Splicing regulatory factors, ageing and age-related disease.


:Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns, yielding enormous plasticity and adaptability to cells and increasing their ability to respond to environmental challenge. The regulation of alternative splicing is critical for numerous cellular functions in both pathological and physiological conditions, and deregulated alternative splicing is a key feature of common chronic diseases. Isoform choice is controlled by a battery of splicing regulatory proteins, which include the serine arginine rich (SRSF) proteins and the heterogeneous ribonucleoprotein (hnRNP) classes of genes. These important splicing regulators have been implicated in age-related disease, and in the ageing process itself. This review will outline the important contribution of splicing regulator proteins to ageing and age-related disease.


Ageing Res Rev


Ageing research reviews


Latorre E,Harries LW




Has Abstract


2017-07-01 00:00:00












  • Age-related impairment of GM-CSF-induced signalling in neutrophils: role of SHP-1 and SOCS proteins.

    abstract::Functional activities of mature human neutrophils are strongly influenced by the pro-inflammatory cytokine granulocyte macrophage-colony stimulating factor (GM-CSF). Accordingly, a defective response to GM-CSF might have dramatic consequences for neutrophil functions and the host defence against infections. Such an ev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Tortorella C,Simone O,Piazzolla G,Stella I,Antonaci S

    更新日期:2007-08-01 00:00:00

  • Nutrition and other lifestyle influences on arterial aging.

    abstract::As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial functio...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: LaRocca TJ,Martens CR,Seals DR

    更新日期:2017-10-01 00:00:00

  • MicroRNAs linking inflamm-aging, cellular senescence and cancer.

    abstract::Epidemiological and experimental data demonstrate a strong correlation between age-related chronic inflammation (inflamm-aging) and cancer development. However, a comprehensive approach is needed to clarify the underlying molecular mechanisms. Chronic inflammation has mainly been attributed to continuous immune cells ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Olivieri F,Rippo MR,Monsurrò V,Salvioli S,Capri M,Procopio AD,Franceschi C

    更新日期:2013-09-01 00:00:00

  • ER and aging-Protein folding and the ER stress response.

    abstract::The endoplasmic reticulum (ER) is a multifunctional organelle which co-ordinates protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins, ER stress and up-regulation of a signaling pathway called the ER stress response or the unfold...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Naidoo N

    更新日期:2009-07-01 00:00:00

  • Do not neglect the role of circadian rhythm in muscle atrophy.

    abstract::In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Zhang H,Liang J,Chen N

    更新日期:2020-11-01 00:00:00

  • Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

    abstract::The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Guan SP,Seet RCS,Kennedy BK

    更新日期:2020-12-01 00:00:00

  • Age-related changes in total and regional fat distribution.

    abstract::Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Kuk JL,Saunders TJ,Davidson LE,Ross R

    更新日期:2009-10-01 00:00:00

  • Lipotoxicity, overnutrition and energy metabolism in aging.

    abstract::The safest place to store lipids is the white adipose tissue, but its storage capacity may become saturated resulting in excess of fat "overspilled" to non-adipose tissues. This overspill of fat occurs in apparently opposite pathological states such as lipodistrophy or obesity. When the excess of energy is redirected ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Slawik M,Vidal-Puig AJ

    更新日期:2006-05-01 00:00:00

  • Effects of physical exercise therapy on mobility, physical functioning, physical activity and quality of life in community-dwelling older adults with impaired mobility, physical disability and/or multi-morbidity: a meta-analysis.

    abstract::This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: de Vries NM,van Ravensberg CD,Hobbelen JS,Olde Rikkert MG,Staal JB,Nijhuis-van der Sanden MW

    更新日期:2012-01-01 00:00:00

  • Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age.

    abstract::The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 diffe...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析


    authors: Johnson AA,Shokhirev MN,Wyss-Coray T,Lehallier B

    更新日期:2020-07-01 00:00:00

  • Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research.

    abstract::The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Agbangla NF,Audiffren M,Albinet CT

    更新日期:2017-09-01 00:00:00

  • Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.

    abstract::Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monopho...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Shah SZA,Zhao D,Hussain T,Yang L

    更新日期:2017-11-01 00:00:00

  • Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline.

    abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Navakkode S,Liu C,Soong TW

    更新日期:2018-03-01 00:00:00

  • The role of vascular stem cells in atherogenesis and post-angioplasty restenosis.

    abstract::It is well known that atherosclerosis prevails in elderly populations as ageing acts as a recognized risk factor for this disease. Although the pathogenic factors leading to atherosclerosis are highly heterogeneous, traditionally speaking, the causative risk factors include hyperlipidemia, hypertension, diabetes melli...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Qian H,Yang Y,Li J,Huang J,Dou K,Yang G

    更新日期:2007-08-01 00:00:00

  • Ageing and neurodegenerative diseases.

    abstract::Ageing, which all creatures must encounter, is a challenge to every living organism. In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of ageing appear, c...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Hung CW,Chen YC,Hsieh WL,Chiou SH,Kao CL

    更新日期:2010-11-01 00:00:00

  • Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

    abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Heiskanen V,Pfiffner M,Partonen T

    更新日期:2020-08-01 00:00:00

  • Ischemic preconditioning in the aging heart: from bench to bedside.

    abstract::Coronary artery disease is the leading cause of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. Cardiac ischemic preconditioning represents the most powerf...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Abete P,Cacciatore F,Testa G,Della-Morte D,Galizia G,de Santis D,Calabrese C,Cioppa A,Ferrara N,Rengo F

    更新日期:2010-04-01 00:00:00

  • Solid organ transplantation: technical progress meets human dignity: a review of the literature considering elderly patients' health related quality of life following transplantation.

    abstract:INTRODUCTION:Many transplant studies in elderly patients focus on survival and mortality rates. It was the aim of this review to evaluate publications dealing with individual patient performance and independence. METHODS:The literature search included all articles retrievable for the hit "transplantation in elderly re...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Kniepeiss D,Wagner D,Pienaar S,Thaler HW,Porubsky C,Tscheliessnigg KH,Roller RE

    更新日期:2012-01-01 00:00:00

  • Exercise and skeletal muscle ageing: cellular and molecular mechanisms.

    abstract::As we age, our skeletal muscle becomes smaller and weaker. In addition, the remaining muscle is more susceptible to damage, particularly following exercise, recovery from damage is severely impaired and muscle is unable to adapt rapidly following sequential periods of exercise. The mechanisms by which skeletal muscle ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: McArdle A,Vasilaki A,Jackson M

    更新日期:2002-02-01 00:00:00

  • Discovering causes and cures for cancer from gene expression analysis.

    abstract::Tumorigenesis is governed by a series of complex genetic and epigenetic changes. Both mechanisms can result in either the silencing or aberrant expression of messages in a cell. Gene expression profiling techniques such as the serial analysis of gene expression (SAGE) or microarray analysis can provide global overview...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Weeraratna AT

    更新日期:2005-11-01 00:00:00

  • Compromised respiratory adaptation and thermoregulation in aging and age-related diseases.

    abstract::Mitochondrial dysfunction and reactive oxygen species (ROS) production are at the heart of the aging process and are thought to underpin age-related diseases. Mitochondria are not only the primary energy-generating system but also the dominant cellular source of metabolically derived ROS. Recent studies unravel the ex...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Chan SL,Wei Z,Chigurupati S,Tu W

    更新日期:2010-01-01 00:00:00

  • Molecular mechanisms of age-related hearing loss.

    abstract::Age-related hearing loss, known as presbyacusis, is characterized by the progressive deterioration of auditory sensitivity associated with aging and is the most common cause of adult auditory deficiency in the United States. Presbyacusis is defined as a progressive, bilateral, high-frequency hearing loss that is manif...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Seidman MD,Ahmad N,Bai U

    更新日期:2002-06-01 00:00:00

  • Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.

    abstract::Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Swords GM,Nguyen LT,Mudar RA,Llano DA

    更新日期:2018-07-01 00:00:00

  • Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity.

    abstract::A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Cespón J,Miniussi C,Pellicciari MC

    更新日期:2018-05-01 00:00:00

  • The eye as a model of ageing in translational research--molecular, epigenetic and clinical aspects.

    abstract::The eye and visual system are valuable in many areas of translational research such as stem cell therapy, transplantation research and gene therapy. Changes in many ocular tissues can be measured directly, easily and objectively in vivo (e.g. lens transparency; retinal blood vessel calibre; corneal endothelial cell co...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Pathai S,Shiels PG,Lawn SD,Cook C,Gilbert C

    更新日期:2013-03-01 00:00:00

  • Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease.

    abstract::Perturbed neuronal calcium homeostasis is a prominent feature in Alzheimer's disease (AD). Mitochondria accumulate calcium ions (Ca(2+)) for cellular bioenergetic metabolism and suppression of mitochondrial motility within the cell. Excessive Ca(2+) uptake into mitochondria often leads to mitochondrial membrane permea...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Hung CH,Ho YS,Chang RC

    更新日期:2010-10-01 00:00:00

  • Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

    abstract::A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA d...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Shiloh Y,Lederman HM

    更新日期:2017-01-01 00:00:00

  • How age relates to spatial navigation performance: Functional and methodological considerations.

    abstract::Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms...

    journal_title:Ageing research reviews

    pub_type: 杂志文章


    authors: van der Ham IJM,Claessen MHG

    更新日期:2020-03-01 00:00:00

  • Caloric restriction and longevity: effects of reduced body temperature.

    abstract::Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is suggested to contribute to changes that increase lifespan. Moreover, low T(b) has been shown to improve health and longevity independent of CR. In this review we examine the connections between CR, T(b) and mechanisms that influence longev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审


    authors: Carrillo AE,Flouris AD

    更新日期:2011-01-01 00:00:00

  • Added value of elder abuse definitions: a review.

    abstract::Elder abuse has devastating consequences for older persons such as a poor quality of life, psychological distress, and loss of property and security. It is also associated with increased mortality and morbidity. Elder abuse is a problem that manifests itself in both rich and poor countries and at all levels of society...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mysyuk Y,Westendorp RG,Lindenberg J

    更新日期:2013-01-01 00:00:00