Abstract：
:MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due to preanalytical and analytical challenges. This study integrated the data across twenty-four reports to identify steadily deregulated miRNAs that may assist in the path towards biomarker development and molecular characterization of the underlying pathology. Stringent KEGG pathway analysis of the miRNA targets revealed FoxO, Prolactin, TNF, and ErbB signaling pathways as the most significantly enriched categories while Gene Ontology analysis revealed that the protein targets are mostly associated with transcription. Chromosomal location of the consistently deregulated miRNAs revealed that over a third of them were clustered at the same location at Chr14q32 suggesting that they are co-regulated by specific transcription factors. This genomic region is inherently unstable due to expanded TGG repeats and responsible for human abnormalities. Stringent analysis of transcription factor sites surrounding the deregulated miRNAs revealed that CREB1, CEBPB and MAZ sites existed in approximately half of the miRNAs, including all of the miRNAs located at Chr14q32. Additional studies are now needed to determine the biomarker potential of the consistently deregulated miRNAs in PD and the therapeutic implications of these bioinformatics insights.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Doxakis Edoi
10.1016/j.arr.2020.101023subject
Has Abstractpub_date
2020-03-01 00:00:00pages
101023eissn
1568-1637issn
1872-9649pii
S1568-1637(19)30424-6journal_volume
58pub_type
杂志文章,评审abstract：:Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101115
更新日期：2020-09-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.100966
更新日期：2019-12-01 00:00:00
abstract：:A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.02.004
更新日期：2017-07-01 00:00:00
abstract：:Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.12.007
更新日期：2014-05-01 00:00:00
abstract：:Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2013.05.001
更新日期：2013-09-01 00:00:00
abstract：:White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.11.006
更新日期：2017-03-01 00:00:00
abstract：:Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, live...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101063
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory ad...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101124
更新日期：2020-09-01 00:00:00
abstract：:Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with sev...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2019.01.007
更新日期：2019-03-01 00:00:00
abstract：:Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101089
更新日期：2020-08-01 00:00:00
abstract：:The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2018.01.001
更新日期：2018-03-01 00:00:00
abstract：:Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overview...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2005.06.004
更新日期：2005-11-01 00:00:00
abstract：:Aging is a major cause of many degenerative diseases. The most intuitive consequence of aging is mainly manifested on the skin, resulting in cumulative changes in skin structure, function and appearance, such as increased wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation of the skin. Unlike other ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101036
更新日期：2020-05-01 00:00:00
abstract：:Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.06.001
更新日期：2009-10-01 00:00:00
abstract：:Mitochondrial dysfunction and reactive oxygen species (ROS) production are at the heart of the aging process and are thought to underpin age-related diseases. Mitochondria are not only the primary energy-generating system but also the dominant cellular source of metabolically derived ROS. Recent studies unravel the ex...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.09.006
更新日期：2010-01-01 00:00:00
abstract：:Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies. The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains. Th...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2015.12.002
更新日期：2016-03-01 00:00:00
abstract：:We have long accepted that exercise is 'good for us'; that - put more rigorously - moderate exercise is associated with not just aerobic fitness but also reduced morbidity and reduced mortality from cardiovascular disease and even malignancies. Caloric restriction (moderate hunger) and our exposure to dietary phytoche...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.05.005
更新日期：2017-08-01 00:00:00
abstract：:Functional activities of mature human neutrophils are strongly influenced by the pro-inflammatory cytokine granulocyte macrophage-colony stimulating factor (GM-CSF). Accordingly, a defective response to GM-CSF might have dramatic consequences for neutrophil functions and the host defence against infections. Such an ev...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2006.10.001
更新日期：2007-08-01 00:00:00
abstract：:Aging is the main risk factor contributing to vascular dysfunction and the progression of vascular diseases. In this review, we discuss the causes and mechanisms of vascular aging at the tissue and cellular level. We focus on Endothelial Cell (EC) and Smooth Muscle Cell (SMC) aging due to their critical role in mediat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.05.006
更新日期：2017-08-01 00:00:00
abstract：:Senescence represents a state of indefinite growth arrest in cells that have reached the end of their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent a tumor-suppressive mechanism, the accumulation of senescent cells ...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2012.01.003
更新日期：2012-09-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2011.12.004
更新日期：2012-04-01 00:00:00
abstract：:Considering the increasing number of elderly in the world's population today, developing effective treatments for age-related pathologies is one of the biggest challenges in modern medical research. Age-related neurodegeneration, in particular, significantly impacts important sensory, motor, and cognitive functions, s...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2015.10.004
更新日期：2015-11-01 00:00:00
abstract：:Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101149
更新日期：2020-11-01 00:00:00
abstract：:Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms...
journal_title：Ageing research reviews
pub_type： 杂志文章
doi：10.1016/j.arr.2020.101020
更新日期：2020-03-01 00:00:00
abstract：:The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101075
更新日期：2020-08-01 00:00:00
abstract：:The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2020.101201
更新日期：2020-12-01 00:00:00
abstract：:It has been well-established that the age-related loss of muscle mass and strength, or sarcopenia, impairs skeletal muscle function and reduces functional performance at a more advanced age. Skeletal muscle satellite cells (SC), as precursors of new myonuclei, have been suggested to be involved in the development of s...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2009.05.003
更新日期：2009-10-01 00:00:00
abstract：:Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns,...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2017.04.004
更新日期：2017-07-01 00:00:00
abstract：:A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/j.arr.2016.05.002
更新日期：2017-01-01 00:00:00
abstract：:The neurohypophyseal hormones arginine-vasopressin (AVP) and oxytocin (OT) are produced in the neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nucleus and in the much smaller cells of the suprachiasmatic (SCN) nucleus. The SON is the main source of plasma AVP. Part of the AVP and OT neurons of t...
journal_title：Ageing research reviews
pub_type： 杂志文章,评审
doi：10.1016/s1568-1637(02)00013-2
更新日期：2002-06-01 00:00:00
