Abstract:
:Alpha-synuclein aggregation is associated with Parkinson's disease and other neurodegenerative disorders termed synucleinopathies. The sequence of alpha-synuclein has a remarkable amount of lysines, which may be a target for modifications by several aldehydes found at increased concentration in parkinsonian brains. The involved aldehydes are the dopamine metabolite 3,4-dihydroxyphenylacetaldehyde, the lipid peroxidation products 4-hydroxynonenal, acrolein and malondialdehyde, and advanced glycation end-products. Moreover, both relative expression levels and enzymatic activity of aldehyde dehydrogenases, which are responsible for aldehydes detoxification in cells, are altered in Parkinson's disease brains. The effects of aldehyde modifications can include: (i) a perturbation in the equilibrium of cytosolic and membrane-bound alpha-synuclein, that may alter protein function and lead to aggregation; (ii) the reduction of alpha-synuclein ubiquitination and SUMOylation, affecting its cellular localization and clearance; (iii) a decreased susceptibility to cleavage at specific sites by extracellular proteases; (iv) a reduced availability of identified lysine acetylation sites; (v) the production of toxic oligomeric alpha-synuclein-aldehyde species, able to damage lipid membranes and transmissible from unhealthy to healthy neurons. All of these observations point to a complex interaction between alpha-synuclein and aldehydes in brain, which may lead to the accumulation of dysfunctional alpha-synuclein and its oligomerization.
journal_name
Ageing Res Revjournal_title
Ageing research reviewsauthors
Plotegher N,Bubacco Ldoi
10.1016/j.arr.2015.12.002subject
Has Abstractpub_date
2016-03-01 00:00:00pages
62-71eissn
1568-1637issn
1872-9649pii
S1568-1637(15)30037-4journal_volume
26pub_type
杂志文章,评审abstract::Aging is associated with a general decline in physiological functions including cognitive functions. Given that the hippocampus is known to be critical for certain forms of learning and memory, it is not surprising that a number of neuronal processes in this brain area appear to be particularly vulnerable to the aging...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2004.05.002
更新日期:2004-11-01 00:00:00
abstract::The neurohypophyseal hormones arginine-vasopressin (AVP) and oxytocin (OT) are produced in the neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nucleus and in the much smaller cells of the suprachiasmatic (SCN) nucleus. The SON is the main source of plasma AVP. Part of the AVP and OT neurons of t...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/s1568-1637(02)00013-2
更新日期:2002-06-01 00:00:00
abstract::The use of non-human primate models is required to understand the ageing process and evaluate new therapies against age-associated pathologies. The present article summarizes all the contributions of the grey mouse lemur Microcebus murinus, a small nocturnal prosimian primate, to the understanding of the mechanisms of...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2011.07.001
更新日期:2012-01-01 00:00:00
abstract::Ageing is manifested as functional and structural deterioration that affects cell and tissue physiology. mRNA translation is a central cellular process, supplying cells with newly synthesized proteins. Accumulating evidence suggests that alterations in protein synthesis are not merely a corollary but rather a critical...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2014.12.008
更新日期:2015-09-01 00:00:00
abstract::As the skeleton ages, the balanced formation and resorption of normal bone remodeling is lost, and bone loss predominates. The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and cytoske...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.09.005
更新日期:2011-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.100966
更新日期:2019-12-01 00:00:00
abstract::Autophagy, a major catabolic pathway responsible of the elimination of damaged proteins and organelles, is now recognized as an anti-aging process. In addition to its basal role in cell homeostasis, autophagy is also a stress-responsive mechanism for survival purposes. Here, we review recent literature to highlight th...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.08.004
更新日期:2015-11-01 00:00:00
abstract::Within the last years, a rapidly growing number of polyphenolic compounds with neuroprotective effects have been described. Many efforts have been made to explore the mechanisms behind the neuroprotective action of polyphenols. However, many pathways and mechanisms considered for mediating these effects are rather gen...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2012.01.006
更新日期:2012-04-01 00:00:00
abstract::Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Such minimally-invasive samplin...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101091
更新日期:2020-09-01 00:00:00
abstract::Aging is a major cause of many degenerative diseases. The most intuitive consequence of aging is mainly manifested on the skin, resulting in cumulative changes in skin structure, function and appearance, such as increased wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation of the skin. Unlike other ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101036
更新日期:2020-05-01 00:00:00
abstract::A wide array of cell signaling mediators and their interactions play vital roles in neuroinflammation associated with ischemia, brain trauma, developmental disorders and age-related neurodegeneration. Along with neurons, microglia and astrocytes are also affected by the inflammatory cascade by releasing pro-inflammato...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.02.004
更新日期:2017-07-01 00:00:00
abstract::Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.04.001
更新日期:2019-07-01 00:00:00
abstract::A literature search was carried out to review the influence of 'ageing' on pharmacotherapeutic decision-making, specifically how 'age' is defined and considered in the utilisation of medication. Embase, Medline, International Pharmaceutical Abstracts, and Google scholar were canvassed in a three-tiered search accordin...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.07.006
更新日期:2015-11-01 00:00:00
abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101089
更新日期:2020-08-01 00:00:00
abstract::Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression. Interestingly, an enhancement of glucose uptake, glycolysis and pentose phosphate pathway occurs in both cancer cells and am...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.100915
更新日期:2019-08-01 00:00:00
abstract::Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have provided strong evidence of abnormal spontaneous brain activity in amnestic mild cognitive impairment (aMCI). However, the conclusions have been inconsistent. A meta-analysis of whole-brain rs-fMRI studies that measured differences in th...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2016.12.001
更新日期:2017-05-01 00:00:00
abstract::The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101075
更新日期:2020-08-01 00:00:00
abstract::This is the first meta-analysis focusing on elderly patients with mobility problems, physical disability and/or multi-morbidity. The aim of this study is to assess the effect of physical exercise therapy on mobility, physical functioning, physical activity and quality of life. A broad systematic literature search was ...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2011.11.002
更新日期:2012-01-01 00:00:00
abstract::Aging is the main risk factor contributing to vascular dysfunction and the progression of vascular diseases. In this review, we discuss the causes and mechanisms of vascular aging at the tissue and cellular level. We focus on Endothelial Cell (EC) and Smooth Muscle Cell (SMC) aging due to their critical role in mediat...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.05.006
更新日期:2017-08-01 00:00:00
abstract::Wnt signaling is a highly conserved pathway that participates in multiple aspects of cellular function during development and in adults. In particular, this pathway has been implicated in cell fate determination, proliferation and cell polarity establishment. In the brain, it contributes to synapse formation, axonal r...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.06.001
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...
journal_title:Ageing research reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.arr.2017.08.004
更新日期:2017-11-01 00:00:00
abstract::Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with sev...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2019.01.007
更新日期:2019-03-01 00:00:00
abstract::Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.06.004
更新日期:2018-11-01 00:00:00
abstract::Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, live...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2020.101063
更新日期:2020-07-01 00:00:00
abstract::Alternative splicing is a co-transcriptional process, which allows for the production of multiple transcripts from a single gene and is emerging as an important control point for gene expression. Alternatively expressed isoforms often have antagonistic function and differential temporal or spatial expression patterns,...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2017.04.004
更新日期:2017-07-01 00:00:00
abstract::The role of epigenetics in aging and age-related diseases is a key issue in molecular physiology and medicine because certain epigenetic factors are thought to mediate, at least in part, the relationship between the genome and the environment. An active role for epigenetics in aging must meet two prior conditions: the...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.03.004
更新日期:2009-10-01 00:00:00
abstract::Aging is associated with progressive changes in total and regional fat distribution that have negative health consequences. Indeed, a preferential increase in abdominal fat, in particular visceral fat, combined with a decrease in lower body subcutaneous fat are commonly cited in the literature. These age-related chang...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2009.06.001
更新日期:2009-10-01 00:00:00
abstract::A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2018.03.001
更新日期:2018-05-01 00:00:00
abstract::Human ageing is associated with a gradual decline in the physiological functions of the body at multiple levels and it is a key risk factor for many diseases, including cancer. Ageing process is intimately related to widespread cellular senescence, characterised by an irreversible loss of proliferative capacity and al...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2015.03.004
更新日期:2015-09-01 00:00:00
abstract::As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. ...
journal_title:Ageing research reviews
pub_type: 杂志文章,评审
doi:10.1016/j.arr.2016.09.007
更新日期:2017-03-01 00:00:00