Hydrogen peroxide enhances phagocytosis of Pseudomonas aeruginosa in hyperoxia.

abstract：:Pulmonary infections have been reported to be increased in welders. Previous animal studies have indicated that manual metal arc, stainless steel welding fume (MMA-SS) increased susceptibility to lung infections. MMA-SS is composed of a complex of metals (e.g., iron, chromium, nickel). The objective was to determine w...

journal_title：Journal of immunotoxicology

authors： Antonini JM,Roberts JR

更新日期：2007-04-01 00:00:00

abstract：:Many environmental toxins have been shown to suppress the immune system across taxa. The foreign red blood cell (RBC) challenge is an important part of a complement of tests used to assess immunocompetence in the laboratory because it can assess an individual's humoral response without impacting its health. This chall...

journal_title：Journal of immunotoxicology

authors： Quinn MJ Jr,McFarland CA,LaFiandra EM,Johnson MS

更新日期：2009-09-01 00:00:00

abstract：:An anonymous survey of pharmaceutical industry practices for immunotoxicology evaluation was conducted. This was in support of the development of the guideline on the preclinical evaluation of unintended modulation of the immune system for the International Conference on Harmonization of Technical Requirements for Reg...

journal_title：Journal of immunotoxicology

authors： Weaver JL,Tsutsui N,Hisada S,Vidal JM,Spanhaak S,Sawada J,Hastings KL,van der Laan JW,van Loveren H,Kawabata TT,Sims J,Durham SK,Fueki O,Matula TI,Kusunoki H,Ulrich P,Nakamura K

更新日期：2005-07-01 00:00:00

abstract：:The concept of immunological surveillance implies that immunogenic variants of tumor cells arising in the organism can be recognized by the immune system. Tumor progression is provided by somatic evolution of tumor cells under the pressure of the immune system. The loss of MHC Class I molecules on the surface of tumor...

journal_title：Journal of immunotoxicology

authors： Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

更新日期：2014-10-01 00:00:00

abstract：:In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...

journal_title：Journal of immunotoxicology

authors： Mandarapu R,Prakhya BM

更新日期：2015-01-01 00:00:00

abstract：:Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...

journal_title：Journal of immunotoxicology

authors： Rodriguez-Lara V,Muñiz-Rivera Cambas A,González Villalva A,Fortoul TI

更新日期：2016-07-01 00:00:00

abstract：:Workers exposed to benzene frequently suffer from toxicities of the bone marrow as well as the central nervous, immune, and reproductive systems. This toxicity most likely is a result of the oxidative metabolism of benzene to reactive products. As green tea possesses antioxidant effects, the objective of this study wa...

journal_title：Journal of immunotoxicology

authors： Emara AM,El-Bahrawy H

更新日期：2008-01-01 00:00:00

abstract：:Some organophosphate insecticides have immunomodulating capacities, but it is unknown whether different compounds within this class affect the immune system to the same extent. In this in vitro study, human immortalized T-lymphocytes or bronchial epithelial cells were treated with diazinon or chlorpyrifos in the absen...

journal_title：Journal of immunotoxicology

authors： Oostingh GJ,Wichmann G,Schmittner M,Lehmann I,Duschl A

更新日期：2009-06-01 00:00:00

abstract：:Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

journal_title：Journal of immunotoxicology

authors： Metushi IG,Uetrecht J

更新日期：2014-10-01 00:00:00

abstract：:Cardiac allografts induce host immune responses that lead to endomyocardial tissue injury and progressive graft dysfunction. Inflammatory cell infiltration and myocyte damage characterize acute cellular rejection (ACR) that presents episodically in either a subclinical or symptom-associated manner. Sampling of the end...

journal_title：Journal of immunotoxicology

authors： Fang KC

更新日期：2007-07-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...

journal_title：Journal of immunotoxicology

authors： Leung-Gurung L,Escalante Cobb P,Mourad F,Zambrano C,Muscato Z,Sanchez V,Godde K,Broussard C

更新日期：2018-12-01 00:00:00

abstract：:In recent years, progress has been made in understanding how peptides presented by MHC Class I molecules were generated, in particular which proteases are involved in this process and how intracellular pathways influence antigen presentation in professional antigen-presenting cells and various types of tumor cells. Th...

journal_title：Journal of immunotoxicology

authors： Seliger B

更新日期：2008-10-01 00:00:00

abstract：:As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...

journal_title：Journal of immunotoxicology

authors： Zhang YH,Wang J,Dong GH,Liu MM,Wang D,Zheng L,Jin YH

更新日期：2013-01-01 00:00:00

abstract：:First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

journal_title：Journal of immunotoxicology

authors： Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

更新日期：2015-04-01 00:00:00

abstract：:The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors of...

journal_title：Journal of immunotoxicology

authors： Glushkova OV,Parfenyuk SB,Khrenov MO,Novoselova TV,Lunin SM,Fesenko EE,Novoselova EG

更新日期：2013-04-01 00:00:00

abstract：:Use of enzymes in cosmetic products is novel and the safety of these products is not well understood. The safety of a prototype enzyme-containing body moisturizer lotion was tested via measures of skin compatibility and potential to induce protease-specific IgE antibody in a clinical study. Female, atopic subjects (n ...

journal_title：Journal of immunotoxicology

authors： Sarlo K,Adamson GM,Hollis VL,Innis JD,Babcock LS,Kirchner DB

更新日期：2004-04-01 00:00:00

abstract：:Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

journal_title：Journal of immunotoxicology

authors： El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

更新日期：2016-07-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...

journal_title：Journal of immunotoxicology

authors： Xu L,Guo X,Li N,Pan Q,Ma YZ

更新日期：2019-12-01 00:00:00

abstract：:Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...

journal_title：Journal of immunotoxicology

authors： Frawley RP,Smith MJ,White KL Jr,Elmore SA,Herbert R,Moore R,Staska LM,Behl M,Hooth MJ,Kissling GE,Germolec DR

更新日期：2016-09-01 00:00:00

abstract：:The intestinal environment is considered to play an important role both in colorectal tumor development and in the evolution and modulation of mucosal immunity. Studies in animals reared in germ-free (GF, without any intestinal microflora) versus conventional (CV, with regular microflora in bowel) conditions can aid i...

journal_title：Journal of immunotoxicology

authors： Vannucci L,Stepankova R,Grobarova V,Kozakova H,Rossmann P,Klimesova K,Benson V,Sima P,Fiserova A,Tlaskalova-Hogenova H

更新日期：2009-12-01 00:00:00

abstract：:Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...

journal_title：Journal of immunotoxicology

authors： Avila S,Muñoz-García L,Vázquez-Leyva S,Salinas-Jazmín N,Medina-Rivero E,Pavón L,Mellado-Sánchez G,Chacón-Salinas R,Estrada-Parra S,Vallejo-Castillo L,Pérez-Tapia SM

更新日期：2017-12-01 00:00:00

abstract：:Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

journal_title：Journal of immunotoxicology

authors： Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

更新日期：2016-01-01 00:00:00

abstract：:Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...

journal_title：Journal of immunotoxicology

authors： Brand JD,Mathews JA,Kasahara DI,Wurmbrand AP,Shore SA

更新日期：2016-05-01 00:00:00

abstract：:Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

journal_title：Journal of immunotoxicology

authors： Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

更新日期：2016-07-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...

journal_title：Journal of immunotoxicology

authors： Laule CF,Wing CR,Odean EJ,Wilcox JA,Gilbert JS,Regal JF

更新日期：2017-12-01 00:00:00

abstract：:Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

journal_title：Journal of immunotoxicology

authors： Terhune TD,Deth RC

更新日期：2013-04-01 00:00:00

abstract：:Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...

journal_title：Journal of immunotoxicology

authors： Dobrakowski M,Boroń M,Czuba ZP,Kasperczyk A,Machoń-Grecka A,Kasperczyk S

更新日期：2016-11-01 00:00:00

abstract：:Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

journal_title：Journal of immunotoxicology

authors： Inada T,Ueshima H,Shingu K

更新日期：2013-07-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00