The role of inflammasome in Alzheimer's disease.

Abstract:

:Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1β (IL-1β) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies.

journal_name

Ageing Res Rev

journal_title

Ageing research reviews

authors

Liu L,Chan C

doi

10.1016/j.arr.2013.12.007

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

6-15

eissn

1568-1637

issn

1872-9649

pii

S1568-1637(13)00097-4

journal_volume

15

pub_type

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