Abstract:
:Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related to biological and social vulnerability may explain the specific COVID-19 burden among older people. There is already some evidence showing large social disparities in the prevention, treatment, prognosis and/or long-term consequences of COVID-19. The remaining question is to what extent these affect older adults specifically. We provide the rationale to address this question with scientific methods and proper study designs, where the interplay between individuals' biomedical status and their social environment is the focus. Only through interdisciplinary research integrating biological, clinical and social data will we be able to provide new insights into the SARS-CoV-2 pandemic and inform actions aimed at reducing older adults' vulnerability to COVID-19 or other similar pandemics in the future.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Calderón-Larrañaga A,Dekhtyar S,Vetrano DL,Bellander T,Fratiglioni Ldoi
10.1016/j.arr.2020.101149subject
Has Abstractpub_date
2020-11-01 00:00:00pages
101149eissn
1568-1637issn
1872-9649pii
S1568-1637(20)30284-1journal_volume
63pub_type
杂志文章,评审abstract::Uncoupling proteins (UCPs), which dissipate the mitochondrial proton gradient, have the ability to decouple mitochodrial respiration from ATP production. Since mitochondrial electron transport is a major source of free radical production, it is possible that UCP activity might impact free radical production. Free radi...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.03.007
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.03.001
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abstract::Aging is a paradox of reduced immunity and chronic inflammation. Dendritic cells are central orchestrators of the immune response with a key role in the generation of immunity and maintenance of tolerance. The functions of DCs are compromised with age. There is no major effect on the numbers and phenotype of DC subset...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2010.06.004
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2013.12.007
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2006.10.001
更新日期:2007-08-01 00:00:00
abstract::Human ageing is associated with a gradual decline in the physiological functions of the body at multiple levels and it is a key risk factor for many diseases, including cancer. Ageing process is intimately related to widespread cellular senescence, characterised by an irreversible loss of proliferative capacity and al...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.03.004
更新日期:2015-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/s0047-6374(01)00368-2
更新日期:2002-02-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2014.12.008
更新日期:2015-09-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.11.006
更新日期:2017-03-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章
doi:10.1016/j.arr.2020.101144
更新日期:2020-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.10.004
更新日期:2015-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析
doi:10.1016/j.arr.2019.02.005
更新日期:2019-05-01 00:00:00
abstract::This systematic review and meta-analysis investigates the impact of cognitive training and general mental stimulation on the cognitive and everyday functioning of older adults without known cognitive impairment. We examine transfer and maintenance of intervention effects, and the impact of training in group versus ind...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2014.02.004
更新日期:2014-05-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.07.003
更新日期:2017-09-01 00:00:00
abstract::Mitochondrial dysfunction and reactive oxygen species (ROS) production are at the heart of the aging process and are thought to underpin age-related diseases. Mitochondria are not only the primary energy-generating system but also the dominant cellular source of metabolically derived ROS. Recent studies unravel the ex...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.09.006
更新日期:2010-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder involving deposition of misfolded proteins in vulnerable brain regions leading to inexorable and progressive neuronal loss and deterioration of cognitive functions. The AD brain displays features typical of chronic inflammation as defined by the presence of acti...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2011.12.004
更新日期:2012-04-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.06.001
更新日期:2017-08-01 00:00:00
abstract::Senescence represents a state of indefinite growth arrest in cells that have reached the end of their replicative life span, have become damaged, or express aberrant levels of cancer-related proteins. While senescence is widely considered to represent a tumor-suppressive mechanism, the accumulation of senescent cells ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2012.01.003
更新日期:2012-09-01 00:00:00
abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.01.001
更新日期:2018-03-01 00:00:00
abstract::Perturbed neuronal calcium homeostasis is a prominent feature in Alzheimer's disease (AD). Mitochondria accumulate calcium ions (Ca(2+)) for cellular bioenergetic metabolism and suppression of mitochondrial motility within the cell. Excessive Ca(2+) uptake into mitochondria often leads to mitochondrial membrane permea...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2010.05.003
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2017.08.004
更新日期:2017-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101115
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101155
更新日期:2020-11-01 00:00:00
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journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2007.01.001
更新日期:2007-08-01 00:00:00
abstract::To study human aging is an enormous challenge. The complexity of the aging phenotype and the near impossibility of studying aging directly in humans oblige researchers to resort to models and extrapolations. Computational approaches offer a powerful set of tools to study human aging. In one direction we have data-mini...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2003.08.006
更新日期:2004-04-01 00:00:00
abstract::Selective dopaminergic cell loss in Parkinson's disease is correlated with increased levels of cellular iron. It is still hotly debated as to whether the increase in iron is an upstream event which acts to promote neurodegeneration via formation of oxidative stress or whether iron accumulates as a by-product of the ne...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.01.003
更新日期:2004-07-01 00:00:00
abstract::A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.03.001
更新日期:2018-05-01 00:00:00
abstract::Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have provided strong evidence of abnormal spontaneous brain activity in amnestic mild cognitive impairment (aMCI). However, the conclusions have been inconsistent. A meta-analysis of whole-brain rs-fMRI studies that measured differences in th...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2016.12.001
更新日期:2017-05-01 00:00:00
abstract::The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and is having a profound and yet still unfolding health and socioeconomic impacts. SARS-CoV-2, a β-coronavirus, is a highly contagious respira...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101205
更新日期:2021-01-01 00:00:00
abstract::The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101075
更新日期:2020-08-01 00:00:00