the bone marrow as well as the central nervous, immune, and reproductive systems. This toxicity most likely is a result of the oxidative metabolism of benzene to reactive products. As green tea possesses antioxidant effects, the objective of this study wa...

journal_title：Journal of immunotoxicology

authors： Emara AM,El-Bahrawy H

更新日期：2008-01-01 00:00:00

abstract：:The objective of this study is to investigate the effects of two different yeast-derived beta-glucans on macrophage functionality and blood cholesterol levels in mice. After establishing their ability to act as a strong stimulator of macrophages, we measured the capacities of the glucans to lower blood cholesterol. Ou...

journal_title：Journal of immunotoxicology

authors： Vetvicka V,Vetvickova J

更新日期：2009-03-01 00:00:00

abstract：:Here we sought to determine whether prenatal exposure to subtoxic levels of inorganic mercury induced modulations in the fetal immune repertoire. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. DBF(1) pups were examined at day...

journal_title：Journal of immunotoxicology

authors： Pilones K,Lai ZW,Gavalchin J

更新日期：2007-10-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00

abstract：:First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

journal_title：Journal of immunotoxicology

authors： Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

更新日期：2015-04-01 00:00:00

abstract：:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

journal_title：Journal of immunotoxicology

authors： Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

更新日期：2012-10-01 00:00:00

abstract：:Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...

journal_title：Journal of immunotoxicology

authors： Quinn MJ Jr,McFarland CA,LaFiandra EM,Johnson MS

更新日期：2009-09-01 00:00:00

abstract：:In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...

journal_title：Journal of immunotoxicology

authors： Mandarapu R,Prakhya BM

更新日期：2015-01-01 00:00:00

abstract：:Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...

journal_title：Journal of immunotoxicology

authors： Antoine F,Girard D

更新日期：2015-04-01 00:00:00

abstract：:In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

journal_title：Journal of immunotoxicology

authors： Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

更新日期：2020-12-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...

journal_title：Journal of immunotoxicology

authors： Anderson SE,Franko J,Anderson KL,Munson AE,Lukomska E,Meade BJ

更新日期：2013-01-01 00:00:00

abstract：:Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...

journal_title：Journal of immunotoxicology

authors： Avila S,Muñoz-García L,Vázquez-Leyva S,Salinas-Jazmín N,Medina-Rivero E,Pavón L,Mellado-Sánchez G,Chacón-Salinas R,Estrada-Parra S,Vallejo-Castillo L,Pérez-Tapia SM

更新日期：2017-12-01 00:00:00

abstract：:Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

journal_title：Journal of immunotoxicology

authors： El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

更新日期：2016-07-01 00:00:00

abstract：:Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...

journal_title：Journal of immunotoxicology

authors： Sarlo K,Adamson GM,Hollis VL,Innis JD,Babcock LS,Kirchner DB

更新日期：2004-04-01 00:00:00

abstract：:The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid i...

journal_title：Journal of immunotoxicology

authors： Vannucci L,Stepankova R,Grobarova V,Kozakova H,Rossmann P,Klimesova K,Benson V,Sima P,Fiserova A,Tlaskalova-Hogenova H

更新日期：2009-12-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

journal_title：Journal of immunotoxicology

authors： Inada T,Ueshima H,Shingu K

更新日期：2013-07-01 00:00:00