Abstract：
:Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms involved. We performed a systematic literature review with specific attention to functional dissociation between the tasks used and methodological characteristics. The literature search resulted in 39 articles in which age comparisons were made for large-scale navigation measures. Outcomes were categorized into the domains of landmark, location (egocentric and allocentric), and path knowledge (route and survey). Results indicate that clear functional dissociation exists between these navigation knowledge domains. Aging effects are found for path knowledge most convincingly, while landmark and egocentric location knowledge are frequently omitted in assessment. The participant samples reported often neglect adult, middle aged participants, while this group could be highly informative to the aging process as well. Moreover, having a clear image of age-related performance across the lifespan could be a valuable addition towards the early detection of pathological aging through navigation performance.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
van der Ham IJM,Claessen MHGdoi
10.1016/j.arr.2020.101020subject
Has Abstractpub_date
2020-03-01 00:00:00pages
101020eissn
1568-1637issn
1872-9649pii
S1568-1637(19)30138-2journal_volume
58pub_type
杂志文章abstract：INTRODUCTION:Many transplant studies in elderly patients focus on survival and mortality rates. It was the aim of this review to evaluate publications dealing with individual patient performance and independence. METHODS:The literature search included all articles retrievable for the hit "transplantation in elderly re...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.06.003
更新日期：2012-01-01 00:00:00
abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published in Ageing Research Reviews, Volume 7, Issue 1, January 2008, Pages 43-48, doi:10.1016/j.arr.2007.08.004. The duplicate article has therefore been withdrawn. ...
journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2007.08.005
更新日期：2007-09-04 00:00:00
abstract：:A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.03.001
更新日期：2018-05-01 00:00:00
abstract：:MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101023
更新日期：2020-03-01 00:00:00
abstract：:The postsynaptic density protein PSD-95 is a major element of synapses. PSD-95 is involved in aging, Alzheimer's disease (AD) and numerous psychiatric disorders. However, contradictory data about PSD-95 expression in aging and AD have been reported. Indeed in AD versus control brains PSD-95 varies according to regions...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.09.004
更新日期：2014-11-01 00:00:00
abstract：:The amyloid cascade hypothesis, which implicates the amyloid Aβ peptide as the pathological initiator of both familial and sporadic, late onset Alzheimer's disease (AD), continues to guide the majority of research. We believe that current evidence does not support the amyloid cascade hypothesis for late onset AD. Inst...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.10.001
更新日期：2014-01-01 00:00:00
abstract：:Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.06.001
更新日期：2009-10-01 00:00:00
abstract：:Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.04.001
更新日期：2019-07-01 00:00:00
abstract：:The recent pandemics of the SARS-Cov-2 has pushed physical activity (PA) and exercise at the forefront of the discussion, since PA is associated with a reduced risk of developing all the chronic diseases strongly associated with severe cases of SARS-Cov-2 and exercise is considered a complimentary therapeutics for the...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2021.101258
更新日期：2021-01-12 00:00:00
abstract：:Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2004.05.002
更新日期：2004-11-01 00:00:00
abstract：:The lysosomal network is the major intracellular proteolytic system accounting for more than 98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver and muscles. Lysosomes are the final destination of intracellular damaged structures, identified and sequestered by the processes o...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.05.001
更新日期：2009-07-01 00:00:00
abstract：:Within the last years, a rapidly growing number of polyphenolic compounds with neuroprotective effects have been described. Many efforts have been made to explore the mechanisms behind the neuroprotective action of polyphenols. However, many pathways and mechanisms considered for mediating these effects are rather gen...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.01.006
更新日期：2012-04-01 00:00:00
abstract：:Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and are increasingly used to track organisms along their life-course. This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie aging, including chronic inflammation (infl...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101156
更新日期：2020-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100966
更新日期：2019-12-01 00:00:00
abstract：:Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused o...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.03.006
更新日期：2006-05-01 00:00:00
abstract：:Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailabil...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2014.10.001
更新日期：2014-11-01 00:00:00
abstract：:A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:Senescence represents a state of indefinite growth arrest in cells that have reached the end of their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent a tumor-suppressive mechanism, the accumulation of senescent cells ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.01.003
更新日期：2012-09-01 00:00:00
abstract：:The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101201
更新日期：2020-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is characterised by extracellular amyloid deposits, neurofibrillary tangles, synaptic loss, inflammation and extensive oxidative stress. Polyphenols, which include resveratrol, epigallocatechin gallate and curcumin, have gained considerable interest for their ability to reduce these hallmarks ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.06.003
更新日期：2013-09-01 00:00:00
abstract：:The aging of the human adrenal cortex presents several problems of interest to the cell biologist, as the interplay of changes in growth, differentiation, apoptosis and cellular senescence affect the properties of the tissue over the life span. The human adrenal cortex also presents an interesting case of tumor progre...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(01)00007-1
更新日期：2002-04-01 00:00:00
abstract：:The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.07.001
更新日期：2012-01-01 00:00:00
abstract：:Clinical studies on intracoronary bone marrow cell (BMCs) infusion in patients with acute myocardial infarction (AMI) revealed mixed results. Recently, meta-analysis on this topic have been conducted and found that there was marked heterogeneity between trials. The objective of this systematic review is to have a retr...
journal_title：Ageing research reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.arr.2010.05.001
更新日期：2010-10-01 00:00:00
abstract：:Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.04.004
更新日期：2017-07-01 00:00:00
abstract：:Old age is the greatest risk factor for most neurodegenerative diseases. During recent decades there have been major advances in understanding the biology of aging, and the development of nutritional interventions that delay aging including calorie restriction (CR) and intermittent fasting (IF), and chemicals that inf...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.06.006
更新日期：2016-11-01 00:00:00
abstract：:It has been well-established that the age-related loss of muscle mass and strength, or sarcopenia, impairs skeletal muscle function and reduces functional performance at a more advanced age. Skeletal muscle satellite cells (SC), as precursors of new myonuclei, have been suggested to be involved in the development of s...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.05.003
更新日期：2009-10-01 00:00:00
abstract：:Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.05.001
更新日期：2013-09-01 00:00:00
abstract：:Persons aged 80 years and older are the fastest growing segment of the population. As more individuals live longer, we should try to understand the mechanisms involved in healthy ageing and preserving functional independence in later life. In elderly people, functional independence is directly dependent on physical fi...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.09.003
更新日期：2013-01-01 00:00:00
abstract：:Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100947
更新日期：2019-11-01 00:00:00
abstract：:White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.11.006
更新日期：2017-03-01 00:00:00
