Abstract:
:Malnutrition plays a role in the development of poor physical performance, frailty and sarcopenia. The use of nutritional supplementations for improving physical performance and muscle strength parameters in older people is unclear. We therefore aimed to summarize the effect of nutritional supplementations compared to placebo on physical performance (i.e. tests more investigating physical function, utilising aerobic capacity & muscle power) and muscle strength (i.e. tests depending on muscle power) outcomes in older people in randomized controlled trials (RCTs). A literature search in major databases was undertaken until the 01st September 2018. Eligible studies were RCTs investigating the effect of nutritional supplementations vs. placebo in older people (people having an age >60 years). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used through a random effect model. Over 4007 potentially eligible articles, 32 RCTs for a total of 4137 older participants (2097 treated and 2040 placebo) (mean age: 76.3 years; 65% females) were included. Compared to placebo, multi-nutrient supplementations significantly improved chair rise time (n = 3; SMD=-0.90; 95%CI: -1.46 to -0.33; I2 = 87%). Multi-nutrients significantly improved handgrip strength when compared to placebo (n = 6; 780 participants; SMD = 0.41; 95%CI: 0.06 to 0.76; I2 = 79%), as did nutritional supplementations including protein (n = 7; 535 participants; SMD = 0.24; 95%CI: 0.07 to 0.41; I2 = 16%).Nutritional supplementations also led to a significant improvement in chair rise time and in handgrip strength in participants affected by frailty/sarcopenia and in those affected by medical conditions. In conclusion, nutritional supplementation can improve a number of physical performance outcomes in older people, particularly when they include multi-nutrients and in people already affected by specific medical conditions, or by frailty/sarcopenia.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Veronese N,Stubbs B,Punzi L,Soysal P,Incalzi RA,Saller A,Maggi Sdoi
10.1016/j.arr.2019.02.005subject
Has Abstractpub_date
2019-05-01 00:00:00pages
48-54eissn
1568-1637issn
1872-9649pii
S1568-1637(18)30343-Xjournal_volume
51pub_type
杂志文章,meta分析abstract::Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the ne...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.01.003
更新日期:2004-07-01 00:00:00
abstract::The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progre...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/s1568-1637(01)00007-1
更新日期:2002-04-01 00:00:00
abstract::Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by oth...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.03.005
更新日期:2018-07-01 00:00:00
abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.01.001
更新日期:2018-03-01 00:00:00
abstract::A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.01.011
更新日期:2019-05-01 00:00:00
abstract::A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.02.004
更新日期:2017-07-01 00:00:00
abstract::Uncoupling proteins (UCPs), which dissipate the mitochondrial proton gradient, have the ability to decouple mitochodrial respiration from ATP production. Since mitochondrial electron transport is a major source of free radical production, it is possible that UCP activity might impact free radical production. Free radi...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.03.007
更新日期:2006-05-01 00:00:00
abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101089
更新日期:2020-08-01 00:00:00
abstract::Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is suggested to contribute to changes that increase lifespan. Moreover, low T(b) has been shown to improve health and longevity independent of CR. In this review we examine the connections between CR, T(b) and mechanisms that influence longev...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2010.10.001
更新日期:2011-01-01 00:00:00
abstract::Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.06.001
更新日期:2009-10-01 00:00:00
abstract::Wnt signaling is a highly conserved pathway that participates in multiple aspects of cellular function during development and in adults. In particular, this pathway has been implicated in cell fate determination, proliferation and cell polarity establishment. In the brain, it contributes to synapse formation, axonal r...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.06.001
更新日期:2017-08-01 00:00:00
abstract::MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101023
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory ad...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101124
更新日期:2020-09-01 00:00:00
abstract::Alzheimer's disease (AD) is characterised by extracellular amyloid deposits, neurofibrillary tangles, synaptic loss, inflammation and extensive oxidative stress. Polyphenols, which include resveratrol, epigallocatechin gallate and curcumin, have gained considerable interest for their ability to reduce these hallmarks ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.06.003
更新日期:2013-09-01 00:00:00
abstract::Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101211
更新日期:2021-01-01 00:00:00
abstract::Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.05.002
更新日期:2004-11-01 00:00:00
abstract::In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101155
更新日期:2020-11-01 00:00:00
abstract::Clinical studies on intracoronary bone marrow cell (BMCs) infusion in patients with acute myocardial infarction (AMI) revealed mixed results. Recently, meta-analysis on this topic have been conducted and found that there was marked heterogeneity between trials. The objective of this systematic review is to have a retr...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2010.05.001
更新日期:2010-10-01 00:00:00
abstract::The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell co...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2012.11.002
更新日期:2013-03-01 00:00:00
abstract::Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.06.004
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2017.08.004
更新日期:2017-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2007.07.002
更新日期:2007-10-01 00:00:00
abstract::Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subset...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2010.06.004
更新日期:2011-07-01 00:00:00
abstract::As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial functio...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.09.002
更新日期:2017-10-01 00:00:00
abstract::The endoplasmic reticulum (ER) is a multifunctional organelle which co-ordinates protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins, ER stress and up-regulation of a signaling pathway called the ER stress response or the unfold...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.03.001
更新日期:2009-07-01 00:00:00
abstract::Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight th...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.08.004
更新日期:2015-11-01 00:00:00
abstract:INTRODUCTION:Many transplant studies in elderly patients focus on survival and mortality rates. It was the aim of this review to evaluate publications dealing with individual patient performance and independence. METHODS:The literature search included all articles retrievable for the hit "transplantation in elderly re...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2011.06.003
更新日期:2012-01-01 00:00:00
abstract::Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of a...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.08.004
更新日期:2018-11-01 00:00:00
abstract::The pathogenesis of frailty and the role of inflammation is poorly understood. We examined the evidence considering the relationship between inflammation and frailty through a systematic review and meta-analysis. A systematic literature search of papers providing data on inflammatory biomarkers and frailty was carried...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2016.08.006
更新日期:2016-11-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.12.007
更新日期:2014-05-01 00:00:00